个人简介

1985年获得中国科技大学生物系学士学位；1988年获得中国科学院生物物理研究所硕士学位；1995年获美国麻省理工学院（MIT）生物系博士学位；1995-1998年在美国哈佛大学做博士后研究（IrvingtonFellow）. 1999.3-2004.6美国华盛顿大学助理教授（tenure-track）； 2004.7-2009.6美国华盛顿大学副教授（终身）； 2009.7-2019.8美国华盛顿大学正教授（终身）； 2019年8月底加入上海科技大学生命科学与技术学院，任终身正教授

研究领域

结构生物学与细胞信号传导

（1）Wnt信号通路的分子机制，从Wnt蛋白的合成分泌，细胞表面受体结合，穿膜信号传导，b-catenin在细胞质内的降解，到细胞核内的Wntenhanceosome的抑制和激活; （2）重要癌症治疗新靶点的分子机制与结构研究； （3）蛋白质修饰酶的结构功能关系研究； （4）蛋白质设计与蛋白质工程

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

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