1. Zhongqi Feng^#, Jiaxin Yin^#, Zhirong Zhang^#, Zhen Chen, Luyi Huang*, Ni Tang*, Kai Wang*, O-GlcNAcylation of E3 ubiquitin ligase SKP2 promotes hepatocellular carcinoma proliferation. Oncogene, 2024. 
   

2. Dan Nie^#, Xin Tang^#, Haijun Deng^#, Xiaojun Yang^#, Junji Tao, Fengli Xu, Yi Liu, Kang Wu, Kai Wang*, Zhechuan Mei*, Ailong Huang*, Ni Tang*, Metabolic enzyme SLC27A5 regulates PIP4K2A pre-mRNA splicing as a noncanonical mechanism to suppress hepatocellular carcinoma metastasis. Advanced Science, 2024. 

3. Rui Liu^#, Yi Liu^#, Wenlu Zhang^#, Guiji Zhang^#, Zhirong Zhang, Luyi Huang, Ni Tang*, Kai Wang*, PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma. Genes & Diseases, 2024. 

4. De-ao Gong^#, Peng Zhou^#, Wen-yi Chang^#, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang*, Kai Wang*, SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer. Biochimica et Biophysica Acta - Molecular Cell Research. 2024. 

5. Peng Zhou^#, Wen-yi Chang^#, De-ao Gong^#, Jie Xia^#, Wei Chen, Lu-yi Huang, Rui Liu, Yi Liu, Chang Chen, Kai Wang*, Ni Tang*, Ai-long Huang*, High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate. Cell Metabolism, 2023. (*Co-corresponding author) 

6. Dongmei Gou^#, Rui Liu^#, Xiaoqun Shan^#, Haijun Deng^#, Chang Chen^#, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang*, Kai Wang*, Ni Tang*, Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression. Journal of Clinical Investigation, 2023.

7. Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang*, Ailong Huang*, Ni Tang*, Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice. Nature Communications, 2023.

8. Yang Yang^#, Yu Yan^#, Jiaxin Yin^#, Ni Tang^#, Kai Wang^#, Luyi Huang, Jie Hu, Zhongqi Feng, Qingzhu Gao, Ailong Huang*, O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner. Signal Transduction and Targeted Therapy, 2023.  (#Co-first author)

9. Jin Xiang#, Kai Wang*, Ni Tang*, PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities. Genes & Diseases, 2023.

10. Peng Zhou^#, Wen-yi Chang^#, De-ao Gong^#, Lu-yi Huang, Rui Liu, Yi Liu, Jie Xia, Kai Wang*, Ni Tang*, Ai-long Huang*, O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma. Oncogene, 2023.  

11. Huating Luo^#, Qiujie Wang^#, Fan Yang^#, Rui Liu^#, Qingzhu Gao^#, Bin Cheng, Xue Lin, Luyi Huang, Chang Chen, Jin Xiang, Kai Wang*, Bo Qin*, Ni Tang*, Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma. JCI Insight. 2023. 

12. Qingzhu Gao^#, Bin Cheng^#, Chang Chen^#, Chong Lei^#, Xue Lin, Dan Nie, Jingjing Li, Luyi Huang, Xiaosong Li, Kai Wang*, Ailong Huang*, Ni Tang*, Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signaling pathway. Clinical and Translational Medicine, 2022. 

13. Jie Hu#, Xiao-yu Wei#, Jin Xiang#, Pai Peng, Feng-li Xu, Kang Wu, Fei-yang Luo, Ai-shun Jin, Liang Fang, Bei-zhong Liu*, Kai Wang*, Ni Tang*, Ai-Long Huang*, Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera. Genes & Diseases, 2022. 
    

14. Binli Mao^#, Vu Thuy Khanh Le-Trilling^#, Kai Wang^#, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang*, Ni Tang*, Mirko Trilling*, Yong Lin*，Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro. Emerging Microbes & Infections, 2022. (^#Co-first author)

15. Jin Xiang^#, Chang Chen^#, Rui Liu^#, Dongmei Gou^#, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang*, Kai Wang*, Ni Tang*, Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation. Journal of Clinical Investigation, 2021. 

16. Rui Liu^#, Dongmei Gou^#, Jin Xiang^#, Xuanming Pan, Qingzhu Gao, Peng Zhou, Yi Liu, Jie Hu, Kai Wang*, Ni Tang*, O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis. Oncogene, 2021. 

17. Pai Peng^#, Hai-jun Deng^#, Jie Hu^#, Xiao-yu Wei, Jian-jiang Xue, Ting-ting Li, Liang Fang, Bei-zhong Liu, Ai-shun Jin, Feng-li Xu, Kang Wu, Quan-xin Long, Juan Chen, Kai Wang*, Ni Tang*, Ai-long Huang*, Humoral responses in naive or SARS-CoV-2 experienced individuals vaccinated with an inactivated vaccine. Cell Discovery, 2021.

18. Kai Wang#, Quan-Xin Long#, Hai-Jun Deng#, Jie Hu#, Qing-Zhu Gao, Gui-Ji Zhang, Chang-long He, Lu-Yi Huang, Jie-li Hu, Juan Chen*, Ni Tang*, Ai-Long Huang*, Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Clinical Infectious Diseases, 2021. 

19. Qiujie Wang^#, Bin Cheng^#, Qiang Xue^#, Qingzhu Gao, Ailong Huang*, Kai Wang*, Ni Tang*, GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death & Disease, 2021.
    

20. Yi Liu^#, Haijun Deng^#, Li Liang, Guiji Zhang, Jie Xia, Keyue Ding, Ni Tang*, Kai Wang*, Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway. Genes & Diseases, 2021. 

21. Chang-Long He^#, Lu-Yi Huang^#, Kai Wang^#, Chen-Jian Gu, Jie Hu, Gui-Ji Zhang, Wei Xu, You-Hua Xie*, Ni Tang*, Ai-Long Huang*, Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. Signal Transduction and Targeted Therapy, 2021. (^#Co-first author)

22. Jie Hu^# , Pai Peng^#, Kai Wang^#, Liang Fang, Fei-yang Luo, Ai-shun Jin, Bei-zhong Liu*, Ni Tang*, Ai-long Huang*, Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies. Cellular & Molecular Immunology, 2021.

23. Pai Peng^#, Jie Hu^#, Hai-jun Deng, Bei-zhong Liu, Liang Fang, Kai Wang*, Ni Tang*, Ai-long Huang*, Changes of humoral immunity response in SARS-CoV-2 convalescent patients over 8 months. Cellular & Molecular Immunology, 2021. 

24. Jie Hu^#, Qingzhu Gao^#, Changlong He, Ailong Huang, Ni Tang*, Kai Wang*, Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2. Genes & Diseases, 2020. 

25. Jie Hu^#, Qingzhu Gao^#, Yang Yang^#, Jie Xia^#, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang*, Ailong Huang*, Ni Tang*, Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation. Theranostics, 2021.

26. Qingzhu Gao^#, Guiji Zhang^#, Yaqiu Zheng^#, Yi Yang^#, Chang Chen, Jie Xia, Li Liang, Chong Lei, Yuan Hu, Xue-Fei Cai, Wenlu Zhang, Hua Tang, Yaxi Chen, Ailong Huang*, Kai Wang*, Ni Tang*, SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC. Cell Death & Differentiation, 2020. 

27. Guiji Zhang^#, Xia Tang^#, Li Liang^#, Wanfeng Zhang, Dewei Li, Xiaoyuan Li, Dachun Zhao, Yaqiu Zheng, Yanhong Chen, Bingtao Hao, Kai Wang*, Ni Tang*, Keyue Ding*, DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma, Oncogene, 2020. 

28. Jin Xiang^#, Yuhong Zhang^#, Lin Tuo, Rui Liu, Dongmei Gou, Li Liang, Chang Chen, Jie Xia, Ni Tang, Kai Wang*, Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-Seq. Genes & Diseases, 2020. 

29. Chong Lei^#, Qiujie Wang, Ni Tang*, Kai Wang*, GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells. FEBS Open Bio, 2020.

30. Jingjing Li^#, Qiujie Wang^#, Yi Yang, Chong Lei, Fan Yang, Li Liang, Chang Chen, Jie Xia, Kai Wang*, Ni Tang*, GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Journal of Experimental & Clinical Cancer Research, 2019.

31. Fan Yang^#, Jingjing Li^#, Haijun Deng^#, Yihao Wang, Chong Lei, Qiujie Wang, Jin Xiang, Li Liang, Jie Xia, Xuanming Pan, Xiaosong Li, Quanxin Long, Lei Chang, Ping Xu, Ailong Huang*, Kai Wang*, Ni Tang*, GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. The EMBO Journal, 2019. 

32. Xuemei Chen^#, Yuan Hu^#, Wenlu Zhang, Ke Chen, Jie Hu, Xiaosong Li, Li Liang, Xuefei Cai, Jieli Hu, Kai Wang*, Ailong Huang*, Ni Tang*, Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radical Biology and Medicine, 2019. 

33. Lin Tuo^#, Jin Xiang^#, Xuanming Pan^#, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang*, Kai Wang*, Ni Tang*, PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27^Kip1 axis. Journal of Experimental & Clinical Cancer Research, 2019.

34. Qingzhu Gao^#, Kai Wang^#, Ke Chen, Li Liang, Yaqiu Zheng, Yunzhi Zhang, Jin Xiang, Ni Tang *, HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma. Cancer Science, 2017. 

35. Kai Wang^#, Wei Lv^#, Jianfei Chen^#, Shiqi Xie, Hongyan Shi, Haojen Hsu, Wenjing Yu, Ke Xu, Chao Bian, Wolfgang B Fischer, Wolfgang Schwarz, Li Feng*, Bing Sun*, PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS Letters, 2012.

36. Kai Wang^#, Shiqi Xie, Bing Sun*. Viral proteins function as ion channels. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2011.

37. Shiqi Xie^#, Kai Wang^#, Wenjing Yu, Wei Lv, Ke Xu, Jianwei Wang, Bin Ye, Wolfgang Schwarz, Qi Jin*, Bing Sun*, DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71, Cell Research, 2011. (^#Co-first author)

38. Ronghua Zhang^#, Kai Wang^#, Wei Lv^#, Wenjing Yu, Shiqi Xie, Ke Xu, Wolfgang Schwarz, Sidong Xiong*, Bing Sun*, The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014. 

39. Ronghua Zhang^#, Kai Wang, Xianqiang Ping, Wenjing Yu, Zhikang Qian, Sidong Xiong*, Bing Sun*, The ns12. 9 accessory protein of human coronavirus OC43 is a viroporin involved in virion morphogenesis and pathogenesis. Journal of Virology, 2015.

40. Silvia Schwarz^#, Kai Wang, Wenjing Yu, Bing Sun, Wolfgang Schwarz*, Emodin inhibits current through SARS-associated coronavirus 3a protein. Antiviral Research, 2011.

41. Silvia Schwarz^#, Daniel Sauter, Kai Wang, Ronghua Zhang, Bing Sun, Anastasia Karioti, Anna Rita Bilia, Thomas Efferth, Wolfgang Schwarz*, Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta medica, 2014.

42. Daniel Sauter^#, Silvia Schwarz, Kai Wang, Ronghua Zhang, Bing Sun, Wolfgang Schwarz*, Genistein as antiviral drug against HIV ion channel. Planta medica, 2014.

43. 潘璇明，张桂冀，陈雪梅，梁利，唐霓，汪凯^*. 果糖-1，6-二磷酸酶1抑制肝癌细胞株HepG2的自噬及增殖. 中华肝脏病杂志, 2019.

44. 向进，庹琳，高庆祝，杨翼，梁利，夏杰，唐霓，汪凯^*. PCK1影响肝癌细胞迁移能力的研究. 重庆医科大学学报, 2018.

45. 龚德敖，唐霓，汪凯^*. 斑点型锌指结构蛋白在肿瘤中的作用. 生命的化学，2022.

46. 杨佳瑶，唐霓，汪凯^*. 己糖胺生物合成途径代谢酶与OGT介导的O-GlcNAc修饰在肿瘤中的研究进展. 重庆医科大学学报，2023.

# These authors contributed equally.  *Co-corresponding author.