周伟 - 复旦大学

个人简介

学习工作经历 1999.9-2003.6 复旦大学药学院本科 2003.9-2008.6 复旦大学药学院药物化学专业博士（硕博连读） 2008.7-2010.3 浙江海正药业新药研发部项目经理 2010.4-2011.10 美国Ohio University 访问学者 2011.12-至今复旦大学化学系讲师，副教授授课情况合成实验（上、下）（专业必修课，上海市重点课程）有机化学实验（全英语课程，复旦大学精品课程）药物化学（专业选修课）有机化学C（专业必修课，上海市重点课程）

研究领域

[1] 生物催化转化研究运用生物发酵及酶催化转化技术，研究皂苷类天然产物的肠道代谢途径，富集制备活性代谢产物，已获得国家1类新药II/III期临床批件1项，国内授权发明专利7项，国际授权发明专利2项。 [2] 生物活性及作用机制研究具有生物安全二级实验室（P2）和多种疾病模型，如病毒体内外模型、细菌体内外模型、真菌体内外模型、关节炎模型、肝病模型、骨质疏松模型,高血糖模型等，开展各种候选化合物的活性筛选，并运用免疫荧光、PT-PCR、Western-blot、Si-RNA等技术开展作用机制和靶点研究。

近期论文

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Jiale Lin, Zekun Wang, Ziyue Xu, Lei Wei; Yunchang Zhang, Hui Wang, Danwei Zhang, Wei Zhou*, Yuebiao Zhang, Yi Liu*; Zhanting Li*. Water-soluble flexible organic frameworks that include and deliver proteins. Journal of the American Chemical Society, 2020-02-10, DOI: 10.1021/jacs.9b13263. Haosha Tang, Yunyan Kuang, Julan Zeng, Xiaofang Li, Wei Zhou* and Yuan Lu*. Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents. RSC Advances, 2019, 9, 31474–31482. Wei Zhou, Hai Huang, Haiyan Zhu, Pei Zhou, and Xunlong Shi*. New metabolites from the biotransformation of ginsenoside Rb1 by Paecilomyces bainier sp.229 and activities in inducing osteogenic differentiation by Wnt/β-catenin signaling activation. Journal of Ginseng Research, 2018, 42, 199-207. Huan Wang, Nanye Chen, Shuru Shen, Huiyu Li, Xiangxiang Hu, Yunkai Yang,Xiaochen Yu, Li Yea, Wei Zhou*, Meiqing Feng*. Peptide TQS169 prevents osteoporosis in rats by enhancing osteogenic differentiation and calcium absorption. Journal of Functional Foods, 2018, 49,113-21. Peng Wei, Wei Yuan, Fengfeng Xue, Wei Zhou, Ruohan Li, Datong Zhang and Tao Yi*. Deformylation reaction-based probe for in vivo imaging of HOCl. Chemical Science, 2018, 9, 495-501. Tong Liu#, Wei Zhou#, and Jie Wu*. Palladium-catalyzed direct C-H functionalization of indoles with the insertion of sulfur dioxide: synthesis of 2-Sulfonated indoles. Organic letters, 2017, 19, 6638−41. Hai Huang#, Wei Zhou#, Haiyan Zhu, Pei Zhou, and Xunlong Shi*. Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs. Toxicology and Applied Pharmacology, 2017, 323, 36-43. Wei Zhou, Xiaohui Liu, Pei Zhang, Pei Zhou, and Xunlong Shi*. Effect analysis of mineral salt concentrations on nosiheptide production by Streptomyces actuosus Z-10 using response surface methodology. Molecules, 2014, 19, 15507-20. Wei Zhou, Xiaohui Liu, Li Ye, Meiqing Feng, Pei Zhou, and Xunlong Shi*. The biotransformation of astragalosides by a novel acetyl esterase from Absidia corymbifera AS2. Process Biochemistry, 2014, 49, 1464-71.