Our project on gluconeogenesis（roles of gluconeogenic enzymes in HCC and NASH） - 课题组新闻

1. Gou D, Liu R, Shan X, Deng H, Chen C, Xiang J, Liu Y, Gao Q, Li Z, Huang A, Wang K, Tang N. Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression. J Clin Invest. 2023 May 11;. doi: 10.1172/JCI161713. PubMed PMID: 37166978.

2.Ye Q, Liu Y, Zhang G, Deng H, Wang X, Tuo L, Chen C, Pan X, Wu K, Fan J, Pan Q, Wang K, Huang A, Tang N. Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice. Nat Commun. 2023 Mar 14;14(1):1402. doi: 10.1038/s41467-023-37142-3. PubMed PMID: 36918564; PubMed Central PMCID: PMC10015095.

3. Liu R, Liu Y, Zhang W, Zhang G, Zhang Z, Huang L, Tang N, Wang K, PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma. Genes & Diseases, 2023 Sep 16, doi: 10.1016/j.gendis.2023.101114

4. Xiang J, Chen C, Liu R, Gou D, Chang L, Deng H, Gao Q, Zhang W, Tuo L, Pan X, Liang L, Xia J, Huang L, Yao K, Wang B, Hu Z, Huang A, Wang K, Tang N. Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation. J Clin Invest. 2021 Apr 15;131(8). doi: 10.1172/JCI144703. PubMed PMID: 33690219; PubMed Central PMCID: PMC8262473.

5. Xiang J, Wang K, Tang N. PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities. Genes Dis. 2023 Jan;10(1):101-112. doi: 10.1016/j.gendis.2022.02.010. eCollection 2023 Jan. Review. PubMed PMID: 37013052; PubMed Central PMCID: PMC10066343.

6. Tuo L, Xiang J, Pan X, Hu J, Tang H, Liang L, Xia J, Hu Y, Zhang W, Huang A, Wang K, Tang N. PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis. J Exp Clin Cancer Res. 2019 Feb 4;38(1):50. doi: 10.1186/s13046-019-1029-y. PubMed PMID: 30717766; PubMed Central PMCID: PMC6360696.

7. Liu R, Gou D, Xiang J, Pan X, Gao Q, Zhou P, Liu Y, Hu J, Wang K, Tang N. O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis. Oncogene. 2021 Dec;40(50):6707-6719. doi: 10.1038/s41388-021-02058-z. Epub 2021 Oct 14. PubMed PMID: 34650217; PubMed Central PMCID: PMC8677624.

8. Xiang J, Zhang Y, Tuo L, Liu R, Gou D, Liang L, Chen C, Xia J, Tang N, Wang K. Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-seq. Genes Dis. 2020 Mar;7(1):150-159. doi: 10.1016/j.gendis.2019.04.004. eCollection 2020 Mar. PubMed PMID: 32181286; PubMed Central PMCID: PMC7063442.

9. Tuo L, Xiang J, Pan X, Gao Q, Zhang G, Yang Y, Liang L, Xia J, Wang K, Tang N. PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway. Front Oncol. 2018;8:611. doi: 10.3389/fonc.2018.00611. eCollection 2018. PubMed PMID: 30619751; PubMed Central PMCID: PMC6304441.

10. Lin X, Pan XM, Peng ZK, Wang K, Tang N. [Glucose-6 phosphatase catalytic subunit inhibits the proliferation of liver cancer cells by inducing cell cycle arrest]. Zhonghua Gan Zang Bing Za Zhi. 2022 Feb 20;30(2):213-219. doi: 10.3760/cma.j.cn501113-20210204-00067. PubMed PMID: 35359074.

11. Pan XM, Zhang GJ, Chen XM, Liang L, Tang N, Wang K. [Fructose-1, 6-bisphosphatase inhibits autophagy and proliferation in liver cancer cells]. Zhonghua Gan Zang Bing Za Zhi. 2019 Sep 20;27(9):687-692. doi: 10.3760/cma.j.issn.1007-3418.2019.09.006. PubMed PMID: 31594093.