刘宝红 - 复旦大学 - 生物医学研究院

个人简介

工作经历教授复旦大学，生物医学研究院，化学系 (2005年-至今) 副教授复旦大学，化学系，生物医学研究院 (2000年-2005年) 讲师复旦大学，化学系 (1997年-2000年) 邀请访问教授巴黎高科 (2013/09-2013/10) 邀请访问教授瑞士洛桑高工（2006/10-2006/12）邀请访问教授佩皮尼昂大学（2006/9-2006/10）邀请访问教授巴黎高科（2005/01-2005/02）教育经历博士复旦大学，化学系 (1994-1997) 硕士复旦大学，化学系 (1991-1994) 学士复旦大学，化学系 (1987-1991) 所获人才项目国家杰出青年科学基金国家自然科学基金2009 上海市优秀学术带头人上海市科委2009 曙光学者上海市教委2006 上海市启明星及跟踪上海市科委2000 所获奖项所获奖项获奖名称授予单位时间自然科学三等奖（第三完成人）教育部2014 自然科学一等奖（第三完成人）教育部2006 科技进步三等奖（第三完成人）教育部1999

研究领域

课题组在生物分析化学、微/纳分析系统、生物传感器及蛋白质分析新方法和新技术等方面进行了深入系统的研究，提出了基于结构性能可控的新型纳米材料组装功能化界面，发展生物传感新技术，旨在建立快速检测与疾病相关的重要标志物以及蛋白质相互作用的分析方法。提出了微/纳通道表面修饰的新方法，构建仿生界面和特异性生物识别分子层，成功地用于蛋白质的在线酶解和相互作用研究。研发了多种蛋白质酶解新技术，开发的微/纳反应器为低丰度蛋白质的分析鉴定提供了新的技术平台。提出了基于光电化学原理的离子源内氧化还原反应概念，发展了电化学调控-激光解析离子化反应新技术，进行蛋白质的结构分析、高效鉴定和反应机理研究。课题组长刘宝红主持和参与多项国家和省部级项目，包括国家重点研发计划（项目首席）、国家自然科学基金项目、上海市科委重点项目等。迄今为止，已在Anal. Chem., ACS Nano, Angew. Chem. Inter. Ed., Chem. Eur. J., Small, Lab Chip 等国内外学术刊物上发表论文近200篇，被引用5000多次。

近期论文

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Fang Xiaoni, Duan Yaokai, Liu Yujie, Adkins G, Zang Weijun, Zhong Wenwan, Qiao Liang,* Liu Baohong* (2017) Photochemical bionanoreactor for efficient visible-light-driven in vitro drug metabolism. Analytical Chemistry 89, 7365 Du Ruijun，Zhu Lina，Gan Jinrui，Wang Yuning，Qiao Liang*，Liu Baohong* (2016) Ultrasensitive Detection of Low-Abundance Protein Biomarkers by Mass Spectrometry Signal Amplification Assay，Analytical Chemistry 88, 6767 Fang Xiaoni，Zhao Jingjing，Zhang Kun，Yang Pengyuan，Qiao Liang*，Liu, Baohong* (2016) Polydopamine Grafted Porous Graphene as Biocompatible Nanoreactor for Efficient Identification of Membrane Proteins，ACS Applied Materials & Interfaces 8, 6363 Zhao, Jingjing，Zhang, Kun，Li, Yixin，Ji, Ji，Liu Baohong* (2016) High-Resolution and Universal Visualization of Latent Fingerprints Based on Aptamer- Functionalized Core-Shell Nanoparticles with Embedded SERS Reporters，ACS Applied Materials and Interfaces 8, 14389 Fang, Xiaoni，Qiao, Liang，Yan, Guoquan，Yang, Pengyuan，Liu, Baohong* (2015) Multifunctional Nanoreactor for Comprehensive Characterization of Membrane Proteins Based on Surface Functionalized Mesoporous Foams，Analytical Chemistry 87, 9360 Zhang, Kun，Zhao, Jingjing，Ji, Ji，Li, Yixin，Liu Baohong* (2015) Quantitative Label-Free and Real-Time Surface-Enhanced Raman Scattering Monitoring of Reaction Kinetics Using Self-Assembled Bifunctional Nanoparticle Arrays，Analytical Chemistry 87, 8702 Gan, Jinrui，Wei, Xiang，Li, Yixin，Wu, Jiao，Qian, Kun*，Liu, Baohong* (2015) Designer SiO2@Au nanoshells towards sensitive and selective detection of small molecules in laser desorption ionization mass spectrometry，Nanomedicine: Nanotechnology, Biology and Medicine 11, 1715 Xu, Huiying，Xiao, Jingjing，Liu Baohong*，Griveau, Sophie，Bedioui, Fethi (2015) Enhanced electrochemical sensing of thiols based on cobalt phthalocyanine immobilized on nitrogen-doped graphene，Biosensors and Bioelectronics 66, 438 Xu, Huiying，Geng, Fenghua，Wang, Yongxiang，Xu, Maotian，Lai, Xinhe*，Qu, Peng，Zhang, Yintang，Liu, Baohong* (2015) A label-free fluorescent molecular switch for a DNA hybridization assay utilizing a G-quadruplex-selective auramine O，Chemical Communications 51, 8622 Liao, Lei，Wang, Sinong，Xiao, Jingjing，Bian, Xiaojun，Zhang, Yahong，Scanlon, Micheal D，Hu, Xile，Tang, Yi*，Liu Baohong*，Girault, Hubert H. (2014) A nanoporous molybdenum carbide nanowire as an electrocatalyst for hydrogen evolution reaction，Energy & Environmental Science 7, 387 Zhang, Kun，Ji, Ji，Li, Yixin，Liu Baohong* (2014) Interfacial Self-Assembled Functional Nanoparticle Array: A Facile Surface-Enhanced Raman Scattering Sensor for Specific Detection of Trace Analytes，Analytical Chemistry 86, 6660 Fang, Xiaoni，Zhang, Peng，Qiao, Liang，Feng, Xiaoyan，Zhang, Xiangmin，Girault, Hubert H.，Liu, Baohong* (2014) fficient Drug Metabolism Strategy Based on Microsome - Mesoporous Organosilica Nanoreactors，Analytical Chemistry 86, 10870 Ji, Ji，Nie, Lei，Li, Yixin，Yang, Pengyuan*，Liu Baohong* (2013) Simultaneous Online Enrichment and Identification of Trace Species Based on Microfluidic Droplets，Analytical Chemistry 85, 9617 Liao, Lei，Zhu, Jie，Bian, Xiaojun，Zhu, Lina，Scanlon, Micheal D.，Girault, Hubert H.，Liu, Baohong*(2013) MoS2 Formed on Mesoporous Graphene as a Highly Active Catalyst for Hydrogen Evolution，Advanced Functional Materials 23, 5326 Qian K, Wan JJ, Liu F, Girault HH, Liu BH*, Yu CZ*. (2009) A phospho-directed macroporous alumina-silica nanoreactor with multi-functions. ACS Nano. 3, 3656 Qiao L, Roussel C, Wan JJ, Kong JL, Yang PY, Girault HH, Liu BH*.(2008) MALDI in-source photooxidation reactions for online peptide tagging. Angewandte Chemie International Edition 47, 2646