李小六 - 河北大学 - 化学与环境科学学院

个人简介

教授，博士生导师；南开大学有机化学专业博士（1995~1998），日本帝京大学药学部博士后（1998~1999），日本学术振兴会研究员（JSPS Fellow）（1999~2001），日本三共株式会社药物化学研究所高级研究员（2001~2003）。现任河北大学国际合作交流处处长。主要从事糖类衍生物及新型抗肿瘤、抗病毒、抗菌和免疫调节等类药物的设计合成、活性评价、构效关系研究，超分子糖簇类功能化合物的设计合成及分子识别研究，绿色有机合成方法研究等。先后主持973计划前期专项、国家自然科学基金、教育部重点基础研究课题、河北省自然基金、日本文部省基础研究基金等课题20余项。发表 SCI论文收录100余篇，授权发明专利8项，先后获天津市自然科学二等奖、中国专利优秀奖等。

研究领域

糖化学与糖生物学、药物设计与合成、超分子化学与分子识别

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Kerang Wang, Hongwei An, Ruixue Rong, Zhiran Cao, Xiaoliu Li. Fluorescence turn-on sensing of protein based on mannose functionalized perylene bisimides and its fluorescence imaging. Biosens. Bioelectron., 2014, 58, 27–32. Kerang Wang, Hongwei An, Ruixue Rong, Zhiran Cao, Xiaoliu Li. Synthesis of biocompatible glycodendrimer based on fluorescent perylene bisimides and its bioimaging. Macromol. Rapid Comm., 2014, 35, 727–734. Hua Chen, Le Hao, Mo Zhu, Tianyu Yang, Sinan Wei, Zhanbin Qin, Pingzhu Zhang, Xiaoliu Li. Synthesis of bi-/tricyclic azasugar fused thiazinan-4-one and their HIV-RT inhibitory activity, Bioorg. Med. Chem. Lett., 2014, 24, 3426-3429. Kerang Wang, Yueqing Wang, Hongwei An, Jinchao Zhang, Xiaoliu Li. A triazatruxene-based glycoclusters as a fluorescent sensor for Concanavalin A. Chem. Eur. J., 2013, 19, 2903–2909. Kerang Wang, Hongwei An, Yueqing Wang, Jinchao Zhang, Xiaoliu Li. Multivalent glycoclusters constructed by chiral self-assembly of mannose functionalized perylene bisimide. Org. Biomol. Chem., 2013, 11, 1007–1012. Kerang Wang, Hongwei An, Feng Qian, Yueqing Wang, Jinchao Zhang, Xiaoliu Li. Synthesis, optical properties and binding interactions of a multivalent glycocluster based on a fluorescent perylenebisimide derivative. RSC Adv., 2013, 3, 23190–23196. Hua Chen, Shuai Li, Yuchao Yao, Likai Zhou, Jianpeng Zhao, Yunjing Gu, Kerang Wang, Xiaoliu Li. Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA, Bioorg. Med. Chem. Lett., 2013, 23, 4785-4789. Hua Chen, Sinan Wei, Hongbo Zhang, Xiaoliu Li*, Structure and temperature controlled synthesis of novel thiazolidin-4-one derivatives bearing an azasugar, Tetrahedron: Asymmetry, 2013, 24, 457-463. Pingzhu Zhang, Yinbo Li, Ming Liu, Yanfei Wang, Cuicui Li, Donglai Ma, Hua Chen, Kerang Wang, Xiaoliu Li, Jinchao Zhang. A convenient synthesis of amine-linked neodisaccharide derivatives based on one-pot tandem Staudinger/aza-Wittig/reduction and biological evaluation, Carbohydr. Res., 2013, 372, 15–22. Kerang Wang, Hongwei An, Ling Wu, Jinchao Zhang, Xiaoliu Li. Chiral Self-assembly of Lactose Functionalized Perylene Bisimides as Multivalent Glycoclusters. Chem. Commun., 2012, 48, 5644–5646.