张琪 - 复旦大学

个人简介

学习工作经历 1999.9年9月至2003年7月复旦大学化学系获得学士学位 2005年9月至2010年7月中科院上海有机化学研究所获得博士学位 2010年7月至2011年2月中科院上海有机化学研究所工作，助理研究员 2011年2月至2014年5月美国伊利诺伊大学香槟分校，博士后 2014年5月至今复旦大学化学系，教授, 博士生导师获奖情况 2011 Reaxy PhD Prize, finalist

研究领域

活性多肽类化合物的化学生物学研究特殊金属酶学机制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Characterization of a C3 deoxygenation pathway reveals a key branch point in aminoglycoside biosynthesis Meinan Lv, Xinjian Ji, Junfeng Zhao, Yongzhen Li, Chen Zhang, Li Su, Wei Ding, Zixin Deng, Yi Yu* and Qi Zhang* J. Am. Chem. Soc. 2016, In press. Biosynthetic investigation of phomopsins revealed a widespread pathway for ribosomal natural products in filamentous fungi Wei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A van der Donk*, and Qi Zhang* Proc. Natl. Acad. Sci. 2016, 113, 3521-6 Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt Products. Xianjian Ji, Yongzhen Li, Youli Jia, Wei Ding, Qi Zhang* Angew Chem Int Ed Engl. 2016, 55, 3334-7 Substrate-Tuned Catalysis of the Radical S-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis Xianjian Ji, Yongzhen Li, Wei Ding, Qi Zhang* Angew Chem Int Ed Engl. 2015, 54, 9021-4 Substrate-controlled stereochemistry in enzyme catalysis Wei Ding, Yongzhen Li, and Qi Zhang* ACS Chem Biol. 2015, 10, 1590-8 Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria Qi Zhang, James R. Doroghazi, Xiling Zhao, Mark C. Walker, and Wilfred A. van der Donk* Appl. Environ. Microbiol., 2015, 81, 4339-50 High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis Qi Zhang, Xiao Yang, Huan Wang, and Wilfred A. van der Donk* ACS Chem. Biol. 2014, 9, 2686-2694 Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS Qi Zhang, Manuel A. Ortega, Yanxiang Shi, Huan Wang, Joel O. Melby, Douglas A. Mitchell, and Wilfred A. van der Donk* Proc. Natl. Acad. Sci. 2014, 111,12031-12036 Aromatic Polyketides Produced by Bacterial Iterative Type I Polyketide Synthases Qi Zhang, Bo Pang, Wei Ding, and Wen Liu* ACS Catal., 2013, 3, 1439–1447 Biosynthesis of thiopeptide antibiotics and their pathway engineering Qi Zhang and Wen Liu* Nat. Prod. Rep., 2013, 30, 218-226 Evolution of lanthipeptide synthetases Qi Zhang, Yi Yu, Juan E. Vélasquez, and Wilfred. A. van der Donk* Proc. Natl. Acad. Sci., 2012, 109, 18361-18366. Catalytic promiscuity of a bacterial α-N-methyltransferase Qi Zhang and Wilfred. A. van der Donk* FEBS Lett., 2012, 586, 3391-3397 Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS Qi Zhang, Wilfred. A. van der Donk*, and Wen Liu* Acc. Chem. Res., 2012, 45, 555-64. Complex Biotransformations Catalyzed by Radical S-Adenosylmethionine Enzymes Qi Zhang* and Wen Liu* J. Biol. Chem., 2011, 286, 30245-30252. Characterization of NocL Involved in Thiopeptide Nocathiacin I biosynthesis: A [4Fe-4S] Cluster and the Catalysis of a Radical S-Adenosylmethionine Enzyme Qi Zhang, Dandan Chen, Jin Lin, Rijing, Liao, Wei Tong, and Wen Liu* J. Biol. Chem., 2011, 286, 21287-21294. Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination. Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, and Wen Liu* Nat. Chem. Biol., 2011, 7, 154-160. [This paper was highlighted in (1) Science. 2011, 331, 1366; (2) Nat. Chem. Biol., 2011, 7, 133-134; (3) Faculty 1000, F1000.com/8771961; (4) Nature China 2011, doi: 10.1038/nchina.2011.9]

学术兼职

《Frontiers in Chemistry》杂志副主编《Science》等多个杂志特约审稿人