个人简介

Dr.TomoyasuSugiyamagraduatedfromTohokuUniversityin1997,receivedanM.S.degreefromNaraInstituteofScienceandTechnologyin1999andobtainedaPh.D.degreefromOsakaUniversityin2003.AfterhispostdoctoraltrainingasaVisitingFellowattheNationalCancerInstitute/NationalInstitutesofHealth(USA)from2003to2007,heledhisowngroupatTsukubaUniversity(Japan)from2008to2013.HecontinuedhisresearchatNCI/NIHasaResearchFellowpriortojoiningShanghaiTechUniversityasanAssistantProfessorinAug2017

研究领域

ChromosomeandRNABiology

Preciseregulationofchromatindynamics(e.g.,heterochromatinassemblyandtranscriptionalgenesilencing)andRNAdegradationarecrucialforgenomestabilityandpropergeneexpressionpatternsineukaryotes.Dr.SugiyamahasmadeimportantcontributionstounderstandingthemechanismsbywhichconstitutiveandfacultativeheterochromatinassemblyaredirectedbyRNAinterference(RNAi)andaselectivemRNAdegradationpathway.However,thedetailedmechanismsarenotyetentirelyunderstood. TheSugiyamagroupmainlyusesthefissionyeastSchizosaccharomycespombeasamodelsystemtostudy(1)howRNAprocessingfactorsregulatepropergeneexpressionand(2)howRNAprocessingfactorscontrolchromosomedynamicssuchasheterochromatinassemblyandchromosomesegregation. Emergingevidenceindicatesthatdefectsinthesemechanismscauseseveraldiseasessuchascancer,diabetesandneurodegenerativedisorders.Therefore,uncoveringtheunderlyingmechanismsofRNA-mediatedregulationiscriticalforunderstandingdiseasesforwhichnewtherapeutictargetscouldleadtoalternativetreatments

近期论文

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1.FolcoH.D.,ChalamcharlaV.R., SugiyamaT.,ThillainadesanG.,ZofallM.,BalachandranV.,DhakshnamoorthyJ.,MizuguchiT.,andGrewalS.I.(2017).“Untimelyexpressionofgametogenicgenesinvegetativecellscausesuniparentaldisomy.” Nature,543(7643):126-130. 2. SugiyamaT.,ThillainadesanG.,ChalamcharlaV.R.,MengZ.,BalachandranV.,DhakshnamoorthyJ.,ZhouM.,andGrewalS.I.(2016).“EnhancerofrudimentarycooperateswithconservedRNA-processingfactorstopromotemeioticmRNAdecayandfacultativeheterochromatinassembly.”Mol.Cell,61(5):747-759.  3.ZhouY.,ZhuJ.,SchermannG.,OhleC.,BendrinK.,Sugioka-SugiyamaR.,#SugiyamaT.,and#FischerT.(2015).“ThefissionyeastMTRECcomplextargetsCUTsandunsplicedpre-mRNAstothenuclearexosome.” Nat.Commun.,6:7050.(#co-correspondingauthors) 4.#SugiyamaT.,WatanabeN.,KitahataE.,TaniT.,andSugioka-SugiyamaR.(2013).“Red5andthreenuclearporecomponentsareessentialforefficientsuppressionofspecificmRNAsduringvegetativegrowthoffissionyeast.” Nucleic.Acids.Res.,41(13):6674-6686.(#correspondingauthor) 5.#SugiyamaT. andSugioka-SugiyamaR.(2011).“Red1promotestheeliminationofmeiosis-specificmRNAsinvegetativelygrowingfissionyeast.” EMBOJ.,30(6):1027-1039.(#correspondingauthor) 6. SugiyamaT.,CamH.P.,SugiyamaR.,NomaK.,ZofallM.,KobayashiR.,andGrewalS.I.(2007).“SHREC,histonedeacetylase-andSNF2ATPase-containingcomplex,mediatesheterochromatictranscriptionalsilencing.” Cell,128(3):491-504.Erratumin:Cell(2007).129(6):1227. 7. SugiyamaT.,CamH.,VerdelA.,MoazedD.,andGrewalS.I.(2005).“RNA-dependentRNApolymeraseisanessentialcomponentofaself-enforcingloopcouplingheterochromatinassemblytosiRNAproduction.” Proc.Natl.Acad.Sci.USA,102(1):152-157. 8.CamH.P., SugiyamaT.,ChenE.S.,ChenX.,FitzGeraldP.C.,andGrewalS.I.(2005).“Comprehensiveanalysisofheterochromatin-andRNAi-mediatedepigeneticcontrolofthefissionyeastgenome.” Nat.Genet.,(Article)37(8):809-819. 9.VerdelA.,JiaS.,GerberS., SugiyamaT.,GygiS.,GrewalS.I.,andMoazedD.“RNAi-mediatedtargetingofheterochromatinbytheRITScomplex.” Science,303(5658):672-676.Erratumin:Science(2013).342(6155):193.