Dan Nie^#, Xin Tang^#, Haijun Deng^#, Xiaojun Yang^#, Junji Tao, Fengli Xu, Yi Liu, Kang Wu, Kai Wang*, Zhechuan Mei*, Ailong Huang*, Ni Tang*, Metabolic enzyme SLC27A5 regulates PIP4K2A pre-mRNA splicing as a noncanonical mechanism to suppress hepatocellular carcinoma metastasis. Advanced Science, 2024. (*Co-corresponding author) 

Rui Liu^#, Yi Liu^#, Wenlu Zhang^#, Guiji Zhang^#, Zhirong Zhang, Luyi Huang, Ni Tang*, Kai Wang*, PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma. Genes & Diseases, 2024. 

De-ao Gong^#, Peng Zhou^#, Wen-yi Chang^#, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang*, Kai Wang*, SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer. Biochimica et Biophysica Acta - Molecular Cell Research. 2024. 

Peng Zhou^#, Wen-yi Chang^#, De-ao Gong^#, Jie Xia^#, Wei Chen, Lu-yi Huang, Rui Liu, Yi Liu, Chang Chen, Kai Wang*, Ni Tang*, Ai-long Huang*, High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate. Cell Metabolism, 2023. (*Co-corresponding author) 

Dongmei Gou^#, Rui Liu^#, Xiaoqun Shan^#, Haijun Deng^#, Chang Chen^#, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang*, Kai Wang*, Ni Tang*, Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression. Journal of Clinical Investigation, 2023. (*Co-corresponding author) 

Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang*, Ailong Huang*, Ni Tang*, Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice. Nature Communications, 2023. (*Co-corresponding author)

Yang Yang^#, Yu Yan^#, Jiaxin Yin^#, Ni Tang^#, Kai Wang^#, Luyi Huang, Jie Hu, Zhongqi Feng, Qingzhu Gao, Ailong Huang*, O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner. Signal Transduction and Targeted Therapy, 2023.  (#Co-first author)

Jin Xiang#, Kai Wang*, Ni Tang*, PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities. Genes & Diseases, 2023.

Peng Zhou^#, Wen-yi Chang^#, De-ao Gong^#, Lu-yi Huang, Rui Liu, Yi Liu, Jie Xia, Kai Wang*, Ni Tang*, Ai-long Huang*, O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma. Oncogene, 2023.  

Huating Luo^#, Qiujie Wang^#, Fan Yang^#, Rui Liu^#, Qingzhu Gao^#, Bin Cheng, Xue Lin, Luyi Huang, Chang Chen, Jin Xiang, Kai Wang*, Bo Qin*, Ni Tang*, Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma. JCI Insight. 2023. 

Qingzhu Gao^#, Bin Cheng^#, Chang Chen^#, Chong Lei^#, Xue Lin, Dan Nie, Jingjing Li, Luyi Huang, Xiaosong Li, Kai Wang*, Ailong Huang*, Ni Tang*, Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signaling pathway. Clinical and Translational Medicine, 2022. (*Co-corresponding author)

Jie Hu#, Xiao-yu Wei#, Jin Xiang#, Pai Peng, Feng-li Xu, Kang Wu, Fei-yang Luo, Ai-shun Jin, Liang Fang, Bei-zhong Liu*, Kai Wang*, Ni Tang*, Ai-Long Huang*, Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera. Genes & Diseases, 2022. (*Co-corresponding author) 

Binli Mao^#, Vu Thuy Khanh Le-Trilling^#, Kai Wang^#, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang*, Ni Tang*, Mirko Trilling*, Yong Lin*，Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro. Emerging Microbes & Infections, 2022. (^#Co-first author)

Jin Xiang^#, Chang Chen^#, Rui Liu^#, Dongmei Gou^#, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang*, Kai Wang*, Ni Tang*, Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation. Journal of Clinical Investigation, 2021. (*Co-corresponding author) 

Rui Liu^#, Dongmei Gou^#, Jin Xiang^#, Xuanming Pan, Qingzhu Gao, Peng Zhou, Yi Liu, Jie Hu, Kai Wang*, Ni Tang*, O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis. Oncogene, 2021, doi: 10.1038/s41388-021-02058-z  (*Co-corresponding author) 

Pai Peng^#, Hai-jun Deng^#, Jie Hu^#, Xiao-yu Wei, Jian-jiang Xue, Ting-ting Li, Liang Fang, Bei-zhong Liu, Ai-shun Jin, Feng-li Xu, Kang Wu, Quan-xin Long, Juan Chen, Kai Wang*, Ni Tang*, Ai-long Huang*, Humoral responses in naive or SARS-CoV-2 experienced individuals vaccinated with an inactivated vaccine. Cell Discovery, 2021. (*Co-corresponding author) 

Kai Wang#, Quan-Xin Long#, Hai-Jun Deng#, Jie Hu#, Qing-Zhu Gao, Gui-Ji Zhang, Chang-long He, Lu-Yi Huang, Jie-li Hu, Juan Chen*, Ni Tang*, Ai-Long Huang*, Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Clinical Infectious Diseases, 2021.  (First author)

Qiujie Wang^#, Bin Cheng^#, Qiang Xue^#, Qingzhu Gao, Ailong Huang*, Kai Wang*, Ni Tang*, GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death & Disease, 2021. (*Co-corresponding author,)

Yi Liu^#, Haijun Deng^#, Li Liang, Guiji Zhang, Jie Xia, Keyue Ding, Ni Tang*, Kai Wang*, Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway. Genes & Diseases, 2021. (*Corresponding author，IF=7.2)

Chang-Long He^#, Lu-Yi Huang^#, Kai Wang^#, Chen-Jian Gu, Jie Hu, Gui-Ji Zhang, Wei Xu, You-Hua Xie*, Ni Tang*, Ai-Long Huang*, Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. Signal Transduction and Targeted Therapy, 2021. (^#Co-first author)

Jie Hu^# , Pai Peng^#, Kai Wang^#, Liang Fang, Fei-yang Luo, Ai-shun Jin, Bei-zhong Liu*, Ni Tang*, Ai-long Huang*, Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies. Cellular & Molecular Immunology, 2021 (^#Co-first author)

Pai Peng^#, Jie Hu^#, Hai-jun Deng, Bei-zhong Liu, Liang Fang, Kai Wang*, Ni Tang*, Ai-long Huang*, Changes of humoral immunity response in SARS-CoV-2 convalescent patients over 8 months. Cellular & Molecular Immunology, 2021. (*Co-corresponding author)

Jie Hu^#, Qingzhu Gao^#, Changlong He, Ailong Huang, Ni Tang*, Kai Wang*, Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2. Genes & Diseases, 2020. (*Corresponding author)

Jie Hu^#, Qingzhu Gao^#, Yang Yang^#, Jie Xia^#, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang*, Ailong Huang*, Ni Tang*, Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation. Theranostics, 2021. (*Co-corresponding author)

Qingzhu Gao^#, Guiji Zhang^#, Yaqiu Zheng^#, Yi Yang^#, Chang Chen, Jie Xia, Li Liang, Chong Lei, Yuan Hu, Xue-Fei Cai, Wenlu Zhang, Hua Tang, Yaxi Chen, Ailong Huang*, Kai Wang*, Ni Tang*, SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC. Cell Death & Differentiation, 2020.  (*Co-corresponding author)

Guiji Zhang^#, Xia Tang^#, Li Liang^#, Wanfeng Zhang, Dewei Li, Xiaoyuan Li, Dachun Zhao, Yaqiu Zheng, Yanhong Chen, Bingtao Hao, Kai Wang*, Ni Tang*, Keyue Ding*, DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma, Oncogene, 2020. (*Co-corresponding author)

Jin Xiang^#, Yuhong Zhang^#, Lin Tuo, Rui Liu, Dongmei Gou, Li Liang, Chang Chen, Jie Xia, Ni Tang, Kai Wang*, Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-Seq. Genes & Diseases, 2020. (Corresponding author)

Chong Lei^#, Qiujie Wang, Ni Tang*, Kai Wang*, GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells. FEBS Open Bio, 2020. (Corresponding author)

Jingjing Li^#, Qiujie Wang^#, Yi Yang, Chong Lei, Fan Yang, Li Liang, Chang Chen, Jie Xia, Kai Wang*, Ni Tang*, GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Journal of Experimental & Clinical Cancer Research, 2019.(*Co-corresponding author)

Fan Yang^#, Jingjing Li^#, Haijun Deng^#, Yihao Wang, Chong Lei, Qiujie Wang, Jin Xiang, Li Liang, Jie Xia, Xuanming Pan, Xiaosong Li, Quanxin Long, Lei Chang, Ping Xu, Ailong Huang*, Kai Wang*, Ni Tang*, GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. The EMBO Journal, 2019. (*Co-corresponding author)

Xuemei Chen^#, Yuan Hu^#, Wenlu Zhang, Ke Chen, Jie Hu, Xiaosong Li, Li Liang, Xuefei Cai, Jieli Hu, Kai Wang*, Ailong Huang*, Ni Tang*, Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radical Biology and Medicine, 2019. (*Co-corresponding author)

Lin Tuo^#, Jin Xiang^#, Xuanming Pan^#, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang*, Kai Wang*, Ni Tang*, PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27^Kip1 axis. Journal of Experimental & Clinical Cancer Research, 2019.(*Co-corresponding author)  

Lin Tuo^#, Jin Xiang^#, Xuanming Pan, Qingzhu Gao, Guiji Zhang, Yi Yang, Li Liang, Jie Xia, Kai Wang*, Ni Tang*, PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway. Frontiers in Oncology, 2018. (*Co-corresponding author)

Qingzhu Gao^#, Kai Wang^#, Ke Chen, Li Liang, Yaqiu Zheng, Yunzhi Zhang, Jin Xiang, Ni Tang *, HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma. Cancer Science, 2017. (^#Co-first author)

Kai Wang^#, Wei Lv^#, Jianfei Chen^#, Shiqi Xie, Hongyan Shi, Haojen Hsu, Wenjing Yu, Ke Xu, Chao Bian, Wolfgang B Fischer, Wolfgang Schwarz, Li Feng*, Bing Sun*, PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS Letters, 2012.

Kai Wang^#, Shiqi Xie, Bing Sun*. Viral proteins function as ion channels. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2011.

Shiqi Xie^#, Kai Wang^#, Wenjing Yu, Wei Lv, Ke Xu, Jianwei Wang, Bin Ye, Wolfgang Schwarz, Qi Jin*, Bing Sun*, DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71, Cell Research, 2011. (^#Co-first author)

Ronghua Zhang^#, Kai Wang^#, Wei Lv^#, Wenjing Yu, Shiqi Xie, Ke Xu, Wolfgang Schwarz, Sidong Xiong*, Bing Sun*, The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014. (#Co-first author)

Ronghua Zhang^#, Kai Wang, Xianqiang Ping, Wenjing Yu, Zhikang Qian, Sidong Xiong*, Bing Sun*, The ns12. 9 accessory protein of human coronavirus OC43 is a viroporin involved in virion morphogenesis and pathogenesis. Journal of Virology, 2015.

Silvia Schwarz^#, Kai Wang, Wenjing Yu, Bing Sun, Wolfgang Schwarz*, Emodin inhibits current through SARS-associated coronavirus 3a protein. Antiviral Research, 2011.

Silvia Schwarz^#, Daniel Sauter, Kai Wang, Ronghua Zhang, Bing Sun, Anastasia Karioti, Anna Rita Bilia, Thomas Efferth, Wolfgang Schwarz*, Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta medica, 2014.

Daniel Sauter^#, Silvia Schwarz, Kai Wang, Ronghua Zhang, Bing Sun, Wolfgang Schwarz*, Genistein as antiviral drug against HIV ion channel. Planta medica, 2014.

潘璇明，张桂冀，陈雪梅，梁利，唐霓，汪凯^*. 果糖-1，6-二磷酸酶1抑制肝癌细胞株HepG2的自噬及增殖. 中华肝脏病杂志, 2019.

向进，庹琳，高庆祝，杨翼，梁利，夏杰，唐霓，汪凯^*. PCK1影响肝癌细胞迁移能力的研究. 重庆医科大学学报, 2018.

龚德敖，唐霓，汪凯^*. 斑点型锌指结构蛋白在肿瘤中的作用. 生命的化学，2022.

杨佳瑶，唐霓，汪凯^*. 己糖胺生物合成途径代谢酶与OGT介导的O-GlcNAc修饰在肿瘤中的研究进展. 重庆医科大学学报，2023.