王文宁 - 复旦大学 - 生物医学研究院

个人简介

工作经历教授，复旦大学，化学系，(2005.4-今) 访问学者，香港科技大学，生物化学系，(2002.2-2003.8) 副教授，复旦大学，化学系，(2000.12-2005.4) 讲师，复旦大学，化学系，(1996.4-2000.12) 博士后，日本国立分子科学研究所，(1995.12-1996.3) 教育经历博士，复旦大学，化学系，(1990-1995) 学士，复旦大学，化学系，(1986-1990) 所获人才项目曙光学者，上海市教委，2004 香港求槎基金会内地青年学者，香港求槎基金会，2003

研究领域

课题组主要运用结构生物学和计算生物学方法研究蛋白质的结构、动力学性质与生物功能的关系。我们主要关注的问题包括膜蛋白的大范围构像变化动力学，翻译后修饰对蛋白质构像的调节，信号传导通路中的蛋白－蛋白相互作用，以及内在无序蛋白的构象动力学与功能等。研究手段包括液体核磁共振，X-射线晶体衍射，单分子荧光能量共振转移，分子动力学模拟等计算生物学方法，及生物化学方法等。具体的研究方向包括：膜相关蛋白构像变化的动力学和调控；干细胞非对称分裂调控机制的研究；结合多种生物物理手段研究内在无序蛋白的结构、动力学和功能的关系。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Weng J., Wang W.* (2020) Dynamic Multivalent Interactions of Intrinsically Disordered Proteins. Curr. Opin. Struct. Biol. 62, 9-13. Wang D., Weng J.*, Wang W.*. (2019) Glycerol Transport through the Aquaglyceroporin GlpF: Bridging Dynamics and Kinetics with Atomic Simulation. Chem. Sci. 10, 6957-6965. Wu S., Wang D., Liu J., Feng Y., Weng J.*, Li Y., Gao X., Liu J.*, Wang, W.* (2017) The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins. Angew. Chemie. Int. Ed. 56, 7515-7519. (F1000 recommended) Feng Y., Zhang L., Wu S., Gao X., Liu J.*, Huang X.*, Wang W.* (2016) Multiple Metastable Conformations Co-exist in the Apo-Glutamine Binding Protein Structural Ensemble Revealed by Tightly Coupled Experimental and Computational Approaches. Angew. Chem. Int. Ed. 55, 13990-13994. Jia M., Shan Z., Yang Y., Liu C., Li J., Luo Z., Zhang M., Cai Y.*, Wen W.*, Wang W.* (2015) The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nat. Commun. 6, 8381. Pan Z, Zhu J, Shang Y, Wei Z, Jia M, Xia C, Wen W, Wang W.*, Zhang M* (2013) An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs. Structure, 21, 1007-1017. Jia M., Li J., Zhu J., Wen W., Zhang M*, Wang W.* (2012) Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gai subunits in G-coupled heterotrimeric proteins. J. Biol. Chem.287, 36766-36776. Zhu J., Wen W., Zheng Z., Shang Y., Wei Z., Xiao Z., Pan Z., Du Q.*, Wang W.*, Zhang M.* (2011) LGN/mInsc and LGN/NuMA complexes structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways. Mol. Cell, 43, 418-431. Wang W.*, Weng J., Zhang X., Liu M., Zhang M.* (2009) Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95 J. Am. Chem. Soc. 131, 787-796. Fu H., Liu Z., Li Z., Wang W.*, Fan K.* (2006) “Periodic density functional theory study of propane oxidative dehydrogenation over V2O5(001) surface”, J. Am. Chem. Soc. 128, 11114-11123.