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研究领域

可完全生物降解医用高分子材料的研究,具体从事智能型水凝胶、微凝胶及纳米胶的合成及其在药物缓释体系的应用;基于天然产物的生物纳米复合物的制备及性能研究;智能型高分子/无机复合材料的开发应用。

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Li Chen*, Zhe Zhang,Xiaofei Chen,Xuemei Yao, Chaoliang He, and Xuesi Chen. Fabrication of modular multifunctional delivery for antitumor drugs based on host-guest recognition, Acta Biomaterialia, Accepted (IF 5.687). Zhiyong Sun, Yangxue Li, Li Chen*, Xiabin Jing and Zhigang Xie. Fluorescent hydrogen-bonded organic framework for sensing of aromatic compounds, Cryst. Growth Des. 2015, 15, 542−545 (IF 4.558). Xiaowei Wu, Yanfang Hu, Xiaohong Wang, Li Chen⁎.Thermo-responsive polymer micelle-based nanoreactors for intelligent polyoxometalate catalysis,Catalysis Communications, 2015, 58,164-168 (IF: 3.32) Li Chen⁎, Zhe Zhang, Xuemei Yao, Xiaofei Chen, Xuesi Chen. Intracellular pH-operated mechanized mesoporous silica nanoparticles as potential drug carries,Microporous and Mesoporous Materials, 2015, 201, 169-175 (IF: 3.209) Zhe Zhang, Xiaofei Chen, Xiaoye Gao, Xuemei Yao, Li Chen*.Targeted dextran-b-poly(3-caprolactone) micelles for cancer treatments,RSC Adv., 2015, 5, 18593-18600 (IF: 3.708) Xiaofei Chen, Xuemei Yao, Li Chen*. Intracellular pH-sensitive dextran-based micelles as efficient drug delivery platforms,Polymer International, 2015, 64(3), 430-436 (IF: 2.458) Xiaofei Chen, Li Chen,* Xuemei Yao, Zhe Zhang, Chaoliang He, Jingping Zhang and Xuesi Chen. Dual responsive supramolecular nanogels for intracellular drug delivery, Chemical Communication, 2014, 50, 3789-3791 (IF: 6.718) Xuemei Yao, Li Chen,* Xiaofei Chen, Zhe Zhang, Hui Zheng, Chaoliang He, Jingping Zhang, and Xuesi Chen. Intracellular pH-sensitive metallo-supramolecular nanogels for anticancer drug delivery, ACS Applied Materials & Interfaces, 2014, 6(10), 7816-7822(IF: 6.008) Xiaowei Wu, Xiaofei Chen, Hongyu Guan, Xiaohong Wang, Li Chen*. A recyclable thermo-responsive catalytic system based on poly(N-isopropylacrylamide)-coated POM@SBA-15 nanospheres, Catalysis Communications, 2014, 51, 29-32 (IF: 3.32) Zhiyong Sun, Yangxue Li, Xingang Guan, Tingting Sun, Li Chen,* Zhigang Xie and Xiabin Jing. A single-step emulsion approach to prepare fluorescent nanoscale coordination polymers for bioimaging, RSC Advances, 2014, 4, 14803-14806 (IF: 3.708) Xuemei Yao, Li Chen*, Xiaofei Chen, Chaoliang He, Hui Zheng, Xuesi Chen. Metallo-supramolecular nanogels for intracellular pH-responsive drug release, Macromolecular Rapid Communications, 2014, 35, 1697-1705 (IF: 4.969) Xuemei Yao, Li Chen*, Xiaofei Chen, Chaoliang He, Hui Zheng, Xuesi Chen. Intercellular pH-responsive histidine modified dextran-g-cholesterol micelle for anticancer drug delivery, Colloids and Surfaces B: Biointerfaces, 2014, 121, 36-43 (IF: 4.287) Li Chen,* Zhe Zhang, Ziwei Zhao, Xiaohong Wang, Xuesi Chen. Polyoxometalates acid treatment for preparing starch nanoparticles, Carbohydrate Polymers, 2014, 112, 520-524 (IF: 3.916) Jianxun Ding, Linghui Chen, Chunsheng Xiao, Li Chen, Xiuli Zhuang, Xuesi Chen. Noncovalent interaction-assisted polymeric micelles for controlled drug delivery, Chem. Commun., 2014, 50, 11274-11290 (IF: 6.718) Xiaofei Chen, Xuemei Yao, Zhe Zhang, Li Chen*. Plug-and-play multifunctional mesoporous silica nanoparticles as potential platforms for cancer therapy, RSC Adv., 2014, 4, 49137-49143 (IF: 3.708) Zhiyong Sun, Yangxue Li, Xingang Guan, Li Chen*,Xiabin Jing, Zhigang Xie. Rational design and synthesis of covalent organic polymers with hollow structure and excellent antibacterial efficacy, RSC Adv., 2014, 4, 40269-40272 (IF: 3.708) Ziwei Zhao, Xuemei Yao, Zhe Zhang, Li Chen*. Boronic acid shell-crosslinked dextran-b-PLA micelles for acid-responsive drug delivery, Macromol. Biosci., 2014, 14, 1609-1618 (IF: 3.742) Xiaowei Wu, Xiaofei Chen, Hongyu Guan, Xiaohong Wang, Li Chen*. Facile one-pot synthesis of mesoporous heteropolyacids-silica hybrid for catalytic wet hydrogen peroxide oxidation of phenol,J Sol-Gel Sci Technol., 2014, 72:663–667 Zhe Zhang, Jianxun Ding, Xiaofei Chen, Chunsheng Xiao, Chaoliang He, Xiuli Zhuang, Li Chen,* and Xuesi Chen. Intracellular pH-Sensitive Supramolecular Amphiphiles Based on Host-Guest Recognition between Benzimidazole and β-Cyclodextrin as Potential Drug Delivery Vehicle, Polymer Chemistry-UK, 2013, 4, 3265-3271 (IF: 5.321) Aiping Zhang, Zhe Zhang, Fenghua Shi, Jianxun Ding, Chunsheng Xiao,Xiuli Zhuang, Chaoliang He, Li Chen* and Xuesi Chen. Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms, Soft Matter, 2013, 9, 2224-2233 (IF: 4.151) Jianxun Ding, Fenghua Shi, Di Li, Li Chen*, Xiuli Zhuang and Xuesi Chen. Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy, Biomaterials Science, 2013, 1, 633-646 Zhe Zhang, Hongling Shan, Jingru Sun, Yun Weng, Xiu Wang, Jie Xiong, Li Chen* and Xuesi Chen. Facile preparation of corn starch nanoparticles by alkali-freezing treatment, RSC Advances, 2013,3(32):13406-13411 (IF: 3.708) Aiping Zhang, Zhe Zhang, Fenghua Shi, Chunsheng Xiao, Jianxun Ding , Xiuli Zhuang, Chaoliang He, Li Chen,* and Xuesi Chen. Redox-sensitive Shell Cross-linked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery, Macromolecular Bioscience, 2013, 13:1249-1258 (IF: 3.742) Zhe Zhang, Hongling Shan, Li Chen,* Chaoliang He, Xiuli Zhuang,and Xuesi Chen.Synthesis of pH-Responsive Starch Nanoparticles Grafted Poly (L-glutamic acid) for Insulin Controlled Release, European Polymer Journal, 2013, 49(8): 2082-2091 (IF: 3.242) Zhe Zhang, Xiaofei Chen, Li Chen,* Shuangjiang Yu, Yue Cao, Chaoliang He, and Xuesi Chen, Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms, ACS Applied Materials & Interfaces, 2013,5(21):10760-10766 (IF: 6.008) Ziwei Zhao, Zhe Zhang, Li Chen,* Yue Cao, Chaoliang He, and Xuesi Chen Biodegradable Stereocomplex Micelles Based on Dextran-block-polylactide as Efficient Drug Deliveries, Langmuir, 2013, 29(42):13072-13080 (IF: 4.384) Fenghua Shi, Jianxun Ding, Xiuli Zhuang, Chunsheng Xiao, Chaoliang He, Li Chen*, Xuesi Chen. Intracellular environment responsive PEGylated polypeptides nanogels with ionizable cores for efficient doxorubicin loading and triggered release,Journal of Materials Chemistry, 2012, 22, 14168-14179 (IF: 6.626) Yunyan Bai, Zhe Zhang, Aiping Zhang, Li Chen,* Chaoliang He, Xiuli Zhuang, Xuesi Chen. Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly(L-glutamic acid)-based microgels for oral insulin controlled release, Carbohydrate Polymers, 2012, 89, 1207-1214 (IF: 3.916) Yunyan Bai, Zhe Zhang, Mingxiao Deng, Li Chen,* Chaoliang He, Xiuli Zhuang, Xuesi Chen. Thermo- and pH-responsive microgels for controlled release of insulin, Polymer International,2012, 61, 1151-1157 (IF: 2.458) Zhe Zhang, Xiaoye Gao, Aiping Zhang, Xiaowei Wu, Li Chen*, Chaoliang He, Xiuli Zhuang, Xuesi Chen. Biodegradable pH-dependent thermo-sensitive hydrogels for oral insulin deliveries, Macromolecular Chemistry and Physics, 2012, 213, 713-719 (IF: 2.451) Jianxun Ding, Fenghua Shi, Chunsheng Xiao, Lin Lin, Li Chen,* Chaoliang He, Xiuli Zhuang, Xuesi Chen. One-step preparation of reduction-responsive poly(ethylene glycol)-poly(amino acid)s nanogels as efficient intracellular drug delivery platforms, Polymer Chemistry, 2011, 2(12), 2857-2864 (IF: 5.325) Zhe Zhang, Li Chen*, Changwen Zhao, Yunyan Bai, Mingxiao Deng, Hongling Shan, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Thermo- and pH-responsive HPC-g-AA/AA hydrogels for controlled drug delivery applications, Polymer, 2011,52(3):676-682 (IF: 3.438) Zhe Zhang, Li Chen*, Mingxiao Deng, Yunyan Bai, Xuesi Chen, Xiabin Jing.Biodegradable thermo- and pH-responsive hydrogels for oral drug delivery, Journal of Polymer Science Part A: Polymer Chemistry,2011,49:2941–2951 (IF: 3.919) Li Chen*, Zhe Zhang, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Compatibilizing effect of starch-grafted-poly(L-lactide) on the poly(e-caprolactone)/starch composites, Journal of Applied Polymer Science, 2010, 117:2724-2731 Li Chen, Zhigang Xie, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Controlled Release of Urea Encapsulated by Starch-g-poly(L-lactide), Carbohydrate Polymers, 2008, 72: 342-348 Li Chen, Zhigang Xie, Junli Hu, Xueyu Qiu, Xuesi Chen, Xiabin Jing. Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as Rifampin delivery,Journal of Nanoparticle Research, 2007,9,777-785 Li Chen, Xueyu Qiu, Mingxiao Deng, Zhongkui Hong, Rui Luo, Xuesi Chen, Xiabin Jing. The starch grafted poly(L-lactide) and the physical properties of its blending composites, Polymer, 2005, 46(15): 5723-5729 Li Chen, Yushan Ni, Xinchao Bian, Xueyu Qiu, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. A novel approach to grafting polymerization of ε-caprolactone onto starch granules, Carbohydrate Polymers, 2005, 60(1): 103-109 Li Chen, Xueyu Qiu, Zhigang Xie, Zhongkui Hong, Jingru Sun, Xuesi Chen, Xiabin Jing. Poly(L-lactide)/starch blends compatibilized with poly(L-lactide)-g-starch copolymer, Carbohydrate Polymers, 2006, 65: 75-80 Chen L, Chen XS, Deng MX, et al., Synthesis and characterization of ABBA block copolymer of glycolide and epsilon-caprolactone, Chemical Research in Chinese Universities, 2005, 21(3): 340-344 Hong Zhongkui, Zhang Peibiao, He Chaoliang, Qiu Xueyu, Liu Aixue, Chen Li, Chen Xuesi, and Jing Xiabin.Nano-composite of Poly(L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility, Biomaterials, 2005, 26(32): 6296-6304 Qiu Xueyu, Hong Zhongkui, Hu Junli, Chen Li, Chen Xuesi, and Jing Xiabin, Hydroxyapatite Surface Modified by L-Lactic Acid and Its Subsequent Grafting Polymerization of L-Lactide, Biomacromolecules, 2005; 6(3); 1193-1199 Xueyu Qiu, Li Chen, Junli Hu, Jingru Sun, Zhongkui Hong, Aixue Liu, Xuesi Chen, Xiabin Jing, Surface-modified hydroxyapatite linked by L-lactic acid oligomer in the absence of catalyst, Journal of Polymer Science Part A: Polymer Chemistry, 2005, 43(21): 5177-5185 Zhigang Xie, Huili Guan, Li Chen, Huayu Tian, Xuesi Chen and Xiabin Jing,Novel biodegradable poly(ethylene glycol)-block-poly(2-methyl-2- carboxyl -propylene carbonate) copolymers: Synthesis, characterization, and micellization, Polymer, 2005, 46(23):10523-10530 Zhigang Xie, Huili Guan, Li Chen, Huayu Tian, Xuesi Chen, Xiabin Jing. Novel biodegradable poly(ethylene glycol)-block-poly(2-methyle-2-carboxyl-propylene carbonate) copolymers: synthesis, characterization, and micellization, Polymer, 2005, 46, 10523-10530. Zhigang Xie, Changhai lu, Xuesi Chen, Li Chen, Yu wang, Xiuli Hu, Quan Shi, Xiabin Jing. Synthesis and Characterization of Novel Poly (carbonate-ester)s Based on Pentaerythritol, Journal of Polymer Science, Part A: Polymer Chemistry, 2007(9), 45, 1737-1745 Zhigang Xie,Changhai lu, Xuesi Chen, Li Chen, Xiuli Hu, Quan Shi, Xiabin Jing. A Facile Approach to Biodegradable Poly(ε-caprolactone)-Poly(ethylene glycol)-Based Polyurethanes Containing Pendant Amino Groups, European Polymer Journal, 2007, 43, 2080-2087 Zhongkui Hong, Peibiao Zhang, Aixue Liu, Chen Li, Xuesi Chen, Xiabin Jing. Composites of poly(lactide-co-glycolide) and the surface modified carbonated hydroxyapatite nanoparticles, Journal of Biomedical Materials Research Part A, 2007, 81A(3), 515-522 Zhongkui Hong, Aixue Liu, Chen Li, Xuesi Chen, Xiabin Jing. Preparation of bioactive glass ceramic nanoparticles by combination of sol-gel and coprecipitation method, J NON-CRYST SOLIDS, 2009, 355:368-372

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