个人简介

Dr.HisashiTadakumagraduatedfromWasedaUniversityinJapanin1995,andobtainedaPh.D.degreefromWasedauniversityunderthesupervisionofProfessorTakashiFunatsuin2004.HewasanAssistantProfessorinWasedaUniversity(Funatsulab,from2001to2003),andinTheUniversityofTokyo(Tomishigelab,from2003to2008).AfterashortpostdoctoralresearchinTheUniversityofTokyo(Ueda/Taguchilab),hebecameanAssistantProfessorinTheUniversityofTokyo(TakuyaUedalab,from2010-2014).ThenhedidhissecondshortpostdoctoralresearchatthelaboratoryofProfessorYoshieHaradaatKyotoUniversity,andbecameanAssistantProfessorofHaradalabatOsakaUniversity,from2016-2019.HejoinedShanghaiTechUniversityasanAssistantProfessorinNov2019

研究领域

NanobiologybasedonSyntheticBiologyandBiophysics

Transcriptionisthefirststepofgeneexpressionandthusquiteimportant.Ourlabfocusesonunderstandingthebasicmechanismoftranscriptionandappliestheknowledgetodevelopnovelgeneexpressioncontrolnano-devices.Todothat,wewillcombineasyntheticbiologyapproach(reconstitutionofbiologicalsystems)andabiophysicalapproach(singlemoleculeimaging),andwillbuildupuniquenano-chips.Withthenano-chips,wewillmimicthetranscriptionsystemandwillunderstandtheunderlyingmechanism.Furthermore,wewilldevelopautonomousnano-devicesthatcansensetheenvironment,computeinformationandoutputproduct,allowingustheprecisecontrolofcellfate.Inthefuture,programmablegeneexpressionsystemwillopenthewaytoautonomouslycureourbody

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.YokoyamaT,MachidaK(co-1st),IwasakiW(co-1st),ShigetaT,NishimotoM,TakahashiM,SakamotoA,YonemochiM,HaradaY,ShigematsuH,ShirouzuM,*TadakumaH,*ImatakaH,*ItoT.HCVIREScapturesanactivelytranslating80Sribosome.MolecularCell74(6),1205-1214(2019) 2.MasubuchiT,*EndoM,IizukaR,IguchiA,YoonDH,Sekiguchi,TQiH,IinumaR,MiyazonoY,ShojiS,FunatsuT,*SugiyamaH,HaradaY,*UedaT,*TadakumaH.Constructionofintegratedgenelogic-chip.NatureNanotechnology13(10),933-940(2018) (ArticleinNIKKANKOGYOnewspaper(inJuly24,2018,Japanese),Nanowerk,TheMedicalNews,EurekAlert!,Phys.org,ScienceDaily) 3.TsuboyamaK,*TadakumaH,*TomariY.ConformationalActivationofArgonautebyDistinctyetCoordinatedActionsoftheHsp70andHsp90ChaperoneSystems.MolecularCell.70(4),722-729(2018) 4.*TadakumaH,MasubuchiT,UedaT.RNAStudyUsingDNANanotechnology(review).ProgMolBiolTranslSci.,139:121-163(2016) 5.YaoC,SasakiHM,UedaT,*TomariY,*TadakumaH.Single-moleculeanalysisofthetargetcleavagereactionbyDrosophilaRNAienzymecomplex.MolecularCell,59,125-132(2015) (Cover,Featuredinmini-reviewoftheissue.ArticleinNikkei-technologynewspaperinAug32015) 6.IwasakiS,SasakiHM(co-1st),SakaguchiY,SuzukiT,*TadakumaH,*TomariY.DefiningfundamentalstepsintheassemblyofDrosophilaRNAienzymecomplex.Nature,521,533-536(2015) 7.MiyazonoY,HayashiM,KaragiannisP,HaradaY,*TadakumaH.Strainthroughthenecklinkerensuresprocessiveruns:aDNA-kinesinhybridnanomachinestudy.EMBOJ.29(1):93-106(2010)