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个人简介

American Cancer Society Postdoctoral Fellow, 2009, Harvard Medical School Ph.D. 2005, Massachusettes Institute of Technology B.S. 1999, University of Wisconsin - Madison

研究领域

Chemical Biology/Organic

近期论文

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"Simultaneous detection of distinct ubiquitin chain topologies by 19F NMR." Shekhawat, S. S.¤; Pham, G. H.¤; Prabakaran, J.; Strieter, E. R. ACS Chem. Biol. 2014, 9, 2229-2236. "Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains." Valkevich, E. M.; Sanchez, N. A.; Ge, Y.; Strieter, E. R. Biochemistry. 2014, 53, 4979-4989. "Chemoenzymatic Synthesis of Bifunctional Polyubiquitin Substrates for Monitoring Ubiquitin Chain Remodeling." Trang, V. H.; Rodgers, M. L.; Boyle, K. J.; Hoskins, A. A.; Strieter, E. R. Chembiochem. 2014, 15, 1563-1568. "Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structure of the Enzyme with the Substrate and Product." Shrestha, R. K.; Ronau, J. A.; Davies, C. W.; Guenette, R. G.; Strieter, E. R.; Paul, L. N.; Das, C. Biochemistry. 2014, 53, 3199-3217. "Neutron-Encoded Mass Signatures for Multiplexed Proteome Quantification." Hebert, A. S.; Merrill, A. E.; Bailey, D. J.; Westphall, M. S.; Strieter, E. R.; Pagliarini, D. J.; Coon, J. J. Nat. Methods. 2013, 10, 332-334. "Nonenzymatic Polymerization of Ubiquitin: Single-Step Synthesis and Isolation of Discrete Ubiquitin Oligomers." Trang, V. H.; Valkevich, E. M.; Minami, S.; Chen, Y.-C; Ge, Y.; Strieter, E. R. Angew. Chem. Int. Ed. 2012, 51, 13085-13088. "Forging Isopeptide Bonds Using Thiol-Ene Chemistry: Site-Specific Coupling of Ubiquitin Molecules for Studying the Activity of Isopeptidases." Valkevich, E. M.; Guenette, R. G.; Sanchez, N. A.; Chen, Y.-C.; Ge, Y.; Strieter, E. R. J. Am. Chem. Soc. 2012, 134, 6916-6919. "Unraveling the Complexity of Ubiquitin Signaling." Strieter, E. R.; Korasick, D. A. ACS Chem. Biol. 2012, 7, 52-63. tdoctoral, Graduate, and Undergraduate: “Cascade Reactions during Coronafacic Acid Biosynthesis: Elongation, Cyclization, and Functionalization during Cfa7-Catalyzed Condensation.” Strieter, E. R.; Koglin, A.; Aron, Z. D.; Walsh, C. T. J. Am. Chem. Soc. 2009, 131, 2113. “Mechanistic Studies on the Copper-Catalyzed N-arylation of Amides.” Strieter, E. R.; Bhayana, B.; Buchwald, S. L. J. Am. Chem. Soc. 2009, 131, 78. “Structural Basis for the Selectivity of the External Thioesterase of the Surfactin Synthetase.” Koglin, A.; L?hr, F.; Bernhard, F.; Rogov, V. R.; Frueh, D. P.; Strieter, E. R.; Mofid, M. R.; Güntert, P.; Wagner, G.; Walsh, C. T.; Marahiel, M. A.; D?tsch, V. Nature, 2008, 454, 907. “Water-Mediated Catalyst Preactivation: An Efficient Protocol for C-N Cross-Coupling Reactions.” Fors, B. P.; Krattiger, P.; Strieter, E. R.; Buchwald, S. L. Org. Lett. 2008, 10, 3505. "CmaE: A Transferase Shuttling Aminoacyl Groups between Carrier Protein Domains in the Coronamic Acid Biosynthetic Pathway." Strieter, E. R.; Vaillancourt, F. H.; Walsh, C. T. Biochemistry 2007, 46, 7549. “Reevaluation of the Mechanism of the Amination of Aryl Halides Catalyzed by BINAP-Ligated Palladium Complexes.” Shekhar, S.; Ryberg, P.; Hartwig, J. F.; Mathew, J. S.; Blackmond, D. G.; Strieter, E. R.; Buchwald, S. L. J. Am. Chem. Soc. 2006, 128, 3584. “Evidence for the Formation and Structure of Palladacycles During the Pd-Catalyzed C-N Bond-Forming Reaction with Catalysts Derived From Bulky Monophosphinobiaryl Ligands.” Strieter, E. R.; Buchwald, S. L. Angew. Chem. Int. Ed. 2006, 45, 925. “New Insights into Xantphos/Pd-Catalyzed C-N Bond-Forming Reactions: A Structural and Kinetic Study.” Klingensmith, L. M.; Strieter, E. R.; Barder, T. E.; Buchwald, S. L. Organometallics 2006, 25, 82. “The Role of Chelating Diamine Ligands in the Goldberg Reaction: A Kinetic Study on the Cu-Catalyzed Amidation of Aryl Iodides.” Strieter, E. R.; Blackmond, D. G.; Buchwald, S. L. J. Am. Chem. Soc. 2005, 127, 4120. “Insights into the Origin of High Activity and Stability of Catalysts Derived from Bulky, Electron-Rich Monophosphinobiaryl Ligands in the Pd-Catalyzed C-N Bond Formation.” Strieter, E. R.; Blackmond, D. G.; Buchwald, S. L. J. Am. Chem. Soc. 2003,125, 13978. "Mechanistic Insights into the Pd(BINAP) – Catalyzed Amination of Aryl Bromides: Kinetic Studies under Synthetically Relevant Conditions.” Singh, U. K.; Strieter, E. R.; Blackmond, D. G.; Buchwald, S. L. J. Am. Chem. Soc. 2002, 124, 14104. "Dioxolane-to-Bridged Acetal-to-Spiroketal via Ring-Closing Metathesis and Rearrangement: A Novel Route to 1,7- Dioxaspiro[5.5]undecanes.” Keller, V. A.; Martinelli, J. R.; Strieter, E. R.; Burke, S. D. Org. Lett. 2002, 4, 467.

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