研究领域
使用分子生物学、电生理记录、神经元培养及活细胞荧光成像、转录组和蛋白质组分析技术以及疾病动物模型，去解析外周神经系统相关疾病的分子机制，寻找疾病治疗的新靶点，并在此基础上进行活性分子及传统中药有效成分的筛选、药理学研究和临床实验。其研究成果以第一或通讯作者发表在 Nature、PNAS、EMBO系列等SCI杂志上，并主持多项国家及地方科研基金项目超过600万元。
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1.YongShao#,HangYuTian#,JingJingZhang#,HamedKharratiKoopaee#,XingGuo,XiaoLinZhuang,MingLiLi,HojjatAsadollahpourNanaie,ElaheDehghaniTafti,BahadorShojaei,MohammadRezaNamavar,,NargesSotoudeh,AdeolaOluwakemiAyoola,JiaLiLi,BinLiang*,AliEsmailizadeh*,ShuWang*,DongDongWu*.Genomicandphenotypicanalysesrevealmechanismsunderlyinghomingabilityinpigeon.MolBiolEvol.2019Sep10.(影响因子14.797)
2.ShuWang*#，DanZhang#,JinshengHu#,QiJia#,WeiXu,DeyuanSu,HualingSong,ZhichunXu,JianminCui,MingZhou,JianYang*,JianruXiao*.Aclinicalandmechanisticstudyoftopicalborneol-inducedanalgesia.EMBOMolMed.2017Jun;9(6):802–815.(影响因子10.293)
3.DeyuanSu#,YinNian#,FengleiZhang#,JinshengHu,JianminCui,MingZhou,JianYang*,ShuWang*.Thiazolidinereactswiththioreactivebiomolecules.FreeRadicBiolMed.2017Mar;104:272-279(影响因子6.020)
4.MinghuiLi#,XiaoyuanZhou#,ShuWang#,IoannisMichailidis,YeGong,DeyuanSu,HuanLi,XuemingLi*&JianYang*.Structureofaeukaryoticcyclic-nucleotide-gatedchannel.Nature2017Feb2;542(7639):60-65.(影响因子41.577)
5.DeyuanSu#,HongZhao#,JinshengHu#,DanTang,JianminCui,MingZhou,JianYang*,ShuWang*.TRPA1andTRPV1contributetoiodineantiseptics-associatedpainandallergy.EMBORep.2016Oct;17(10):1422-1430.(影响因子8.568)
6.ShuWang,Huai-huChuang.C-terminalDimerizationActivatestheNociceptiveTransductionChannelTransientReceptorPotentialVanilloid1.JBiolChem.2011Nov25;286(47):40601–40607.(影响因子4.773)
7.ElaineWang#,HuiLi#,ShuWang#,AlexanderYChuang,andHuai-huChuang.InductionofTRPV1desensitizationbyabiasedreceptoragonist.Channels(Austin)2011Nov-Dec;5(6):464-7.(影响因子2.140)
8.HuiLi#,ShuWang#,AlexanderY.Chuang,BruceE.Cohen,andHuai-huChuang.Activity-dependenttargetingofTRPV1withapore-permeatingcapsaicinanalog.ProcNatlAcadSciUSA.2011May17;108(20):8497-502(影响因子9.681)
9.ShuWang,KinningPoon,RobertOswald,andHuai-huChuang.DistinctModulationsofHumanCapsaicinReceptorbyProtonsandMagnesiumthroughDifferentDomains.JBiolChem.2010Apr9;285(15):11547–11556.(影响因子5.328)
10.ShuWang,Tai-RanXing,Ming-LiangTang,WuYong,Chen-ChenLi,Di-YunRuan.EffectsofCd2+ontransientoutwardanddelayedrectifierpotassiumcurrentsinacutelyisolatedrathippocampalCA1neurons.NaunynSchmiedebergsArchPharmacol.2008May;377(3):245-53.(影响因子2.830)
11.ShuWang,PuHu,Hui-LiWang,MingWang,Ju-TaoChen,Di-YunRuan.EffectsofCd2+onAMPAreceptor-mediatedsynaptictransmissioninrathippocampalCA1area.ToxicolLett.2008Feb15;176(3):215-22.(影响因子3.249)
12.ShuWang,YanGu,Hui-LiWang,Xin-MeiLi,MingWang,Li-GuangSun,Di-YunRuan.InhibitoryeffectofCd2+onglycine-inducedchloridecurrentinrathippocampalneurons.BrainResBull.2006May31;69(6):680-6.(影响因子1.684)
13.HaoSun,Hui-LiWang,ShuWang*.d-serinerelieveschronicleadexposure-impairedlong-termpotentiationintheCA1regionoftherathippocampusinvitro.NeurosciLett.2007Mar1;417(2):118-22.(影响因子2.085)
14.MinghuiLi,WeiKZhang,NicoleMBenvin,XiaoyuanZhou,DeyuanSu,HuanLi,ShuWang,IoannisEMichailidis,LiangTong,XuemingLi&JianYang*.StructuralbasisofdualCa2+/pHregulationoftheendolysosomalTRPML1channel.NatStructMolBiol.2017Mar;24(3):205-213.(影响因子13.333)
15.Ahmed,ShuWang,Huai-HuChuang,andRobertOswald.MechanismofAMPAreceptoractivationbypartialagonists:disulfidetrappingofclosedlobeconformations.JBiolChem.2011Oct7;286(40):35257-66.(影响因子4.773)
16.WuYong,Min-MinZhang,ShuWang,Di-YunRuan.Effectsofsodiumvalproateonsynaptictransmissionandneuronalexcitabilityinrathippocampus.ClinExpPharmacolPhysiol.2009Nov;36(11):1062-7.(影响因子1.936)
17.WuYong,Tai-RanXing,ShuWang,LiangChen,PuHu,Chen-ChenLi,Hui-liWang,MingWang,Ju-TaoChen,Di-YunRuan.ProtectiveEffectsofGastrodinonLead-InducedSynapticPlasticityDeficitsinRatHippocampus.PlantaMed.2009Aug;75(10):1112-7.(影响因子2.037)
18.Hui-LiWang,Xiang-TaoChen,BinYang,Fang-LiMa,ShuWang,Ming-LiangTang,Ming-GaoHao,andDi-YunRuan.Case-controlstudyofbloodleadlevelsandattentiondeficithyperactivitydisorderinChinesechildren.EnvironHealthPerspect.2008Oct;116(10):1401-6.(影响因子6.123)
19.PuHu,LeiSun,Zhi-QiangZhu,Xiao-WeiHou,ShuWang,Shan-ShanYu,Hui-LiWang,PingZhang,MingWang,Li-WenNiu,Mai-KunTeng,Di-YunRuan.CrystalstructureofNatratoxin,anovelsnakesecretedphospholipasesA2neurotoxinfromNajaatraVenominhibitingA-typeK+currents.Proteins.2008Aug;72(2):673-83.(影响因子3.419)
20.Zhi-DianNiu,Ju-TaoChen,ShuWang,MingWang,Xin-MeiLiandDi-YunRuan.InhibitionofdelayedrectifierK+currentsbycopperinacutelydissociatedrathippocampalCA1neurons.ToxicolLett.2006Sep10;165(3):289-96.(影响因子2.784)
21.Hui-LiWang,Xiang-TaoChen,LeLuo,Zhi-YiLou,ShuWang,Ju-TaoChen,MingWang,Li-GuangSunandDi-YunRuan.ReparatoryeffectsofnicotineonNMDAreceptor-mediatedsynapticplasticityinthehippocampalCA1regionofchronicallylead-exposedrats.EurJNeurosci.2006Mar;23(5):1111-9.(影响因子3.709)
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