个人简介

1988-1993IndianaUniversityinBloomington,Indiana,USA BSinBiology,BSinMusicandoutsidefield(Chemistry) 1993-1994FulbrightScholar,AlbrechtLudwigsUniversitätFreiberg,Freiberg,Germany. 1993-1995ResearchStudent,Max-PlanckInstituteforImmunology,Freiburg,Germany. 1996-2003PhD,UTSouthwesternMedicalCenteratDallas,Texas,USA 2003-2007Post-doctoralFellow,Max-PlanckInstituteforDevelopmentalBiology,Tübingen,Germany. 2008-2015GroupLeader,DFG-CenterforRegenerativeTherapiesDresden,TechnischeUniversitätDresden,Dresden,Germany 2015-2016GroupLeader,DepartmentofPharmacologyandToxicology,Medizisch-TheoretischesZentrum,TechnischeUniversitätDresden,Dresden,Germany.” 2016-presentadjunctaffiliationwithDepartmentofPharmacologyandToxicology,Medizisch-TheoretischesZentrum,TechnischeUniversitätDresden,Dresden,Germany. 2016-presentAssociateProfessor,PI,SchoolofLifeSciencesandTechnology,ShanghaiTech,Shanghai,China

研究领域

HeartandAppendageRegeneration

TheAntosgroupresearchestissueregeneration.Tounderstandthebiologyofregeneration,Dr.Antosisinterestedinansweringthreefundamentalquestions: 1.Howarecellsatthesiteofinjuryinducedtoregeneratelosttissues? 2.Howarecellsinvolvedinregenerationcontrolledtoproducethecorrectpattern? 3.Whatstopsregenerationoncetheappropriatesizeisreached? Thesequestionsarehighlyrelevanttotissuebioengineeringandtothestemcellbiologyofrepairorreconstructionofhumantissues.TheAntoslabusesthezebrafishtoanswerthesequestions,becausethezebrafishwillregeneratemanyofitsorgans,includingheartandappendages.Therefore,thelabcandescribeanddissectthecellandmolecularmechanismsinvolvedinthefish’sregenerationabilitiesandrelatethemtothelimitsonmammalianregeneration. AppendageRegeneration: Althoughthezebrafishfinshavedifferentarchitecturestothemammalianlimbs,theycontainalmostallthesametissuetypes(bone,mesenchyme,joints,skin,melanocytes,etc.).Thesetissuesjustarearrangedinadifferentpattern.Unlikemammalianlimbs,afterpartialloss,thezebrafishfinwillregeneratecompletely.Becausethezebrafishcanberesearchedwiththecurrentcell,geneticandmolecularresearchtools,thisregenerationmodelallowstheAntoslabtoassessthemechanismsinvolvedinhowtostart,patternandstopthestemandprogenitorcellsinvolvedinregeneratingappendages. HeartRegeneration: HealthyheartphysiologyrequirescoordinatedCa2+handlingacrossthesyncytialcardiacmuscle.Whilesingle-cellcardiomyocyteexperimentsincultureindicatehowindividualcardiomyocytesaltertheirCa2+subcellulardistributionandhandlingproperties,theyarelimitedinaddressingthesyncytialnatureofthecardiomyocytesintheheartinvivo.Thus,experimentaldissectionattheorgan,cellandmolecularlevelsareneededtounderstandhowknownandto-be-discoveredmechanismsregulatecardiacphysiologyduringheartregenerationinvivo.TheAntoslabisthereforeusingallthecurrentcellandmolecularmethods,includingreal-timeinvivozebrafishheartimaging,toaddressfundamentalquestionsaboutcardiacinjury,regenerationandfunction.

近期论文

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1.KolanowskiTJ,AntosCL,GuanK.(2017)Makinghumancardiomyocytesuptodate:Derivation,maturationstateandperspectives.doi:10.1007/s00210-017-1376-1.[Epubaheadofprint] 2.NeefS,HeijmanJ,OtteK,DewenterM,SaadatmandAR,Meyer-RoxlauS,AntosCL,BacksJ,DobrevD,WagnerM,MaierLS,El-ArmoucheA.(2017) Chroniclossofinhibitor-1diminishescardiacRyR2phosphorylationdespiteexaggeratedCaMKIIactivity. NaunynSchmiedebergsArchPharmacol. doi:10.1007/s00210-017-1376-1.[Epubaheadofprint] 3.AntosCL,KnopfF&BrandM.(2015)EncyclopediaArticle:“RegenerationofOrgansandAppendagesinZebrafish:AWindowintoUnderlyingCellularandMolecularControlMechanisms”,EncyclopediaofLifeSciences,http://www.els.net/  4.KujawskiS,LinW,KitteF,BörmelM,FuchsS,ArulmozhivarmanG,VogtS,TheilD,ZhangY&AntosCL (2014)Calcineurinregulatescoordinatedoutgrowthofzebrafishregeneratingfins.DevelopmentalCell 28:573-587  5.KizilC,KüchlerB,YanJ-J,ÖzhanG,MoroE,ArgentonF,BrandM,WeidingerG&AntosCL (2014)Simplet/Fam53b(Smp)isrequiredforWntsignaltransductionbyregulatingβ-cateninnuclearlocalization.Development 141:3529-3539.  6.KizilC,OttoGW,GeislerR,Nüsslein-VolhardC&AntosCL,(2009)Simpletcontrolscellproliferationandgenetranscriptionduringzebrafishcaudalfinregeneration.Dev.Biol.325:329-340.  7.AntosCL,Lopez-RodriguezC,SheltonJM,RichardsonJA,LinF,NovobrantsevaTI,BronsonRT,IgarashiP,RaoA&OlsonEN.(2004)LossofNFAT5resultsinrenalatrophyandlackoftonicity-responsivegeneexpressionProc.Natl.Acad.Sci.U.S.A. 101:2392-2397.  8.AntosCL,McKinseyTA,DreitzM,HollingsworthLM,ZhangCL,SchreiberK,RindtH&OlsonEN.(2003)Dose-DependentBlockadetoCardiomyocyteHypertrophybyHistoneDeacetylaseInhibitorsJ.Biol.Chem. 278:28930-28937.  9.AntosCL,McKinseyTA,FreyN,KutschkeW,McAnallyJ,SheltonJM,RichardsonJA,HillJA&OlsonEN.(2002)ActivatedGlycogenSynthase[Kinase]-3βSuppressesCardiacHypertrophyinvivo. Proc.Natl.Acad.Sci.U.S.A. 99:907-912.  10.AntosCL,FreyN,MarxSO,ReikenS,GaburjakovaM,RichardsonJA,MarksAR&OlsonEN.(2001)DilatedCardiomyopathyandSuddenDeathResultingfromConstitutiveActivationofProteinKinaseA.Circ.Res. 89:997-1004.