张凡 - 复旦大学

个人简介

Fan Zhang received his Ph.D. degree in 2008 from Fudan University followed by more than 2 years postdoctoral experience (2008-2010) from the prestigious, world leading laboratories in University of California at Santa Barbara (Galen. D. Stucky's group) before joining as an associate professor in the Chemistry Department of Fudan University in 2010. He became a full professor in Fudan University since 2013. Prof. Zhang has authored a number of book chapters, patents and more than 90 peer-reviewed research papers in international journals with the high impact factors i.e. Nat. Nanotechnol., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nano Lett., Adv. Mater., ACS Nano, Small, Chem. Mater..

研究领域

Our vision in integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, namely how micro/nano-fabrication can help solve problems in life sciences (such as diagnostics, therapeutics, and tissue engineering), and how we can learn more from life science to solve important problems in micro/nano-science and engineering (such as bio-inspired self-assembly, etc.). This is schematically shown below. Molecular Bioimaging For the past few decades, fluorescence imaging mainly locates in the visible to NIR-I region (650 - 950 nm). The short wavelength (< 1000 nm) results in poor photon penetration depth. Compared with the visible and NIR-I light, second near-infrared (NIR-II, 1000 - 1700 nm) light can penetrate more deeply into biological tissues as less light is scattered at this long-wavelength window. NIR-II molecular fluorophore is the cornerstone of NIR-II fluorescence imaging. Recent years have witnessed a fast-increasing shift to the use of NIR-II fluorophores for in vivo imaging. Instrumentation for Bioimaging Engineer imaging and spectroscopic instruments for in vitro and in vivo quantitative detections. Engineer instruments for optical Molecular imaging.

近期论文

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NIR-II Fluorescence Sensor Based on Steric Hindrance Regulated Molecular Packing for In Vivo Epilepsy Visualization Mengyao Zhao, Weiping Lai, Benhao Li, Tianwen Bai, Chunyan Liu, Yanfei Lin, Shixuan An, Longhua Guo, Lei Li, Jianbo Wang* and Fan Zhang* Angew. Chem. Int. Ed., 2024, e202403968 DOI: doi. org/10.1002/anie.202403968 2X-Rhodamine: A Bright and Fluorogenic Scaffold for Developing Near-Infrared Chemigenetic Indicators Wenxiao Wu, Kui Yan, Zuyang He, Lu Zhang, Yuyao Dong, Bin Wu, Hongyue Liu, Shangfeng Wang* and Fan Zhang* J. Am. Chem. Soc., 2024 DOI: doi. org/10.1021/jacs.4c03485 Noninvasive In Vivo Microscopy of Single Neutrophils In The Mouse Brain Via NIR-II Fluorescent Nanomaterials Ying Chen, Yiwei Yang, and Fan Zhang* Nature Protocols, 2024 DOI: doi.org/10.1038/s41596-024-00983-3 Ultra-Photostable Small-Molecule Dyes Facilitate Near-Infrared Biophotonics Kui Yan#, Zhubin Hu#, Peng Yu, Zuyang He, Ying Chen, Jiajian Chen, Haitao Sun*, Shangfeng Wang*, and Fan Zhang*Nature Communications, 2024, 15, 2593. DOI: doi.org/10.1038/s41467-024-46853-0 Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region Yang Yang, Qunying Jiang, and Fan Zhang* Chem. Rev., 2023 DOI: doi.org/10.1021/acs.chemrev.3c00506 An Extended NIR-II Superior Imaging Window from1500 to1900nm for High-resolution in vivo Multiplexed Imaging based on Lanthanide Nanocrystals Zi-Han Chen, Xiaohan Wang, Mingzhu Yang, Jiang Ming, Baofeng Yun, Lu Zhang, Xusheng Wang, Peng Yu, Jing Xu, Hongxin Zhang*, Fan Zhang* Angew. Chem. Int. Ed., 2023, e202311883 DOI: doi.org/10.1002/anie.202311883 Fluorescence-Amplified Nanocrystals in the Second Near-Infrared Window For In Vivo Real-Time Dynamic Multiplexed Imaging Yiwei Yang, Ying Chen, Peng Pei, Yong Fan*, Shangfeng Wang, Hongxin Zhang, Dongyuan Zhao, Bin-zhi Qian, and Fan Zhang* Nature Nanotechnology, 2023, 18, 1195-1204 DOI: 10.1038/s41565-023-01422-2 Activatable NIR-II Lanthanides-Polymetallic Oxomolybdate Hybrid Nanosensors for Monitoring Chemotherapy Induced Enteritis Yuanjin Zhan#, Peng Yu#, Xiaohan Wang, Yang Xie*, Hongxin Zhang*, and Fan Zhang* Adv. Funct. Mater.2023, 33, 36, 2301683 DOI: 10.1002/adfm.202301683 Expanding NIR-II Lanthanide Toolboxes for Improved Biomedical Imaging and Detection Xinyan Zhu, Hongxin Zhang*, and Fan Zhang* Acc. Mater. Res. 2023, 4, 6, 536-547 DOI: 10.1021/accountsmr.2c00117 Molecular-Based FRET Nanosensor with Dynamic Ratiometric NIR-IIb Fluorescence for Real-Time In Vivo Imaging and Sensing Ting Wang, Ying Chen, Zuyang He, Xiaohan Wang, Shangfeng Wang, and Fan Zhang* Nano Lett., 2023, 23, 10, 4548-4556 DOI: 10.1021/acs. nanolett.3c00983 Noninvasive Early Diagnosing of Allograft Rejection by a Granzyme B Protease Responsive NIR-II Bioimaging Nanosensor Ying Chen#, Peng Pei#, Yiwei Yang, Hongxin Zhang and Fan Zhang* Angew. Chem. Int. Ed. , 2023, 135, e202301696 DOI: doi.org/10.1002/anie.202301696 A self-charging salt water battery for antitumor therapy Jianhang Huang+, Peng Yu+, Mochou Liao, Xiaoli Dong, Jie Xu, Jiang Ming, Duan Bin, Yonggang Wang, Fan Zhang*and Yongyao Xia* Sci. Adv. 2023, 9, adf3992 DOI: 10.1126/sciadv.adf3992 Near-infrared luminescence high-contrast in vivo biomedical imaging Ying Chen, Shangfeng Wang and Fan Zhang* Nature Reviews Bioengineering, 2023, 1, 60–78 DOI: doi.org/10.1038/s44222-022-00002-8 Tailored NIR-II Lanthanide Luminescent Nanocrystals for Improved Biomedical Application Mengyao Zhao, Attila Sik, Hongxin Zhang,* and Fan Zhang* Adv. Optical Mater. 2022, 11, 2202039 DOI: 10.1002/adom.202202039 NIR-II Dyad-Doped Ratiometric Nanosensor with Enhanced Spectral Fidelity in Biological Media for In Vivo Biosensing Peng Yu, Kui Yan, Shangfeng Wang,* Chenzhi Yao, Zuhai Lei, Yaohui Tang, and Fan Zhang* Nano Lett., 2022, 22, 23, 9732-9740 DOI: doi.org/10.1021/acs.nanolett.2c04084 Transcranial Non-genetic Neuromodulation Via Bioinspired Vesicle-Enabled Precise NIR-II Optical-stimulation Ya Zhang+, Deqi Yang+, Jianfang Nie, Jing Dai, Haofan Wu, Jialin Charles Zheng, Fan Zhang*, andYin Fang* Adv. Mater., 2022, 35, 2208601 DOI: doi.org/10.1002/adma.202208601 Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging Hanchen Shen+, Feiyi Sun+, Xinyan Zhu+, Jianyu Zhang, Xinwen Ou, Jianquan Zhang, Changhuo Xu, Herman H. Y. Sung, Ian D. Williams, Sijie Chen, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Fan Zhang* and Ben Zhong Tang* J. Am. Chem. Soc. 2022, 144, 33, 15391-15402 DOI: doi.org/10.1021/jacs.2c07443 Luminescence Lifetime Imaging Based on Lanthanide Nanoparticles Xinyan Zhu+, Xiaohan Wang+, Hongxin Zhang* and Fan Zhang* Angew. Chem. Int. Ed. , 2022, 61, e202209378 DOI: doi.org/10.1002/anie.202209378 Stable Monodisperse Pb1-xCdxS Quantum Dots for NIR-II Bioimaging by Aqueous Coprecipitation of Bimetallic Clusters Hui Zhang+, Caixia Sun+, Libo Sun+, Wenhao Xu, Wenxiao Wu, Jie Chen, Binhang Wang, Junlai Yu, Pengfei Cui, Fan Zhang* and Yun Tang* Angew. Chem. Int. Ed. , 2022, 61, e202203851 DOI: 10.1002/anie.202203851 A deep tissue optical sensing Lingfei Lu and Fan Zhang* Nature Nanotechnology, 2022, 17, 566–568 DOI: 10.1038/s41565-022-01132-1 Counterion-paired Bright Heptamethine Fluorophores with NIR-II Excitation and Emission Enable Multiplexed Biomedical Imaging Yang Yang#, Caixia Sun#, Shangfeng Wang*, Kui Yan, Mengyao Zhao, Bin Wu and Fan Zhang* Angew. Chem. Int. Ed. , 2022, 61, e202117436 DOI: doi.org/10.1002/anie.202117436 NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring Peng Pei#, Hongxing Hu#, Ying Chen#, Shangfeng Wang, Jing Chen, Jiang Ming, Yiwei Yang, Caixia Sun, Shichang Zhao*and Fan Zhang* Nano Lett., 2022, 2, 783–791 DOI:doi.org/10.1021/acs.nanolett.1c04356 A Bright, Renal-Clearable NIR-II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging Chenzhi Yao#, Ying Chen#, Mengyao Zhao, Shangfeng Wang, Bin Wu, Yiwei Yang, Dongrui Yin, Peng Yu, Hongxin Zhang and Fan Zhang* Angew. Chem. Int. Ed. , 2022, 61, e202114 DOI:doi.org/10.1021/acs.nanolett.1c04356 One-pot preparation of highly dispersed NIR-II J-aggregates nanoparticles based on FD-1080 cyanine dye for bioimaging and biosensing Caixia Sun#, Mengyao Zhao#, Xinyan Zhu, Peng Pei and Fan Zhang* CCS Chemistry , 2022, 4, 476–486 doi.org/10.31635/ccschem.021.202101332 ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing Xin Zhang,Ying Chen,Haisheng He,Shangfeng Wang,Zuhai Lei* and Fan Zhang* Angew. Chem. Int. Ed. , 2021, 60, 26337 –2634 DOI:10.1002/anie.202109728 Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion Xuan Liu#, Heming Chen#, Yiting Wang#, Yueguang Si, Hongxin Zhang, Xiaomin Li*, Zhengcheng Zhang, Biao Yan, Su Jiang, Fei Wang, Shijun Weng, Wendong Xu, Dongyuan Zhao, Jiayi Zhang* and Fan Zhang* Nature Communications, 2021, 12, 5662 doi.org/10.1038/s41467-021-25993-7 High-fidelity NIR-II multiplexed lifetime bioimaging with bright double interfaced lanthanide nanoparticles Xinyan Zhu, Xuan Liu, Hongxin Zhang*, Mengyao Zhao, Peng Pei, Ying Chen, Yiwei Yang, Lingfei Lu, Peng Yu, Caixia Sun, Jiang Ming, István ábrahám, Ahmed Mohamed El-Toni, Aslam khan and Fan Zhang* Angew. Chem. Int. Ed. , 2021, 60, 23545 –23551 DOI:10.1002/anie.202108124 A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging Ting Wang+, Shangfeng Wang+*, Zhiyong Liu+, Zuyang He, Peng Yu, Mengyao Zhao, Hongxin Zhang, Lingfei Lu, Zhengxin Wang, Ziyu Wang, Weian Zhang*, Yong Fan, Caixia Sun, Dongyuan Zhao, Weimin Liu, Jean-Claude G. Bünzli and Fan Zhang* Nature Materials , 2021, 20, 1571–1578 DOI:10.1038/s41563-021-01063-7 NIR-II Cell Endocytosis-Activated Fluorescent Probes For In Vivo High-Contrast Bioimaging Diagnostics Yue He+, Shangfeng Wang+*, Peng Yu+, Kui Yan, Jiang Ming, Chenzhi Yao, Zuyang He, Ahmed Mohamed El-Toni, Aslam Khan, Xinyan Zhu, Caixia Sun, Zuhai Lei and Fan Zhang* Chemical Science , 2021, 12, 10474-10482 doi.org/10.1039/D1SC02763H X-ray-activated persistent luminescence nanomaterials for NIR-II imaging Peng Pei, Ying Chen, Caixia Sun, Yong Fan*, Yanmin Yang*, Xuan Liu, Lingfei Lu, Mengyao Zhao, Hongxin Zhang, Dongyuan Zhao, Xiaogang Liu, Fan Zhang* Nature Nanotechnology , 2021, 16, 1011–1018 DOI:10.1038/s41565-021-00922-3 Azo Pigments Make Raman Spectral Multiplexing More Sensitive Shangfeng Wang, Fan Zhang* ACS Cent. Sci. , 2021, 7, 5, 709–711 doi.org/10.1021/acscentsci.1c00527 A Promising NIR‐II Fluorescent Sensor for Peptide‐Mediated Long‐term Monitoring of Kidney Dysfunction Ying Chen, Peng Pei, Zuhai Lei, Xin Zhang, Dongrui Yin, Fan Zhang* Angew. Chem. Int. Ed. , 2021, 60, 15809–15815 doi.org/10.1002/anie.202103071 NIR‐II J‐Aggregates Labelled Mesoporous Implant for Imaging‐Guided Osteosynthesis with Minimal Invasion Caixia Sun, Xiaofei Sun, Peng Pei, Haisheng He, Jiang Ming, Xuan Liu, Minchao Liu, Yuntong Zhang, Yan Xia, Dongyuan Zhao, Xiaomin Li*, Yang Xie*, Fan Zhang* Adv. Funct. Mater. , 2021, 2100656 doi.org/10.1002/adfm.202100656 Near-infrared luminescent probes for bioimaging and biosensing Fan Zhang*, Benzhong Tang* Chem. Sci., 2021, 12, 3377-3378 doi.org/10.1039/D1SC90046C Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery Lishuai Feng+, Chaoran Dou+, Yuguo Xia +, Benhao Li, Mengyao Zhao, Peng Yu, Yuanyi Zheng, Ahmed Mohamed El-Toni, Nada Farouk Atta, Ahmed Galal, Yingsheng Cheng*, Xiaojun Cai*, Yan Wang*, and Fan Zhang* ACS Nano., 2021, 15(2), 2263–2280 doi.org/10.1021/acsnano.0c07973 Independent Luminescent Lifetime and Intensity Tuning of Upconversion Nanoparticles by Gradient Doping for Multiplexed Encoding Xuan Liu, Zihan Chen, Hongxin Zhang, Yong Fan*, Fan Zhang* Angew. Chem. Int. Ed., 2021, 60(13), 7041-7045 doi.org/10.1002/anie.202015273 NIR-II pH Sensor with FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization Mengyao Zhao+, Jianbo Wang+*, Zuhai Lei, Lingfei Lu, Shangfeng Wang, Hongxin Zhang, Benhao Li, and Fan Zhang* Angew. Chem. Int. Ed., 2021, 60(10), 5091-5095 doi.org/10.1002/anie.202012021 Activatable Fluorescence Sensors for in vivo Bio-detection in the Second Near-infrared Window Mengyao Zhao, Benhao Li, Hongxin Zhang*, Fan Zhang* Chem. Sci., 2021,12, 3448-3459 doi.org/10.1039/D0SC04789A Bright and Stable NIR‐II J‐aggregated AIE Dibodipy for Dynamic in vivo Bioimaging Qisong Zhang, Peng Yu, Yong Fan*, Caixia Sun, Haisheng He, Xuan Liu, Lingfei Lu, Mengyao Zhao, Hongxin Zhang, Fan Zhang* Angew. Chem. Int. Ed., 2021, 60(8), 3967-3973 doi.org/10.1002/anie.202012427 Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection Zuhai Lei, Fan Zhang* Angew.Chem. Int. Ed. 2021, 60,16294–16308 doi.org/10.1002/anie.202007040 Enhancement of Nanozyme Permeation by Endovascular Interventional Treatment to Prevent Vascular Restenosis via Macrophage Polarization Modulation Lishuai Feng+, Chaoran Dou+, Yuguo Xia+, Benhao Li, Mengyao Zhao, Ahmed Mohamed El‐Toni, Nada Farouk Atta, Yuanyi Zheng, Xiaojun Cai*, Yan Wang*, Yingsheng Cheng*, Fan Zhang* Adv. Funct. Mater., 2020, 2006581 doi.org/10.1002/adfm.202006581 NIR-II Bioluminescence for In Vivo High Contrast Imaging and In Situ ATP-Mediated Metastases Tracing Lingfei Lu, Benhao Li, Suwan Ding, Yong Fan*, Shangfeng Wang, Caixia Sun, Mengyao Zhao, Chun-Xia Zhao, Fan Zhang* Nat. Commun., 2020, 11, 4192 doi.org/10.1038/s41467-020-18051-1 Recent Advances for Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve Preservation Ying Chen, Hongxin Zhang, Zuhai Lei, Fan Zhang* Small Structures, 2020,1, 2000036 doi.org/10.1002/sstr.202000036 Exploiting Molecular Probes to Perform Near‐Infrared Fluorescence‐Guided Surgery Yifan Wu, Fan Zhang* VIEW., 2020, 20200068 doi.org/10.1002/VIW.20200068 Molecular Fluorophores for Deep-Tissue Bioimaging Shangfeng Wang, Benhao Li, Fan Zhang* ACS Cent. Sci., 2020,6, 8, 1302–1316 doi.org/10.1021/acscentsci.0c00544 NIR‐II Chemiluminescence Molecular Sensor for In‐Vivo High Contrast Inflammation Imaging Yanling Yang, Shangfeng Wang, Lingfei Lu, Qisong Zhang, Peng Yu, Yong Fan*, Fan Zhang* Angew. Chem. Int. Ed., 2020,59, 18380 –18385 doi.org/10.1002/anie.202007649 Recent Progress in NIR-II Emitting Lanthanide-Based Nanoparticles and Their Biological Applications Suwan Ding, Lingfei Lu, Yong Fan*, Fan Zhang* Journal of Rare Earths, 2020, 38(5), 451-463 doi.org/10.1016/j.jre.2020.01.021 Rational Designing of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing Benhao Li, Mengyao Zhao, Fan Zhang* ACS Materials Lett. , 2020, 2, 905-917 doi.org/10.1021/acsmaterialslett.0c00157 A Mini-Review on Recent Progress of New Sensitizers for Luminescence of Lanthanide Doped Nanomaterials Hongxin Zhang, Zi-Han Chen, Xuan Liu, Fan Zhang* Nano Res. , 2020, 13, 1795-1809 doi.org/10.1007/s12274-020-2661-8 Organic NIR-II Molecule with Long Blood Half-Life for In Vivo Dynamic Vascular Imaging Benhao Li+, Mengyao Zhao+, Lishuai Feng, Chaoran Dou, Suwan Ding, Gang Zhou, Lingfei Lu, Hongxin Zhang, Feiya Chen, Xiaomin Li, Guangfeng Li, Shichang Zhao, Chunyu Jiang, Yan Wang, Dongyuan Zhao, Yingsheng Cheng, Fan Zhang* Nat. Commun., 2020, 11, 3102 doi.org/10.1038/s41467-020-16924-z A Tumor‐Microenvironment‐Responsive Lanthanide–Cyanine FRET Sensor for NIR‐II Luminescence‐Lifetime In Situ Imaging of Hepatocellular Carcinoma Mengyao Zhao+, Benhao Li+, Yifan Wu, Haisheng He, Xinyan Zhu, Hongxin Zhang, Chaoran Dou, Lishuai Feng, Yong Fan, Fan Zhang* Adv. Mater., 2020, 32(28), 2001172 doi.org/10.1002/adma.202001172 J-aggregates of Cyanine Dye for NIR-II In-vivo Dynamic Vascular Imaging Beyond 1500 nm Caixia Sun+, Benhao Li+, Mengyao Zhao, Shangfeng Wang, Zuhai Lei, Lingfei Lu, Hongxin Zhang, Lishuai Feng, Chaoran Dou, Dongrui Yin, Huixiong Xu, Yingsheng Cheng, Fan Zhang* J. Am. Chem. Soc., 2019, 141(49), 19221-19225 doi.org/10.1021/jacs.9b10043 Manganese Oxide Nanoclusters for Skin Photoprotection Lin Xiong, Mengyao Zhao, Yong Fan, Shangfeng Wang, Yanling Yang, Xiaomin Li, Dongyuan Zhao and Fan Zhang* ACS Appl. Bio Mater., 2019, 2(9), 3974-3982 10.1021/acsabm.9b00528 Elemental Migration in Core/Shell Structured Lanthanide Doped Nanoparticles Lu Liu, Xiaomin Li*, Yong Fan, Changyao Wang, Ahmed Mohamed El-Toni, Mansour Saleh Alhoshan, Dongyuan Zhao, and Fan Zhang* Chem. Mater., 2019, 31(15), 5608-5615 10.1021/acs.chemmater.9b01348 Tm3+‐Sensitized NIR‐II Fluorescent Nanocrystals for In?Vivo Information Storage and Decoding Hongxin Zhang, Yong Fan, Peng Pei, Caixia Sun, Lingfei Lu, and Fan Zhang* Angew. Chem. Int. Ed., 2019, 58(30), 10153-10157 10.1002/anie.201903536 In Vivo Assembly and Disassembly of Probes to Improve Near‐Infrared Optical Bioimaging Mengyao Zhao, Benhao Li, Yong Fan, Fan Zhang* Adv. Healthcare. Mater., 2019, 8(13), 1801650 10.1002/adhm.201801650 Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for in‐vivo High‐Contrast Bioimaging and Multiplexed Biosensing Zuhai Lei, Caixia Sun, Peng Pei, Shangfeng Wang, Dandan Li, Xin Zhang, Fan Zhang* Angew. Chem. Int. Ed., 2019, 58(24), 8166-8171 10.1002/anie.201904182 Optical Multiplexed Bioassays Improve Biomedical Diagnostics Yong Fan, Shangfeng Wang, and Fan Zhang* Angew. Chem. Int. Ed., 2019,58,13208 –13219 10.1002/anie.201901964 Beyond 1000 nm Emission Wavelength: Recent Advances in Organic and Inorganic Emitters for Deep‐Tissue Molecular Imaging Feng Ding+, Yong Fan+, Yao Sun*, and Fan Zhang* Adv. Healthcare Mater., 2019, 8(14), 1900260 10.1002/adhm.201900260 In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission Shangfeng Wang, Lu Liu, Yong Fan, Ahmed Mohamed El-Toni, Mansour Saleh Alhoshan, Dandan Li, and Fan Zhang* Nano Lett., 2019, 19(4), 2418-2427 10.1021/acs.nanolett.8b05148 Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring Dandan Li, Shangfeng Wang, Zuhai Lei, Caixia Sun, Ahmed Mohamed El-Toni, Mansour Saleh Alhoshan, Yong Fan, Fan Zhang* Anal. Chem., 2019, 91(7), 4771–4779 10.1021/acs.analchem.9b00317 Exploiting lanthanide-doped upconversion nanoparticles with core/shell structures Yong Fan, Lu Liu, Fan Zhang* Nano Today, 2019, 25, 68-84 10.1016/j.nantod.2019.02.009 Anti-quenching NIR-II Molecular Fluorophores for in vivo High-contrast Imaging and pH Sensing Shangfeng Wang, Yong Fan, Dandan Li, Caixia Sun, Zuhai Lei, Lingfei Lu, Ting Wang, Fan Zhang* Nat. Commun., 2019, 10, 1058 10.1038/s41467-019-09043-x A New Generation of NIR‐II Probes: Lanthanide‐Based Nanocrystals for Bioimaging and Biosensing Yong Fan, Fan Zhang* Adv. Optical. Mater., 2019, 7(7), 1801417 10.1002/adom.201801417 Precise in vivo Inflammation Imaging Using in‐situ Responsive Cross‐linking of Glutathione Modified Ultra‐Small NIR‐II Lanthanide Nanoparticles Mengyao Zhao+, Rui Wang+, Benhao Li, Yong Fan, Yifan Wu, Xinyan Zhu and Fan Zhang* Angew. Chem. Int. Ed., 2019, 58(7), 2050-2054 10.1002/anie.201812878 Supramolecularly Engineered NIR-II and Upconversion Nanoparticles In-vivo Assembly and Dis-assembly to Improve Bioimaging Mengyao Zhao, Benhao Li, Peiyuan Wang, Lingfei Lu, Zhengcheng Zhang, Lu Liu, Shangfeng Wang, Dandan Li, Rui Wang, Fan Zhang* Adv. Mater., 2018, 30(52), 1804982 10.1002/adma.201804982 High-Capacity Upconversion Wavelength and Lifetime Binary Encoding for Multiplexed Biodetection Lei Zhou+, Yong Fan+, Rui Wang, Xiaomin Li, Lingling Fan, and Fan Zhang* Angew. Chem. Int. Ed., 2018, 57(39), 12824-12829 10.1002/anie.201808209 Lifetime-engineered NIR-II Nanoparticles Unlock Multiplexed in Vivo Imaging Yong Fan, Peiyuan Wang, Yiqing Lu*, Rui Wang, Lei Zhou, Xianlin Zheng, Xiaomin Li, James A. Piper and Fan Zhang* Nat. Nanotechnol., 2018, 13(10), 941-946 10.1038/s41565-018-0221-0 NIR-II Nanoprobes In-vivo Assembly to Improve Image-guided Surgery for Metastatic Ovarian Cancer Peiyuan Wang, Yong Fan, Lingfei Lu, Lu Liu, Lingling Fan*, Mengyao Zhao, Yang Xie, Congjian Xu, and Fan Zhang* Nat. Commun., 2018, 9, 2898 10.1038/s41467-018-05113-8 Small-Molecule Lanthanide Complexes Probe for Second Near-Infrared Window Bioimaging Yanling Yang, Peiyuan Wang, Lingfei Lu, Yong Fan, Caixia Sun, Lingling Fan, Congjian Xu, Ahmed Mohamed El-Toni, Mansour Alhoshan, and Fan Zhang* Anal. Chem., 2018, 90(13), 7946-7952 10.1021/acs.analchem.8b00603 Er3+ Sensitized 1530 nm to 1180 nm Second Near-Infrared Window Upconversion Nanocrystals for in Vivo Biosensing Lu Liu, Shangfeng Wang, Baozhou Zhao, Peng Pei, Yong Fan, Xiaomin Li*, Fan Zhang* Angew. Chem. Int. Ed., 2018, 57(25), 7518-7522 10.1002/anie.201802889 Efficient 1064-nm NIR-II Excitation Fluorescent Molecular Dye for Deep-tissue High-resolution Dynamic Bioimaging Benhao Li+, Lingfei Lu+, Mengyao Zhao, Zuhai Lei, Fan Zhang* Angew. Chem. Int. Ed., 2018, 57(25), 7483-7487 10.1002/anie.201801226