个人简介

1999B.S.KyotoUniversity. 2004Ph.D.KyotoUniversity. 2004-2009PostdoctoralFellowMarieCurieResearchInstitute 2009-2011JSPSSpecialPostdoctoralResearchFellowattheUniversityofCambridge 2011-2018GroupLeaderUniversityofCambridge 2018-AssistantProfessorShanghaitechUniversity

研究领域

DevelopmentalCellBiology,CellCycleRegulation,CancerBiology

Thecellcycleisoneofthemostfundamentalprocessesforlivingorganismsandthemolecularmachineryregulatingthecellcycleisevolutionallyconservedfromyeasttoman.MylaboratorycombinesadvancedgeneticmethodsandinvivoimagingofthefruitflyDrosophilamelanogasterwithproteomicsandgenomicsapproachesanddetailedmolecularanalysis,inordertouncoveruniversalmechanismsintegratingcelldivisionintodevelopmentalandhomeostaticprocessesofmulticellularorganisms(http://www.kimatalab.com/).WehaverecentlydiscoveredthatthemastercellcycleregulatorAPC/Cubiquitinligasecouplescellfatedeterminationtothecellcyclebyregulatinganextracellularsignallingpathwayandthecentrosome(Meghinietal.,2016NatureComms;Martinsetal.,2017DevCell).Weareworkingwithinternationalcollaborators:RenataBasto(InstituteCurie,France),AndreaBrand(GurdonInstitute,UK),andMarcdelaRoche(UniversityofCambridge,UK),tofurtherexploresuchcouplingmechanismsandtoapplythefindingsinfliesintomammaliansystems

近期论文

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1.MartinsT,MeghiniF,FlorioF,andKimataY(Correspondingauthor)(2017).TheAPC/CcoordinatesretinaldifferentiationwiththecellcyclethroughtheNek2-dependentmodulationofWinglesssignalling.DevelopmentalCell,40(1):67-80 2.MeghiniF,MartinsT,TaitX,FujimitsuK,YamanoH,GloverDM,andKimataY(Correspondingauthor)(2016).TargetingofFzr/CDH1fortimelyactivationoftheAPC/Catthecentrosomeduringmitoticexit.NatureCommunications,7:12607. 3.HaiderS,LipinszkiZ,PrzewlokaMR,LadakY,D'AvinoPP,KimataY,Lio'P,GloverDM(2015).DAPPER:adata-miningresourceforprotein-proteininteractions.BioDataMin.,8:30. 4.KimataY,KitamuraK,FennerN,andYamanoH(2011).Mes1controlsthemeiosisItomeiosisIItransitionbydistinctlyregulatingtheanaphase-promotingcomplex/cyclosomecoactivatorsFzr1/Mfr1andSlp1infissionyeast.Mol.Biol.Cell,22(9):1486–94. 5.KimataY,BaxterJE,FryAM,andYamanoH.(2008).ArolefortheFizzy/Cdc20familyofproteinsinactivationoftheAPC/Cdistinctfromsubstraterecruitment.MolecularCell,32(4):576–83. 6.KimataY,TrickeyM,IzawaD,GannonJ,YamamotoM,andYamanoH(2008).AmutualinhibitionbetweenAPC/CanditssubstrateMes1requiredformeioticprogressioninfissionyeast.DevelopmentalCell,14:446–454. 7.HayesMJ*,KimataY*(*equalcontribution),WattamSL,LindonC,MaoG,YamanoHandFryAM(2006).EarlymitoticdegradationofNek2AdependsonCdc20-independentinteractionwiththeAPC/C.NatureCellBiology,8:607–614