个人简介

1997-2001，南京大学，生物化学系，本科 2001-2006，中科院神经科学研究所，博士 2006-2010，美国麻省理工学院，博士后 2011-2017，清华大学，生命学院，特聘研究员，博导 2017.11-至今,上科大生命科学与技术学院，副教授、研究员

研究领域

记忆编码与存储的神经机制

实验室关注于研究哺乳动物大脑中的记忆存储、提取的相关编码规律和神经生物学机制。我们独立发展了大规模单神经元解析度的在体成像技术，寻找和追踪小鼠皮层内神经元群体在长期记忆形成于提取过程中的反应活动特征，探索脑对外界多模态环境的编码存储规律；利用多种手段，解析大脑中存储记忆的特异性神经环路以及表观遗传调控对记忆印迹细胞的作用，研究记忆的灵活性与稳定性调节机制；利用脑机接口等工程与医学手段，探索对脑损伤、脑疾病的修复治疗新方法。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Epigeneticregulatorsinmemoryanddiseases: 1.ShiguoLiu#,MiaomiaoTian#FanHe#,JianiLi#,HongXie#,WenmiaoLiu,YetingZhang,RuZhang,MingjiYi,FengyuanChe,XuMa,YiZheng,HaoDeng,GuijuWang,LangChen,XueSun,YingleiXu,JingliWang,YucuiZang,MengmengHan,XiuhaiWan,HongzaiGuan,YinlinGe,ChunmeiWu,HaiyanWang,HuiLiang,HuiLi,NiRan,ZhaochuanYang,HuanhuanHuang,YanzhaoWei,XuepingZheng,XiangrongSun,XueyingFeng,LanlanZheng,TaoZhu,WenhanLuo,QinanChen,YuzeYan,ZuzhouHuang,ZhongcuiJing,YixiaGuo,XuzhanZhang,ChristianP.Schaaf,JinchuanXing,ChuanyueWang&,FuliYu&,Ji-SongGuan&（2019）MutationsinASH1LconfersusceptibilitytoTouretteSyndrome.MolecularPsychiatry(Epubaheadofprint) 2.XinluDing,SanXiongLiu,MiaomiaoTian,WenhaoZhang,TaoZhu,DongdongLi,JiaweiWu,HaiTengDeng,YichangJia,WeiXie,HongXie&Ji-SongGuan#(2017)Activity-inducedhistonemodificationsgovernNeurexin-1mRNAsplicingandmemorypreservation.NatNeurosci.May;20(5):690-699,doi:10.1038/nn.4536 3.ZhuT,LiangC,LiD,TianM,LiuS,GaoGandGuanJS#.(2016)HistonemethyltransferaseAsh1Lmediatesactivity-dependentrepressionofneurexin-1.SciRep.6:26597. 4.GuanJS#,XieH,DingXL.(2015)Theroleofepigeneticregulationinlearningandmemory.ExpNeuro.268:30-36.(Review) 5.LiuP,ZhuT,LiangC,BaiB,GaoGJandGuanJS#.(2014)Aone-stepscreeningsystemformulti-zincfingerproteinstargetingalong-DNAsequence.SCIENTIASINICAVitae44:1061–1072 6.GuanJS*,HaggartySJ*,GiacomettiE*,DannenbergJH*,JosephN,GaoJ,NielandTJF,ZhouY,WangXY,MazitschekR,BradnerJE,DePinhoRA,JaenischRandTsaiLH.(2009)HDAC2negativelyregulatesmemoryformationandsynapticplasticity.Nature459:55-60. Neuronalcircuitsofmemoryandencodingmechanisms 7.DongLi*,GuangyuWang*,HongXie,YiHu,Ji-SongGuan#,ClausCHilgetag#(2019)Multimodalmemorycomponentsandtheirlong-termdynamicsidentifiedincorticallayersII/IIIbutnotlayerV.FrontiersinIntegrativeNeuroscience13:54 8.GuangyuWang*,LunWang*,HongXie*,WenhanLuo,YixiangWang,JunJiang,ChunXiao,FengXing,Ji-SongGuan#（2019）Switchingfromfeartonofearbydifferentneuralensemblesinmouseretrosplenialcortex.CerebralCortexMar19.pii:bhz050.doi:10.1093/cercor/bhz050 9.JunJiang,GuangyuWang,WenhanLuo,HongXie,Ji-SongGuan#.(2018)Mammillarybodyregulatesstate-dependentfearbyalternatingcorticaloscillations.SciRep.6:26597.Sep7;8(1):13471.doi:10.1038/s41598-018-31622-z 10.RuxingFu,WenhanLuo,RoyNazempour,DaxinTan,HeDing,KaiyuanZhang,LanYin,Ji-SongGuan#,XinSheng#,(2018)ImplantableandBiodegradablePoly(L-lacticacid)FibersforOpticalNeuralInterfaces,AdvancedOpticalMaterials,Feb,3(6):170094110.1002/adom.201700941 11.GuanJS#,JiangJ,XieHandLiuK-Y.(2016)HowdoesthesparsememoryEngram:Neuronsencodethememoryofaspatial-temporalevent?Front.NeuralCircuits10:61.(Review) 12.XieH,LiuY,ZhuYZ,DingXL,YangYHandGuanJS#.(2014)Invivoimagingofimmediateearlygeneexpressionrevealslayer-specificmemorytracesinthemammalianbrain.ProcNatlAcadSciUSA.111:2788-2793