个人简介

1995-1999美国加州大学伯克利,分子细胞学，学士学位 1999-2003耶鲁大学,免疫学，博士学位 2003-2007耶鲁大学RuslanMedzhitov实验室，博士后研究 2007-2008哈佛大学医学院AnjanaRao实验室，博士后研究 2008-2014哈佛公卫学院，助理教授 2015-2018哈佛公卫学院，副教授 2018.10-至今上海科技大学，生命科学与技术学院，副教授，研究员

研究领域

巨噬细胞代谢、功能及生物学

巨噬细胞是极具动力性及调节多种生理功能的细胞。本课题组致力于研究巨噬细胞代谢，包括不同代谢途径与激活巨噬细胞的信号通路之间的相互作用，以及线粒体代谢对染色质的调控作用。课题组的研究目标在阐述细胞代谢调节巨噬细胞功能的主要机理，为多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.HargreavesDC,HorngT*,MedzhitovR*.Controlofinduciblegeneexpressionbysignal-dependenttranscriptionalelongation.*co-correspondingauthors.Cell.Jul.10,2009.PMID:19596240 2.MurakamiT,OckingerJ,YuJ,BylesV,McCollA,HoferA,andHorngT.AcriticalroleforcalciummobilizationinactivationoftheNLRP3inflammasome.PNAS.Jul.10,2012.PMID:22733741 3.BylesV*,CovarrubiasAJ*,Ben-SahraI,LammingD,SabatiniD,ManningBandHorngT.TheTSC-mTORpathwayregulatesmacrophagepolarization.*co-firstauthorship.NatureCommunications.Nov.27,2013.PMID:24280772 4.YuJ,NagasuH,MurakamiT,HoangH,BroderickL,HoffmanHMandHorngT.InflammasomeactivationleadstoCaspase-1-dependentmitochondrialdamageandblockofmitophagy.PNAS.Oct.28,2014.PMID:25313054 5.CovarrubiasAJ,AksoylarHI,YuJ,SnyderNW,WorthAJ,IyerSS,WangJ,Ben-SahraI,BylesV,StapornkulTP,EspinosaEC,LammingD,ManningBD,ZhangY,BlairIA,andHorngT.Akt-mTORC1signalingregulatesAclytointegratemetabolicinputtocontrolofmacrophageactivation.eLIFE.Feb.19,2016.PMID:26894960 ·CommentarybyTorresAetal.Immunometabolism:Metabolismfine-tunesmacrophageactivation.eLIFE.Feb19,2016.PMID:26894957 6.SogawaY,NagasuH,IwaseS,IhoriyaC,ItanoS,UchidaA,KidokoroK,TaniguchiS,TakahashiM,SatohM,Sasaki,SuzukiT,YamamotoM,HorngT,andKashiharaN.InfiltrationofM1,butnotM2,macrophagesisimpairedafterunilateralureterobstructioninNrf2-deficientmice.ScienceReports.Aug18;7(1):8801.PMID:28821730 7.MorettiJ,RoyS,BozecD,MartinezJ,ChapmanJR,UeberheideB,LammingDW,ChenZJ,HorngT,YeretssianG,GreenDR,andBlanderJM.Innatesensingofmicrobialviabilityorchestratesstress-mediatedautophagyoftheendoplasmicreticulum.Cell.Nov2;171(4):809-823.PMID:29056340 8.P.KentLangston1,AyaNambu1,JonathanJung1,2,MunehikoShibata1,H.IbrahimAksoylar1,JiahuiLei1,PeiningXu3,MaryT.Doan3,HelenJiang3,MichaelR.MacArthur1,XiaGao4,YongKong5,EdwardT.Chouchani6,JasonW.Locasale4,NathanielW.Synder3,andTiffanyHorng1,7*GlycerolphosphateshuttleenzymeGPD2regulatesmacrophageinflammatoryresponses.NatureImmunology.Inpress. 综述 1.MedzhitovRandHorngT*.Transcriptionalcontroloftheinflammatoryresponse. *co-correspondingauthors.NatureReviewsImmunology.Oct.2009.PMID:19859064 2.HorngTandHotamisligil.Linkingtheinflammasometoobesity-relateddisease.NatureMedicine.Feb.2011.PMID:21297609 3.CovarrubiasA,BylesV,andHorngT.ROSsetsthestageformacrophagedifferentiation.CellResearch.Aug.2013.PMID:23835480 4.KaganJCandHorngT.NLRP3inflammasomeactivation:CD36servesdoubleduty.NatureImmunology.Aug.2013.PMID:23867926 5.Horng,T.CalciumsignalingandmitochondrialdestabilizationinthetriggeringoftheNLRP3inflammasome.TrendsinImmunology.Jun.2014.PMID:24646829 6.CovarrubiasAJandHorngT.IL-6strikesabalanceduringmetabolicinflammation.CellMetabolism,Jun.2014.PMID:24896536 7.Horng,T.mTORtrainsheightenedmacrophageresponses.TrendsinImmunology.Jan.2015.PMID:25488670 8.CovarrubiasAJ,AksoylarHIandHorngT.ControlofmacrophagemetabolismandactivationbymTORandAktsignaling.SeminarsinImmunology.Aug.2015. 9.LangstonPK,ShibataMandHorngT.Metabolismsupportsmacrophageactivation.FrontiersinImmunology.Jan.2017.PMID:28197151. 10.OlivasJandHorngT.SugarfuelsTcellmemory.NatureCellBiology.Jan.2018.PMID：29269950. 11.JungJ,ZengH,andHorngT.Metabolismasaguidingforceforimmunity.NatureCellBiology.Inpress. 12.YanJ,WangRandHorngT.mTORisKeytoTcellTransdifferentiation.CellMetabolism.Feb.2019.PMID:30726756.