侯智尧 - 广州医科大学

个人简介

1999年09月-2003年06月，哈尔滨工程大学，本科 2005年09月-2009年12月，哈尔滨工程大学，硕博连读 2003年07月-2010年03月，哈尔滨工程大学，助教/讲师 2010年04月-2012年12月，中国科学院长春应用化学研究所，稀土资源利用国家重点实验室，博士后 2013年01月-2018年07月，中国科学院长春应用化学研究所，稀土资源利用国家重点实验室，副研究员 2018年07月-至今，广州医科大学基础医学院，教授

研究领域

针对光能转换材料合成与应用中的基本科学问题，以电子跃迁和稀土离子能量传递为理论基础，结合医学、生物学、材料学和化学等多学科交叉的研究优势，开展新型纳米光能转换材料构建及其在肿瘤光学诊疗中应用的基础研究，实现了多模态影像导航下的近红外光响应抗肿瘤协同治疗；结合肿瘤治疗临床标准开展肿瘤微环境响应的温度可控光热治疗；同时开展纳米光能转换材料在蛋白及核酸的时间分辨检测、牙周相关疾病/神经退行性疾病治疗及骨修复方面的应用研究。

近期论文

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Mengyu Chang, Zhiyao Hou*, Man Wang, Chunxia Li, Jun Lin*, Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy, Advanced Materials, 2021, 2004788. (IF:27.398) Mengyu Chang, Zhiyao Hou*, Dayong Jin*, Jiajia Zhou, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Jun Lin*, Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu2O@CaCO3 Nanocomposites for Synergistic Oncotherapy, Advanced Materials, 2020, 32(43), 2004647. (IF:27.398) Mengyu Chang, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Maolin Pang, Shuzhong Cui, Zhiyao Hou*, Jun Lin*, A Multifunctional Cascade Bioreactor Based on Hollow-Structured Cu2MoS4 for Synergetic Cancer Chemo-Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy, Advanced Materials, 2019, 31(53), 1905271. (IF: 27.398) MeiFang Wang, Kerong Deng, Wei Lü, Xiaoran Deng, Kai Li, Yanshu Shi, Binbin Ding, Ziyong Cheng, Zhiyao Hou*, Jun Lin*, Rational Design of Multifunctional Fe@γ-Fe2O3@H-TiO2 Nanocomposites with Enhanced Magnetic and Photoconversion Effects for Wide Applications: from Photocatalysis to Imaging-guided Photothermal Cancer Therapy, Advanced Materials, 2018, 30(13), 1706747. (IF: 27.398) Bei Liu, Chunxia Li*, Piaoping Yang, Zhiyao Hou*, Jun Lin*, 808-nm-Light-Excited Lanthanide-Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications, Advanced Materials, 2017, 29(18), 1605434. (IF: 27.398, ESI高被引论文) Kerong Deng, Zhiyao Hou*, Xiaoran Deng, Piaoping Yang, Chunxia Li, Jun Lin*, Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W18O49 Nanostructure, Advanced Functional Materials, 2015, 25(47), 7280–7290. (IF:16.836) Zhiyao Hou, Yuanxin Zhang, Kerong Deng, Yinyin Chen, Xuejiao Li, Xiaoran Deng, Ziyong Cheng, Hongzhou Lian, Chunxia Li*, Jun Lin*, UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway, ACS Nano, 2015, 9(3), 2584–2599. (IF:14.588, ESI高被引论文) Meifang Wang, Zhiyao Hou*, Saina Liu, Shuang Liang, Binbin Ding, Yajie Zhao, Mengyu Chang, Gang Han, Abdulaziz A. Al Kheraif, Jun Lin*, A Multifunctional Nanovaccine based on L-Arginine-Loaded Black Mesoporous Titania: Ultrasound-Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy, Small, 2021, 2005728. (IF:11.459) Mengyu Chang, Zhiyao Hou*, Man Wang, Meifang Wang, Peipei Dang, Jianhua Liu, Mengmeng Shu, Binbin Ding, Abdulaziz A. Al Kheraif, Chunxia Li*, Jun Lin*, Cu2MoS4/Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy, Small, 2020, 16(14), 1907146. (IF:11.459) Zhiyao Hou, Kerong Deng, Chunxia Li, Xiaoran Deng, Hongzhou Lian, Ziyong Cheng, Dayong Jin, Jun Lin*, 808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd3+-sensitized upconversion emission with enhanced anti-tumor efficacy, Biomaterials, 2016, 101, 32–46. (IF:10.273)