谭相石 - 复旦大学

个人简介

2007年09月至今复旦大学化学系/生物医学研究院，教授，博士生导师 2000年04月至2007年08月美国Texas A & M University, Research Scientist 1998年03月至2000年03月日本学术振兴会特别研究员 1997年10月至1998年03月英国皇家学会特别研究员 1996年11月至1997年10月法国CEA-Grenoble博士后 1993年09月至1996年07月南京大学获得博士学位

研究领域

生物无机化学和化学生物学生理与病理过程中关键金属蛋白、金属酶的结构、功能及其作用分子机制功能金属蛋白质的设计和结构与功能的关系研究金属离子在细胞内转运、代谢、及其稳态平衡调控的分子机制可溶性鸟苷酸环化酶介导NO/CO信号转导的结构基础和分子机制研究老年痴呆症中金属离子稳态失衡与调控的分子机制研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jie Pan, Qiming Xu, Ying-Wu Lin, Fangfang Zhong and Xiangshi Tan*, Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase，Chem. Commun., 49, 7454-7456，2013. Xiaoping Lv, Wei Li, Ying Luo, Dandan Wang, Cuiqing Zhu, Zhong-Xian Huang and Xiangshi Tan*, Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity，Chem. Commun., 49, 5865-5867，2013. Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zhen Wang, Yang Tian, Zhong-Xian Huang and Xaingshi Tan*, Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase, Chem. Commun., 49, 1452-145, 2013. Wei Li, Hongfei Wang, Zheng Chen, Qing Ye, Yang Tian, Xin Xu, Zhong-xian Huang, Pingwei Li, Xiangshi Tan*, Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile, Chem. Commun., 50, 584-586, 2014. Ying Luo, Yuxia Xu, Qingui Bao, Zhichhun Ding, Cuiqing Zhu, Zhong-Xian Huang, Xiangshi Tan*, The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of A1–42 with Cu ions, J Biol Inorg Chem, 18(1):39-47, 2013. Yi Liu, Xiaofei Zhu, Feng Wang, Pingwei Li, Zhong-xian Huang and Xiangshi Tan*, Probing the role of the bridging C509 between the [Fe4S4] cubane and [NipNid] centre in the A-Cluster of Acetyl-Coenzyme A Synthase, Chem. Commun., 47(4), 1291-1293, 2011. Yi Liu, Feng Wang, Pingwei Li, and Xiangshi Tan*, Insights into the Mechanistic Role of the [Fe4S4] Cubane in the A-Cluster {[Fe4S4]-(SR)-[NipNid]} of Acetyl-Coenzyme A Synthase, ChemBioChem., 12(9):1417-1421, 2011. Xiangshi Tan, Marlene Martinho, Audria Stubna, Paul A. Lindahl, Eckard Münk, Mössbauer Evidence for an Exchange-Coupled {[Fe4S4]1+:Nip1+} A-cluster in Isolated Alpha Subunits of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase, J. Am. Chem. Soc. , 130, 6712-6713, 2008. Xiangshi Tan, Ivan V. Surovtsev, and Paul A. Lindahl, Kinetics of CO Insertion and Acetyl Group Transfer Steps, and a Model of the Acetyl-CoA Synthase Catalytic Mechanism, J. Am. Chem. Soc. 128(37), 12331-12338, 2006. Xiangshi Tan, Huay-Keng Loke, Shawn Fitch and Paul A. Lindahl, The Tunnel of the Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase Regulates Delivery of CO to the Active Site, J. Am. Chem. Soc. 127, 5833-5836, 2006.