高明霞 - 复旦大学

个人简介

学习工作经历 2006年7月至今：复旦大学化学系工作 2018年1月至2019年1月，美国圣母大学，访问学者 2007年5月至12月，德国，慕尼黑，环境与健康国家研究中心，访问学者 2003年9月-2006年7月，复旦大学化学系获博士学位 2000年9月-2003年7月，山东师范大学化学化工与材料科学学院获硕士学位 1996年9月-2000年7月，山东师范大学化学化工与材料科学学院获学士学位获奖情况 2009年度复旦大学复华奖教金 2011荣获复旦大学十佳辅导员称号 2016年，复旦大学优秀共产党员

研究领域

1、蛋白质组学研究是后基因组时代最前沿和最热点的研究领域之一，其在生物组织样品具有组成复杂、浓度动态范围宽的特点。针对这一问题，多年来我们在二维高效液相色谱分离系统的研发方面开展了系列工作。开发了从肽段、蛋白质到蛋白质复合物的大规模高通量的分离分析方法。并进一步发展多种复合材料对多种蛋白质的翻译后修饰（糖基化、磷酸化、棕榈酰化等）进行了富集分离以及定性定量分析。 2、研究表明循环肿瘤细胞（CTCs）被视为癌症研究的标志物，它与癌症的扩散和转移密切相关，发展针对CTCs的液体活检技术对于癌症的早期诊断与治疗具有决定性的意义。为此，我们进行了系列研究，开发多种用于CTC捕获的材料与方法，同时研发了多种高灵敏度的检测方法（SERS、MALDI等技术）。 3、在外泌体的分离分析方面开发的一系列研究方法，研究了具有不同大小的亚组。不同亚组的外泌体在细胞间交流扮演者不同的角色，了解这种尺寸的异质性有助于我们对外泌体更深层次的理解。进一步研究基于指纹图谱的人工智能用于癌症诊断。

近期论文

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Haoyang Zheng, Sheng Guan Wang, Xuantang Wang, Mingxia Gao*, Xiangmin Zhang, Deconstruction of Heterogeneity of Size-Dependent Exosome Subpopulations from Human Urine by Profiling N‑Glycoproteomics and Phosphoproteomics Simultaneously. Anal. Chem. 2020, 92, 9239−9246 Rongrong Jin, Jiaxi Wang, Mingxia Gao*, Xiangmin Zhang, Aminophenylboronic Acid-Functionalized Thorny-Trap-Shaped Monolayer Microarray for Efficient Capture and Release of Circulating Tumor Cells. Analytical Chemistry, 2020, 92, 3403−3408 Zhi Huang, Guoquan Yan, Mingxia Gao*, and Xiangmin Zhang*, Array-Based Online Two Dimensional Liquid Chromatography System Applied to Effective Depletion of High-Abundance Proteins in Human Plasma, Anal. Chem. 2016, 88, 2440-2445 Haoyang Zheng, Jiaxi Wang, Mingxia Gao*, Xiangmin Zhang, Titanium(IV)-functionalized zirconium-organic frameworks as dual-metal affinity probe for recognition of endogenous phosphopeptides prior to mass spectrometric quantification，Microchimica Acta, 2019, 186:829. Jiaxi Wang, Jie Li, Mingxia Gao*, Xiangmin Zhang, Preparation of thickness-controlled Mg-MOFs based magnetic graphene composite as a novel hydrophilic matrix for the effective identification of glycopeptide in human urine. Nanoscale, 2019, 11, 3701 - 3709 Jiaxi Wang, Jie Li, Mingxia Gao**, Xiangmin Zhang*, Recent advances in covalent organic frameworks for separation and analysis of complex samples, Trends in Analytical Chemistry, 2018, 108, 98-109 Jiaxi Wang, Jie Li, Mingxia Gao*, Xiangmin Zhang, Self-assembling covalent organic framework functionalized magnetic graphene hydrophilic biocomposites as an ultrasensitive matrix for N-linked glycopeptide recognition, Nanoscale, 2017, 9, 10750–10756 Changlong Sun, Mingxia Gao*, Xiangmin Zhang, Surface-enhanced Raman scattering (SERS) imaging-guided real-time photothermal ablation of target cancer cells using polydopamine-encapsulated gold nanorods as multifunctional agents, Anal Bioanal Chem, 2017, 409:4915–4926 Yanan Wang, Jiaxi Wang, Mingxia Gao*, Xiangmin Zhang, Functional dual hydrophilic dendrimer-modified metal-organic framework for the selective enrichment of N-glycopeptides， Proteomics, 2017, 17(10), 1700005 Jiaxi Wang, Jie Li, Yanan Wang, Mingxia Gao*, Xiangmin Zhang, Pengyuan Yang, Development of Versatile Metal−Organic Framework Functionalized Magnetic Graphene Core−Shell Biocomposite for Highly Specific Recognition of Glycopeptides, ACS Appl. Mater. Interfaces 2016, 8, 27482-27489. Ling Zhang, Ren Zhang, Mingxia Gao*, Xiangmin Zhang*, Facile synthesis of thiol and alkynyl contained SERS reporter molecular and its usage in assembly of polydopamine protected bioorthogonal SERS tag for live cell imaging. Talanta, 2016,158, 315-321. Zhi Huang, Guoquan Yan, Mingxia Gao*, and Xiangmin Zhang*, Array-Based Online Two Dimensional Liquid Chromatography System Applied to Effective Depletion of High-Abundance Proteins in Human Plasma, Anal. Chem. 2016, 88, 2440-2445 Jiaxi Wang, Yanan Wang, Mingxia Gao*, Xiangmin Zhang, Pengyuan Yang, Versatile metal-organic framework- functionalized magnetic grapheme nanoporous composites: as deft matrix for high-effective extraction and purification of the N-linked glycans, Analytica Chimica Acta 2016, 932 41-48. Jiaxi Wang, Jie Li, Mingxia Gao*, Xiangmin Zhang, Chunhui Deng, A novel double-component MOAC honeycomb composite with pollen grains as a template for phosphoproteomics research, Talanta, 2016, 154,141-149 Yanan Wang, Jiaxi Wang, Mingxia Gao*, Xiangmin Zhang*, An Ultra Hydrophilic Dendrimer-Modified Magnetic Graphene with a Polydopamine Coating for Selective Enrichment of Glycopeptides, Journal of Materials Chemistry B, 2015, 3, 8711-8716 Jiaxi Wang, Yanan Wang, Mingxia Gao*, Xiangmin Zhang*, Pengyuan Yang, Multilayer Hydrophilic Poly(phenol-formaldehyde resin)-Coated Magnetic Graphene for Boronic Acid Immobilization as a Novel Matrix for Glycoproteome Analysis, ACS Appl. Mater. Interfaces 2015, 7, 16011−16017 Changlong Sun, Ling Zhang, Ren Zhang, Mingxia Gao*, Xiangmin Zhang*, Facilely synthesized polydopamine encapsulated surface-enhanced Raman scattering (SERS) probes for multiplex tumor associated cell surface antigen detection using SERS imaging, RSC Adv., 2015, 5, 72369–72372 Peng Zhang, Ren Zhang, Mingxia Gao*, Xiangmin Zhang*, Novel Nitrocellulose Membrane Substrate for Efficient Analysis of Circulating Tumor Cells Coupled with Surface-Enhanced Raman Scattering Imaging, ACS Appl. Mater. Interfaces 2014, 6, 370−376