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研究领域

纳米光学生物传感; 分子发光; 现代分离分析 i)局域表面等离子共振(LSPR); ii)表面增强拉曼光谱(SERS); iii)表面增强电化学发光(SEECL); iv)纳米光学分离分析。

近期论文

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2013: Longhua Guo, Yang Xu, Abdul Rahim Ferhan, Guonan Chen, and Dong-Hwan Kim. Oriented gold nanoparticle aggregation for colorimetric sensors with surprisingly high analytical figures of merit. Journal of American Chemical Society, 2013, 135(33), 12338-12345. Yang Xu, Longhua Guo,* Lianzhu Huang, Kannan Palanisamy, Donghwan Kim and Guonan Chen. Facile preparation of partially functionalized gold nanoparticles via a surfactant-assisted solid-phase approach. Journal of Colloid & Interface Science, 2013, 409, 32–37. Rong Huang, Daifang Wang, Shuzhen Liu, Longhua Guo*, Fangfang Wang, Zhenyu Lin, Bin Qiu, Guonan Chen. Preparative separation of enantiomers based on functional nucleic acids modified gold nanoparticles. Chariality, ASAP. DOI: 10.1002/chir.22208. Longhua Guo, Abdul Rahim Ferhan, Hailan Chen, Changming Li, Guonan Chen, Seungpyo Hong, Dong-Hwan Kim. Distance-mediated plasmonic dimers for reusable colorimetric switches: a measurable peak shift of over 60 nm. Small, 2013, 9, 2, 234–240. Selected as a Frontispiece. Longhua Guo,* Daifang Wang, Yang Xu, Bin Qiu, Zhenyu Lin, Hong Dai, Huang-Hao Yang and Guonan Chen.* Discrimination of enantiomers based on LSPR biosensors fabricated with weak enantioselective and nonselective receptors. Biosensors and Bioelectronics, 2013, 47,199-205. Rong Huang, Wenming Xiong, Daifang Wang, Longhua Guo*, Zhenyu Lin, Lishuang Yu, Kedan Chu, Bin Qiu, Guonan Chen.* Label-free aptamer-based partial filling technique for enantioseparation and determination of dl-tryptophan with micellar electrokinetic chromatography. Electrophoresis. 2013, 34(2), 254-259. Suyan Qiu, Miao Miao, Tianxi Wang, Zhenyu Lin, Longhua Guo, Bin Qiu, Guonan Chen. A fluorescent probe for detection of histidine in cellular homogenate and ovalbumin based on the strategy of click chemistry. Biosens Bioelectron. 2013, 42, 332-336. Suyan Qiu, Xianghui Li, Wenming Xiong, Lidan Xie, Longhua Guo, Zhenyu Lin, Bin Qiu, Guonan Chen. A novel fluorescent sensor for mutational p53 DNA sequence detection based on click chemistry. Biosensors and Bioelectronics, 2013, 41, 403-408. Xiaofeng Wei, Lingyan Zheng, Fang Luo, Zhenyu Lin*, Longhua Guo, Bin Qiu and Guonan Chen*. Fluorescence biosensor for the H5N1 antibody based on a metal–organic framework platform. J. Mater. Chem. B, 2013, 1, 1812-1817. Xi Zhu, Hanye Zheng, Xiaofeng Wei, Zhenyu Lin, Longhua Guo, Bin Qiu and Guonan Chen. Metal–organic framework (MOF): a novel sensing platform for biomolecules. Chem. Commun., 2013,49, 1276-1278. Lidan Xie, Hanye Zheng, Wenmei Ye, Suyan Qiu, Zhenyu Lin, Longhua Guo, Bin Qiu and Guonan Chen. Novel colorimetric molecular switch based on copper(I)-catalyzed azide–alkyne cycloaddition reaction and its application for flumioxazin detection. Analyst, 2013,138, 688-692. Huifeng Xu, Hongzhi Ye, Xi Zhu, Shijing Liang, Longhua Guo, Zhenyu Lin, Xianxiang Liu and Guonan Chen. Dual-channel cathodic electrochemiluminescence of luminol induced by injection of hot electrons on a niobate semiconductor modified electrode. Analyst, 2013,138, 234-239. Xiaojuan Li, Lingyan Zheng, Lianzhu Huang, Ou Zheng, Zhenyu Lin, Longhua Guo, Bin Qiu, Guonan Chen. Adsorption removal of crystal violet from aqueous solution using a metal-organic frameworks material, copper coordination polymer with dithiooxamide. Journal of Applied Polymer Science. 2013, DOI: 10.1002/app.39009. Longhua Guo*, Yuechun Yin, Rong Huang, Bin Qiu, Zhenyu Lin, Huang-Hao Yang, Jianrong Li, Guonan Chen. Enantioselective analysis of melagatran via a LSPR biosensor integrated with microfluidic chip. Lab on a Chip, 2012, 12(20), 3901-3906. (This article was collected in "Lab on a Chip Top 10%") Longhua Guo, Dong-Hwan Kim. LSPR biomolecular assay with high sensitivity induced by aptamer-antigen-antibody sandwich complex. Biosensors and Bioelectronics, 2012, 31 (1), 567-570. Xiaofeng Wei, Wenlie Lin, Na Ma, Fang Luo, Zhenyu Lin , Longhua Guo, Bin Qiu and Guonan Chen. Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA. Chem. Commun., 2012, 48, 6184-6186. Guiyun Zhang, Wenlie Lin, Weiqiang Yang, Zhenyu Lin, Longhua Guo, Bin Qiu and Guonan Chen. Logic gates for multiplexed analysis of Hg2+ and Ag+. Analyst, 2012, 137, 2687-2691. Zhenyu Lin, Sen Gao, Jing Lin, Wenlie Lin, Suyan Qiu, Longhua Guo, Bin Qiu and Guonan Chen. Visual detection of copper(II) based on the aggregation of gold nano-particles via click chemistry. Anal. Methods, 2012, 4, 612-615. Qihong Cai, Chunmei Wang, Jin Zhou, Fang Luo, Zhenyu Lin, Longhua Guo, Bin Qiu and Guonan Chen. Terminal protection G-quadruplex-based turn-on fluorescence biosensor for H5N1 antibody. Anal. Methods, 2012,4, 3425-3428. Hong Dai, Yanling Chen, Yanyu Lin, Guifang Xu, Caiping Yang, Yuejin Tong, Longhua Guo, Guonan Chen. A new metal electrocatalysts supported matrix: Palladium nanoparticles supported silicon carbide nanoparticles and its application for alcohol electrooxidation. Electrochimica Acta, 2012, 85, 644-649. Longhua Guo, Youju Huang, Yoshikuni Kikutani, Yo Tanaka, Takehiko Kitamori, Dong-Hwan Kim. In situ assembly, regeneration and plasmonic immunosensing of a Au nanorod monolayer in a closed-surface flow channel. Lab on a Chip, 2011, 11,3299-3304. Longhua Guo, Abdul Rahim Ferhan, Kijoon Lee and Dong-Hwan Kim. Nanoarray-based Biomolecular Detection Using Individual Au-Nanoparticles with Minimized LSPR Variations. Analytical Chemistry, 2011, 83 (7), 2605–2612. Longhua Guo, Dong-Hwan Kim. Reusable plasmonic aptasensor: Using a single nanoparticle to establish a calibration curve and to detect analytes. Chemical Communications, 2011, 47 (25), 7125 - 7127. Longhua Guo, Xiaodong Zhou, Dong-Hwan Kim. Facile fabrication of distance-tunable Au-nanorod chips for single-nanoparticle plasmonic biosensors. Biosensors and Bioelectronics, 2011, 26, 2246–2251. Longhua Guo, FengFu Fu and Guonan Chen. Capillary electrophoresis with electrochemiluminescence detection: fundamental theory, apparatus, and applications. Analytical and Bioanalytical Chemistry, 2011, 399, 3323-3343. Bin Qiu, Lingling Xue, Yanping Wu, Zhenyu Lin, Longhua Guo*, Guonan Chen. Mechanism study on inorganic oxidants induced inhibition of Ru(bpy)32+ electrochemiluminescence and its application for sensitive determination of some inorganic oxidants, Talanta, 2011, 85,339-344. Bin Qiu, Longhua Guo, Chunhua Guo, Zhiyong Guo, Zhenyu Lin, and Guonan Chen. Synthesis of a new Ni-phenanthroline complex and its application as an electrochemical probe for detection of nucleic acid. Biosensors and Bioelectronics, 2011, 26, 2270-2274. Bin Qiu, Longhua Guo, Mingluan Chen, Zhenyu Lin and Guonan Chen. Study on interaction between a new fluorescent probe 2-methylbenzo[b][1,10]phenanthrolin -7(12H)-one and BSA. Analyst, 2011, 136, 973-978. Hailan Chen, Longhua Guo, AR Ferhan, Dong-Hwan Kim. Multilayered Polypyrrole-Coated Carbon Nanotubes to Improve Functional Stability and Electrical Properties of Neural Electrodes. Journal of Physical Chemistry C, 2011, 115, 5492-5499. Bin Qiu, Xiaofen Jiang, Longhua Guo, Zhenyu Lin, Zongwei Cai, Guonan Chen. A highly sensitive method for detection of protein based on inhibition of Ru(bpy)32+/TPrA electrochemiluminescent system. Electrochimica Acta, 2011, 56 (20), 6962-6965. Peng Si, Palanisamy Kannan, Longhua Guo, Hungsun Son and Dong-Hwan Kim. Highly stable and sensitive glucose biosensor based on covalently assembled high density Au nanostructures. Biosensors and Bioelectronics, 2011, 26, 3845-3851. Hailan Chen, Jianmin Shen, Longhua Guo, Yuan Chen, Dong-Hwan Kim. Cellular response of RAW 264.7 to spray-coated multi-walled carbon nanotube films with various surfactants. Journal of Biomedical Materials Research Part A, 2011, 96A (2), 413–421. Hailan Chen, Kannan Palanisamy, Longhua Guo, Hongyu Chen and Dong-Hwan Kim. Direct growth of highly branched single crystal Au nanostructures on electrode surface: Their surface enhanced Raman scattering and electrocatalytic applications. Journal of Materials Chemistry, 2011, 21 (45), 18271-18278.

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