个人简介
EDUCATION
1994-1996 Post-Doctoral Fellow, Department of Medicine, Divisions of Respiratory & Cardiovascular Medicine, Duke University Medical Center, Durham, NC, USA
1990-1994 Ph.D. (Pharmacology), State University of New York, NY, USA: Mentor Dr. Robert F. Furchgott, the 1998 Nobel Laureate.
1984-1987 M.S. (Pharmaceutical Science), China Pharmaceutical University, China
1978-1982 B.S. (Pharmacy), Fudan University, College of Pharmacy, China.
PROFESSIONAL & ADMINISTRATIVE Appointments
01/2012-present Distinguished Professor, “The China Recruitment Program of Global Experts” (1000-talent plan); Founding Director, Cancer Metastasis Prevention & Alert Center, Fuzhou University, China.
09/2014-present Director, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University
12/2015-present Director, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy (Fuzhou University）
4/2005-4/2012 Senior Pharmacologist; Senior Project Officer (Permanent Tenure, GS14/Step 9), Toxicology and Pharmacology Branch, Developmental Therapeutics Program (DTP), Division of Cancer Treatment & Diagnosis, National Cancer Institute/ NIH; Rockville, MD.
4/2002-2005 Senior Pharmacologist; Project Officer (Conditional Tenure, GS14/Step 6), Developmental Therapeutics Program (DTP), Division of Cancer Treatment & Diagnosis, National Cancer Institute/ NIH; Rockville, MD.
2008-Present Visiting Professor, Chinese Academy of Science Key Laboratory for Biomedical Effects of Nanomaterials and Nano-safety, Beijing, China.
2/2000-3/2002 Associate Director, Department of Translational Research; Head, PK/PD Laboratory. Institute for Drug Development/ Cancer Therapy & Research Center, San Antonio, TX;
5/2000-3/2002 Associate Member (equivalent to Associate Professor), San Antonio Cancer Institute, San Antonio, TX.
1998-1999 Group Leader and Member of IACUC (Institutional Animal Care and Use Committee), La Jolla Pharmaceutical Company, San Diego, CA.
1996-1998 Senior Researcher, Dept. of Medicine, Uni. California San Diego, CA.Visiting Scholar, Chinese Academy of Medical Sciences, Beijing, China.
1994-1996 Post-doctor, NitroMed Inc. / Department of Medicine, Divisions of Respiratory & Cardiovascular Medicine, Duke University Medical Center, Durham, NC.
1990-1994 PhD. Research supervised by Dr. Robert F. Furchgott, the 1998 Nobel Laureate, SUNY, NY.
1987-1989 Project Leader, Clinical Pharmacy and Pharmacology, East Hospital, China
近期论文
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Y. Lu, T. Yu, H. Liang, H. Xu, Y. Zhu, Y. Pang, J. Wang, J. Xie, L. Wan, L. Jia. S-nitrosocaptopril Prevents Cancer Metastasis by Inhibiting Adhesion of Circulating Tumor Cells to Endothelial Cells. Abstract AM-14-2797, 2014 AAPS annual meeting, San Diego, USA.
J. Xie, R. Zhao, J. Shao, P. Sinko, Y. Lu, Y. Gao, J. Wang, H. Dong, L. Jia. Increased Capture and Restraint of Hepatocellular Circulating Tumor Cells in Blood by aEpCAM- and aSlex-Coated Dendrimer Conjugates. Abstract AM-14-2260, 2014 AAPS annual meeting, San Diego, USA.
J. Wang, N. Zheng, Y. Zhu, L. Wan, J. Xie, L. Jia. Metapristone Exhibits Anti-metastatic Melanoma B16F10 Activity via Inhibiting the Expression of Integrin &[alpha]4 and Inducing Apoptosis. Abstract AM-14-1672, 2014 AAPS annual meeting, San Diego, USA.
Jingjing Xie1, Haiyan Dong1, Rongli Zhao1, Songen Gu1, Jichuang Wang1, Yusheng Lu1, Patrick J. Sinko2, Ting Yu1, Fangwei Xie3, Lie Wang3，Jingwei, Shao1,4, Lee Jia1,4* Enhanced sensitivity and specificity of capturing and restraining circulating tumour cells in blood with dual antibody-coated nanomaterials2014全国纳米生物与医学学术会议-四川成都2014-11-05
Huo Xu, Yu Gao, Yewei Zhu, Jia Lee*, Formulation, Transdermal Absorption and Penis Relaxation of An Nitric Oxide Donor Drug for its Coating on Condom, 2014,NOV; International Chinese Symposium on free radical research, Hong Kong.
Haiyan Liang, Yusheng Lu, Ting Yu, Shu Lian, Haiyan Dong, Lee Jia*. Enumeration, Characterization and Proliferation of Circulating Tumor Cells for Clinical Application Potential by Flow Cytometry. The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum, The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research. November 15-16, 2014, Hong Kong.
Jian Liu, Hongning Chen, Xiaobo Yu, Liping Xiang, Qiao Tang, Ting Chi , Jinwei Shao*, and Lee Jia* Functionalized PLGA-PEG nanoparticles conjugated with aptamer for targeting circulating tumor cells for drug delivery 2015, April; China Nanomedicine杭州
Yingying Xiao, Yewei Zhu, Jianzhong chen, Tao li , Lee Jia* Bioavailability and Pharmacokinetics of Nanometer Drug of Metapristone in Different Genders, A New Cancer Metastasis Chemopreventive Agent Derived From Mifepristone (RU486) 2015, April; China Nanomedicine杭州
Jingjing Xie1, Hongning Chen1, Yewei Zhu1, Weiyu Shen1, Rongli Zhao1, Lie Wang2, Fangwei Xie2, Lee Jia1,* Dual antibody-functionalized dendrimers for the specific capture of colorectal circulating tumor cells in vitro and in vivo. 2015, April, 9; China Nanomedicine杭州
Xiao-Dong Xie , Feng-Qiao Li, Yu Gao* , Lee Jia* DUAL-APTAMER-MODIFIED-MESOPOROUS SILICA NANOPARTICLES LOADING DOXORUBICIN FOR HIGH EFFICIENT RESTRAINING CANCER METASTASIS. 2015, April 9; China Nanomedicine杭州
Haiyan Dong, Yu Gao, Jingjing Xie, Jingwei Shao, Rodney Ho, Lee Jia From Imitation to Innovation: the Ten-year Chinese Bionanotechnology Development. 2015, April 9 China Nanomedicine April; China Nanomedicine杭州
Jianguo Xu, Haiyan Dong, Weiyu Shen, Sudan He, Hongling Li,Yusheng Lu,Zaisheng Wu*, Lee Jia*. New molecular beacon for detection of p53 gene point mutation and its potential as a primer for polymerization. 2014; Nov. 5-7; SiChuan Chengdu, Nanotechnology meeting.
Ting Chi, Liping Xiang, Xiang Yang, Qiao Tang, Xiaobo Yu, Jian Liu, Yajun Liu,Jingjing Xie, Jingwei Shao*, Lee Jia*.Preparation and Anti-Tumor Activity of mesoporous silica nanoparticles (MSN) containing both free and conjugated ursolic acid (UA@MSN-UA). 2014全国纳米生物与医学学术会议-四川成都2014-11-05
Ting Yu, Yusheng Lu, Haiyan Liang, Yaqiong Pang, Jianguo Xu, Haiyan Dong, Songen Gu, Suhong Yu, Jingwei Shao and Lee Jia*. Nitric Oxide Inhibits Adhesion of Circulating Tumor Cells to Endothelial Cells. 2014 Chemical Biology-Nitric Oxide Shanghai International Conference, Shanghai, July 4-6, 2014.
Dong, H., Lu, Y., Xu, JG., Zheng, N., Liu, J., Jia. L. Bionanotechnology used for capturing and restraining circulating tumor cells: eliminating the suffering and death from cancer metastasis. Beijing, 2015 ChinaNano, Sept. 3-5., 2015.
Jingjing Xie#, Weiyu Shen#, Rongli Zhao, Lee Jia* Enhanced binding and restraint of hepatocellular carcinoma cells by multiple antibodies-conjugated dendrimers. Beijing, 2015 ChinaNano, Sept. 3-5., 2015.
Dong, H., Ma, J., Wang, J., Zhang, T., Wu, ZS., Lu, YS., Han, LY., Jia, L. The novel aptamer cyclization technology: resistant to exonuclease degradation, good biostability and enhanced specificity in binding target cancer cells. AAPS-AM-15-2352
Y. Lu, S. Lian, T. Yu, H. Liang, Y. Zhu, H. Xu, Y. Cheng, H. Dong, L. Jia*. S-nitrosocaptopril as a Potential Cancer Metastatic Chemopreventive Agent: A Promising Molecule for Preventing Cancer Metastasis. AAPS AM-15-1598.
N. Zheng, J. Wang, H. Chen, J. Liu, Y. Lu, H. Dong, L. Jia*. Metapristone Inhibits Cell Mobility and Adhesion of Ovarian Cancer.AAPS AM-15-1737.
Y. Xiao, Y. Zhu, T. Li, Y. Lu, J. Liu, X. Yu, X. Xie, H. Dong, S. Lian, W. Chen, L. Jia*. Metapristone, an active metabolite of mifepristone (RU486), prevent Lewis lung carcinoma cell metastasis. AAPS AM-15-886.
C.Yan , S.He , X.Yang , J.Liu , J.Ma , S.Yu* , L.Jia* Functions and Mechanisms of Metapristone in Triple-negative breast cancer cells. 2015, Nov. AACR Shanghai
H. Chen, G. Zhen, J. Liu , J. Wang , Y. Lu, N. Zhen, C. Ting, Y. Xiao, J. Shao*, L. *Jia Metapristone Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells A549 in vitro. 2015, Nov. AACR Shanghai
Jun Qian, Xiaobo Yu, Xingtian Yang, Hongning Chen, Ting Zhang, Zhou Jiang*, Suhong Yu, Lee Jia** Achyranthes bidentata saponion: a promising cancer metastatic prevention agent. 2015, Nov. AACR Shanghai
N. Zheng, J. C. Wang, J. H. Chen, J. Liu, X. B. YU, Y. S. Lu, X. D. Xie, and L. Jia Metapristone exhibits anti-adhesive activity via down-regulating the expression of multiple adhesion molecules in ovarian cancer SKOV3 cells. A0065 2015, Nov. AACR Shanghai
Xiaobo Yu, Qing Shi, Jian Liu, Yusheng Lu, Ting Chi, Yajun Liu, Jingwei Shao, Lee Jia . Similarities between embryo implantation and circulating tumor cells adhesion to human umbilical vein endothelial cells. 2015, Nov. AACR Shanghai
Ji Ma, Tao Li, Hongning Chen, Cuicui Yan, Yingying Xiao, Lee Jia* The effect of ginseng on the pharmacological function of warfarin in rats.
Yingying Xiao, Yewei Zhu, Yusheng Lu, Wenge Chen, Xiaobo Yu, Hongning Chen, Ting Chi, Jian Liu, Lee Jia* A Novel Anti-metastatic Metapristone Inhibits MCF-7 Adhesion via Down-regulating Expression of MUC-1 Pathway in Vitro and Inhibits Lung Metastasis in Vivo. 2015, Nov. AACR Shanghai
XT. Y, SD.H, CC.Y, SH.Y, L.JIA* Metapristone inhibits cell adhesion with reversal of epithelial-mesenchymal transition in MDA-MB-231 breast cancer cells. 2015, Nov. AACR Shanghai
S.He , C.Yan , X.Yang , S.Yu , L.Jia A pharmacoproteomic study of metapristone: a potential cancer metastatic chemopreventive agent. 2015, Nov. AACR Shanghai
Yusheng Lu, 1Shu Lian, 1Yunlong Cheng, 2Min-Liang Kuo, 1Haiyan Liang, 1Lee Jia*Bioenergetic Adaptation by Metastatic Cancer Cells to Reduce the Unrequired Bioenergy in Emergencies
Shu Lian, 1Yusheng Lu, 2Min-Liang Kuo, 3Alan Yueh-Luen Lee, 1Ting Yu, 1Haiyang Liang, 1Yunlong Cheng, 1Lee Jia S-nitrosocaptopril inhibits expression of cell adhesion molecules via regulating NF-кB signal pathway AAPS abstract poster 2098.
H. Dong1,2, T. Zhang1, L. Han1, J. Ma1, J. Wang1, J. Xie3, Z. Wu1, P.J. Sinko2, Lee Jia*In vivo specifically capturing circulating tumor cells by dual ds-aptamer ring-coated dendrimers,1 2016 AAPS abstract poster 1882
Yunlong Cheng, Yusheng Lu, Shu Lian, Lee Jia. TGF-β Can Enhance the Invasive Ability and the Rate of Metabolism and Proliferation of Cancer Cells. 2016 AAPS abstract poster 1200
Le, JQ, Zheng, TT. Xu, JG, Jia, L. Rapid and Reliable Construction of Aptamer-tethered DNA Nanoarchitecture for Targeted Cancer Therapy. 2016 AAPS poster abstract 1156
Wang, J. Dong, HY., Jia, L. Petitive Pseudo-DNA Nanocatenane for Ultrasensitive CTCs Detection in Peripheral Blood. 2016 AAPS poster Abstract 2111.
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