(1)分子病毒学，病毒感染与代谢重塑。

(2)代谢重编程调控肝癌发生发展的分子机制研究。

Viruses hijack host cell metabolism for their survival and reproduction. Our group focus on host–pathogen interactions at the metabolic level. We are interested in how viruses alter the metabolism of host cells, and how these changes can be exploited to develop antiviral strategies.

The metabolic reprogramming induced by oncovirus is critical for the malignant transformation. We are using metabolomic,CRISPR and proteomic approaches to study key metabolic pathways that support hepatitis B virus (HBV) replication, and how viral-induced metabolic reprogramming contributes to oncogenesis. We aim to explore novel diagnosis and therapy strategies for virus-related cancers (HBV-related hepatocellular carcinoma). 

We are also intreasted in the crosstalk between cell metabolism and signaling pathways, as well as identification of new therapeutic targets for HCC treatment. 

My ORCID:  https://orcid.org/0000-0002-0137-1247