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个人简介

2012.1 – 现在 复旦大学化学系 教授 2010年 聘为博士生导师 2002.12 – 2012.1 复旦大学化学系 副教授 1997.7 − 2002.12 复旦大学化学系 讲师 1992.9 − 1997.7 复旦大学化学系 助教 2000年9月至2003年6月 复旦大学获得博士学位 1994年9月至1997年6月 复旦大学获得硕士学位 1988年9月至1992年6月 复旦大学获得学士学位

研究领域

(1)分子靶向抗癌新药的研发;新药关键中间体的工艺研发;新药多晶型的研发。(2)递药新材料以及新型多孔诊疗一体化材料的研发。

近期论文

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Mesoporous carbon hemispheres integrated with Fe–Gd nanoparticles for potential MR/PA imaging-guided photothermal therapy , Mengmeng Zhang, Tianze Wu, Hui Zhang, Zhenxia Chen, Yannan Yang, Yun Ling * and Yaming Zhou,* Journal of Materials Chemistry B, 2023, ASAP Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach , Tianze Wu, Yi Chen, Chengbin Yang, Mingzhu Lu, Fang Geng, Jianhua Guo, Yan Pi, Yun Ling, Jun Xu, Tong Cai, Lei Lu & Yaming Zhou,* Cardiovascular Toxicology, 2023, ASAP Discovery and identification of a novel PI3K inhibitor with enhanced CDK2 inhibition for the treatment of triple negative breast cancer , Chengbin Yang, Menghui Wang, Yimin Gong, Mingli Deng, Yun Ling, Qingquan Li, Jianxin Wang*, Yaming Zhou,* Bioorganic Chemistry, 2023, 140, 106779 Discovery of a photosensitizing PI3K inhibitor for tumor therapy: Design, synthesis and in vitro biological evaluation , Chengbin Yang, Yimin Gong, Mingli Deng, Yun Ling, Jianxin Wang*, Yaming Zhou,* Bioorganic & Medicinal Chemistry Letters, 2023,94, 129459 Reticular chemistry of the fcu-type Gd(III)-doped metal-organic framework for T1-weighted magnetic resonance imaging,Tianze Qiu; Tianze Wu; Mingzhu Lu; Yuxi Xie; Mengmeng Zhang; Dan Luo; Zhenxia Chen; Bo Yin; Yaming Zhou; Yun Ling,* Small, 2023, 2303063 Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia , Chengbin Yang, Yi Chen, Tianze Wu, Yunjian Gao, Xiaofeng Liu, Yongtai Yang, Yun Ling, Yu Jia, Mingli Deng*, Jianxin Wang, Yaming Zhou,* European Journal of Medicinal Chemistry, 2023, 258, 115543 Nanosheets of two-dimensional photoluminescent Lanthanide phosphonocarboxylate frameworks decorated with free carboxylic groups for latent fingerprint imaging , Dan Luo, Hongjie He, Huiru Jing, Yun Ling, Yu Jia, Yongtai Yang, Xiaofeng Liu, Zhenxia Chen* and Mingli Deng* Dalton Transcations, 2023, 52, 9208-9214;>> Fulltext link Gelothermal Synthesis of Monodisperse MIL-88A Nanoparticles with Tunable Sizes and Metal Centers for Potential Bioapplications , Mengmeng Zhang, Mingzhu Lu, Tianze Qiu, Qiao Wang, Zhenxia Chen, Mingli Deng, Yongtai Yang, Yannan Yang, Wei Li, Yun Ling,* and Yaming Zhou Small, 2023, 19(34), 2301894 Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171 , Ruiqing Xiang, Mingzhu Lu, Tianze Wu, Chengbin Yang, Yu Jia, Xiaofeng Liu, Mingli Deng,**, Yu Ge, Jun Xu, Tong Cai, Yun Ling, Yaming Zhou,* European Journal of Medicinal Chemistry, 2023, 223, 257, 115514 Design, synthesis and in vitro biological evaluation of 2-aminopyridine derivatives as novel PI3Kδ inhibitors for hematological cancer, Chengbin Yang, Yimin Gong, Yunjian Gao, Mingli Deng, Xiaofeng Liu, Yongtai Yang, Yun Ling, Yu Jia*, Yaming Zhou*; Bioorg. Med. Chem. Lett., 2023, 82, 129152>> Fulltext link Gadolinium-based contrast agents built of DO3A-pyridine scaffold: Precisely tuning carboxylate group for enhanced magnetic resonance imaging, Yongyin Geng, TianzeWu, Qiuyue Han, Yongtai Yang, Zhenxia Chen, Xuanxuan Li, Bo Yin, Yaming Zhou, Yun Ling*; Chinese Chemical Letters, 2023, 34, 107685>> Fulltext link A Pyridinesulfonamide Derivative FD268 Suppresses Cell Proliferation and Induces Apoptosis via Inhibiting PI3K Pathway in Acute Myeloid Leukemia, Yi Chen, Tianze Wu, Chengbin Yang, Mingzhu Lu, Zhenxia Chen, Mingli Deng, Yu Jia, Yongtai Yang, Xiaofeng Liu, Hongyan Wang, Yun Ling,, Lei Lu,* Yaming Zhou*; PLoS ONE, 2022, 17(11):e0277893>> Fulltext link Hybrid Nanomaterials for Cancer Immunotherapy, Jianing Li, Wanyue Lu, Yannan Yang*, Ruiqing Xiang, Yun Ling, Chengzhong Yu*, Yaming Zhou*; Advanced Science, 2022, 2204932>> Fulltext link Physical and Chemical Cues at the Nano–Bio Interface for Immunomodulation, Feng-Yuan Wang, Tianze Qiu, Yun Ling, Yannan Yang,* and Yaming Zhou*; Angew. Chem. Int. Ed. , 2022, 61, e202209499>> Fulltext link Unprecedented Ferromagnetic Exchange Coupling of a Square-Planar Cu4O unit in a scu-Type Porous Metal–Organic Framework and Its Reticular Chemistry, Tianze Qiu, Yongchen Wang, Yihan Li, Lin Zhu*, Zhenxia Chen, Yu Jia, Pu Zhao, Wei Shi, Yaming Zhou, and Yun Ling*; Cryst. Growth Des., 2022, 22, 7, 4005–4011>> Fulltext link Hollow carbon nanospheres embedded with stoichiometric γ-Fe2O3 and GdPO4: tuning the nanospheres for in vitro and in vivo size effect evaluation, Hui Zhang, Jianping Zhang, Yi Chen, Tianze Wu, Mingzhu Lu, Zhenxia Chen, Yu Jia, Yongtai Yang, Yun Ling* and Yaming Zhou*; Nanoscale Advances, 2022, 4, 1414 Development of Anti-Breast Cancer PI3K Inhibitors Based on 7-Azaindole Derivatives through Scaffold Hopping: Design, Synthesis and in Vitro Biological Evaluation, Chengbin Yang, Mingzhu Lu, Yi Chen, Ruiqing Xiang, Tianze Qiu, Yu Jia, Yongtai Yang, Xiaofeng Liu, Mingli Deng, Yun Ling, Yaming Zhou*; Bioorganic Chemistry, 2021, 117, 105405 Ultrafine Fe-modulated Ni nanoparticles embedded within nitrogen-doped carbon from Zr-MOFs-confined conversion for efficient oxygen evolution reaction, Lingtao Kong, Zhouxun Li, Hui Zhang, Mengmeng Zhang, Jiaxing Zhu, Mingli Deng*, Zhenxia Chen, Yun Ling & Yaming Zhou, Frontiers of Chemical Science and Engineering, 2022, 16, 1114–1124 Effect of Fluorination on the Crystal Structure, Stability and Gas Adsorption Property in Zinc(II) Metal-organic Frameworks, Xin Zhang, Zhenxia Chen, Yongtai Yang, Mingli Deng*, Linhong Weng; Chinese Journal of Structrual Chemistry, 2022, 41(2), 49-56 Post-synthetic anchoring Fe(III) into a fcu-type Zr-MOF for the catalyzed hydrolysis of 5-hydroxylmethoxyfurfural, Mengmeng Zhang, Jiaying Lou, Rui Xu, Peng Li, Yunfei Sha, Hui Zhang, Yu Jia, Zhenxia Chen, Da Wu*, Yun Ling*, YamingZhou; Microporous Mesoporous Materials, 2021, 328, 111449 Reticular Chemistry Approach to Explore the Catalytic CO2-epoxide Cycloaddition Reaction over Tetrahedral Coordination Lewis Acidic Sites in a Rutile-type Zinc-phosphonocarboxylate Framework, Lingtao Kong, Zhouxun Li, Han Hu, Jiaxing Zhu, Zhenxia Chen*, Mingli Deng*, Yun Ling, Peng Li, Yu Jia, Yaming Zhou; Chemical Engineering Journal, 2022, 427,131759 Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity, Chengze Tian, Chengbin Yang, Tianze Wu, Mingzhu Lu, Yi Chen, Yongtai Yang, Xiaofeng Liu, Yun Ling, Mingli Deng, Yu Jia*, Yaming Zhou* Bioorganic & Medicinal Chemistry Letters, 2021, 48, 128271 Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation, Chengbin Yang, Chenyue Xu, Zhipeng Li, Yi Chen, Tianze Wu, Hui Hong, Mingzhu Lu, Yu Jia, Yongtai Yang, Xiaofeng Liu, Mingli Deng, Zhenxia Chen, Qingquan Li*, Yun Ling*, Yaming Zhou* European Journal of Medicinal Chemistry, 2021, 223, 1136613 Hollow carbon nanospheres dotted with Gd–Fe nanoparticles for magnetic resonance and photoacoustic imaging, Hui Zhang, Tianze Wu, Yi Chen, Qianqian Zhang, Zhenxia Chen, Yun Ling,* Yu Jia, Yongtai Yang, Xiaofeng Liu and Yaming Zhou* Nanaoscale, 2021, 13, 10943-10952 Multimetal lanthanide phosphonocarboxylate frameworks: structure, colour tuning and near-infrared emission, Huiru Jing, Wenyan Dan, Jiaxing Zhu, Yun Ling, Yu Jia, Yongtai Yang, Xiaofeng Liu, Zhenxia Chen* and Yaming Zhou* Dalton Transcations, 2021, 50, 7380 - 7387 TEA-assistant synthesis of MOF-74 nanorods for drug delivery and in-vitro magnetic resonance imaging, Jiaqi Hu, Yi Chen, Hui Zhang, Zhenxia Chen*, Yun Ling, Yongtai Yang, Xiaofeng Liu, Yu Jia, Yaming ZhouMicroporous Mesoporous Materials, 2021, 315, 110900 Controlled syntheses of Mg-MOF-74 nanorods for Drug Delivery, Jiaqi Hu; Yi Chen; Hui Zhang; Zhenxia Chen*, Journal of Solid State Chemistry, 2021, 294, 121853 Precise regulating synergistic effect in metal–organic framework for stepwise-controlled adsorption, Jiaxing Zhu, Yi Yu, Hongchuan Fan, Huaqiang Cai,* Zhenxia Chen, Linhong Weng, Yun Ling* and Yaming Zhou, Inorganic Chemistry Frontier, 2021, 8, 1666-1674 In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery, Hui Zhang; Jianping Zhang; Qianqian Zhang; Xiaofeng Liu; Yongtai Yang; Yun Ling; Yaming Zhou*, Nanoscale Advances, 2020,2, 5296-5304 Coordination and space confined preparation of nickel sub-nanoparticles within a metal-organic framework for catalytic degradation of methyl orange, Zhouxun Li, Hui Zhang, Lingtao Kong, Zhenxia Chen*, Yongtai Yang, Xiaofeng Liu, Mingli Deng*, Yaming Zhou, Journal of Environmental Chemical Engineering, 2020,8(5),104363 Cobalt substitution in a flexible metal-organic framework: modulating a soft paddle-wheel unit for tunable gate-opening adsorption, Jiaxing Zhu; Junye Chen; Tianze Qiu; Mingli Deng*; Qingshu Zheng; Zhenxia Chen; Yun Ling*; Yaming Zhou, Dalton Transactions, 2019,48(21), 7100-7104 A robust etb-type metal-organic framework showing polarity-exclusive adsorption of acetone over methanol for their azeotropic mixture, Han Hu; Jiaxing Zhu; Feilong Yang; Zhenxia Chen; Mingli Deng; Linhong Weng; Yun Ling*; Yaming Zhou, Chemical Communications, 2019,55(46), 6495-6498

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