高瑜 - 福州大学 - 化学学院

研究领域

抗肿瘤转移纳米药物输送系统主要从事创新药物制剂的研究，以提高药物的有效性、降低毒副作用。主要学术成绩涵盖药物新材料、新技术和新工艺的应用基础研究：（1）成功构建多种新型靶向纳米载药系统改善难溶性药物的功效，降低毒副作用；（2）设计并合成出一系列新型基因非病毒载体显著提高基因药物转染效率；（3）构建多种纳米载药系统用于改善临床肿瘤治疗效果并进行详细机制研究；（4）设计构建可特异性调控循环肿瘤细胞用于预防肿瘤转移的纳米药物。

近期论文

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Yu Gao, Ye Ding, Haiying Chen, Haijun Chen* and Jia Zhou*. Targeting krüppel-like factor 5 (KLF5) for cancer therapy. Current Topics in Medicinal Chemistry. DOI: 10.2174/1568026615666150302105052 (IF = 3.453) Yu Gao*, Zhihong Li, Chaoqun Wang, Jiali You, Biyu Jin, Fan Mo, Jianzhong Chen, Yunquan Zheng, Haijun Chen*. Self-assembled chitosan/rose bengal derivative nanoparticles for targeted sonodynamic therapy: preparation and tumor accumulation. RSC Advances, 5 (2015) 17915 - 17923 (IF = 3.708) Yu Gao*, Zhihong Li, Xiaodong Xie, Chaoqun Wang, Jiali You, Fan Mo, Biyu Jin, Jianzhong Chen, Jingwei Shao, Haijun Chen, Lee Jia*. Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: synthesis and biological evaluation. Eur. J. Pharm. Sci. 70 (2015) 55-63 (IF = 3.005) Haijun Chen#, Yu Gao# (co-first author), Ailan Wang, Xiaobin Zhou, Yunquan Zheng, Jia Zhou*. Evolution in Medicinal Chemistry of Ursolic Acid Derivatives as Anticancer Agents. Eur. J. Med. Chem. 92 (2015) 648-655 (IF = 3.432) Jingjing Xie, Yusheng Lu, Haiyan Dong, Rongli Zhao, Hongning Chen, Weiyu Shen, Patrick J. Sinko, Yewei Zhu, Jichuang Wang, Jingwei Shao*, Yu Gao, Fangwei Xie, and Lee Jia*. Enhanced Specifi city in Capturing and Restraining Circulating Tumor Cells with Dual Antibody–Dendrimer Conjugates. Adv. Funct. Mater. 25 (2015) 1304–1313. (IF = 10.439) Suhong Yu, Xingtian Yang, Yewei Zhu, Fangwei Xie, Yusheng Lu, Ting Yu, Cuicui Yan, Jingwei Shao, Yu Gao, Fan Mo, Guoneng Cai, Patrick J. Sinko, Lee Jia*. Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex. Sci. Rep. 5 (2015) 7830. (IF = 5.078) Haiyan Dong, Xiang Yang, Jingjing Xie, Liping Xiang, Yuanfang Li, Minrui Ou, Ting Chi, Zhenhua Liu, Suhong Yu, Yu Gao, Jianzhong Chen, Jingwei Shao, Lee Jia. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochemical Pharmacology 93 (2015) 151–162. (IF = 4.650) Rong-Jie Zeng, Yu Li, Jian-Zhong Chen*, Gui-Xin Chou*, Yu Gao, Jing-Wei Shao, Lee Jia, Sheng-Dong Wu, Shui-Sheng Wu. A novel UPLC-MS/MS method for sensitive quantitation of boldine in plasma, a potential anti-inflammatory agent: application to a pharmacokinetic study in rats. Biomedical Chromatography 29 (2015) 459–464 (IF = 1.662) Haijun Chen, Xiaobin Zhou, Ailan Wang, Yunquan Zheng, Yu Gao, Jia Zhou*. Evolutions in Fragment-Based Drug Design: Deconstruction-Reconstruction Approach. Drug Discovery Today 1 (2015) 105-113. (IF = 5.964) Yu Gao, Jingjing Xie, Haijun Chen, Songen Gu, Rongli Zhao, Jingwei Shao, Lee Jia*. Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnology Advances 32(2014)761-777. (IF = 8.905) Yu Gao, Jingwei Shao, Zhou Jiang, Songen Gu, Suhong Yu, Ke Zheng, Lee Jia*. Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discovery Today 19(2014)326-340. (IF = 5.964) Haijun Chen1, Yu Gao1 (co-first author), Jianlei Wu, Yingyu Chen, Buyuan Chen, Jianda Hub*, Jia Zhou*. Exploring Therapeutic Potentials of Baicalin and Its Aglycone Baicalein for Hematological Malignancies. Cancer Letters. 354(2014):5-11. (IF = 5.016) Haijun Chen*, Guihua He, Cailong Li, Longrong Dong, Xiaobo Xie, Yu Gao, Jia Zhou*. Development of a Concise Synthetic Approach to Access Oroxin A. RSC Advances. 4 (2014) 45151-45154. (IF = 3.708) Jianzhong Chen, Jichuang Wang, Jingwei Shao, Yu Gao, Jianguo Xu, Suhong Yu, Zhenhua Liu, Lee Jia*. The unique pharmacological characteristics of Mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis. Medicinal Research Reviews, 34 (2014) 979-1000 (IF = 8.131) Haijun Chen*, Xiaobin Zhou, Yu Gao, Biyuan Zheng, Fengxiang Tang, Jiandong Huang*. Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discovery Today 19(2014)502-509. (IF = 5.964) Yusheng Lu, Ting Yu, Haiyan Liang, Jichuang Wang, Jingjing Xie, Jingwei Shao, Yu Gao, Suhong Yu, Shuming Chen, Lie Wang & Lee Jia. Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade. Sci Rep 4(2014)4344. (IF = 5.078) Jian-Zhong Chen, Ji-Chuang Wang, Yu Gao, Rong-Jie Zeng, Zhou Jiang,Ye-Wei Zhu, Jing-Wei Shao, Lee Jia. A novel UPLC/MS/MS method for rapid determination of metapristonein rat plasma, a new cancer metastasis chemopreventive agentderived from mifepristone (RU486). Journal of Pharmaceutical and Biomedical Analysis 95 (2014) 158–163. (IF = 2.829)