于海宁 - 大连理工大学 - 生物工程学院

个人简介

个人简介于海宁，辽宁省“百千万人才工程”千人层次人选。2001.7年毕业于北京大学获学士学位，2006.6毕业于University of Iowa（USA）获理学博士学位。参加工作以来，带领的团队致力于生物制药，尤其是蛋白多肽类创新药物研发，从我国特有海洋动物及药源性动物中识别了大量功能分子，建立了天然活性蛋白/多肽分子资源库，并揭示其发挥药效物质基础及机制。共发表SCI论文56篇，第一与通讯作者共36篇，累计影响因子超过250；申请发明专利25项，13项获授权。其中，抗感染及抗炎症双功能肽Hc-CATH于2015年被《Chemical Research in Toxicology》杂志作为焦点研究进行了重点介绍；抗菌肽Cathelicidin-BF于2009年入选Nature China研究亮点。获省部级自然科学奖二等奖一项，省、市级自然科学论文奖一、二、三等奖若干项，2015年8月获得大连市青年科技奖。承担有国家自然科学基金面上及青年基金，各类省部级、市级人才类、自然科学、科技攻关类，企业联合研发项目等共计10余项。抗菌肽Hc-CATH已与山东绿叶集团进行产业化合作；一组皮肤修复肽、促胶原蛋白增生肽、抗氧化肽、抗皮肤光老化肽正与大连毅骏科技有限公司进行后续研发、产业化工作。此外，于海宁老师在高校人才培养方面也成绩斐然。近5年指导的研究生3人获国家奖学金，1人屈伯川奖学金，1人辽宁省优秀毕业生，1人大连市三好学生，1人优秀研究生标兵，1人优秀硕士论文，多人校级优秀毕业生、优秀研究生等。本人获大连理工大学优秀教师，优秀硕士学位论文指导，教学质量优秀奖，大连理工大学优秀班主任等称号。教育经历 1994.9 - 1997.7 大连第24中无专利抑制黑色素生成抗氧化的小肽、制备方法及其应用一类用于促胶原分泌的超短肽及其应用一类抗氧化超短肽及其应用一类促胶原分泌超短肽及其应用中华鳖Cathelicidin—Ps-CATH4肽在制备抗炎症药物中的应用一种抗微生物肽Cm-CATH2及其基因、制备方法和应用科研项目类新型双功能抗血栓药物-Tablysin的研发, 省、市、自治区科技项目, 2013/12/31-2015/12/01, 完成 2013年度辽宁省高等学校优秀人才支持计划（第二层次）, 省、市、自治区科技项目, 2013/06/20-2017/05/16, 完成太平洋鳕鱼cathelicidin免疫功能基因的克隆与表达及其结构与功能研究, 国家自然科学基金项目, 2010/09/25-2013/12/31, 完成缅甸蟒免疫调节肽Cb-CATH1抗耐甲氧西林金黄色葡萄球菌感染的机制研究, 国家自然科学基金项目, 2018/08/16, 进行科研奖励河北省自然科学奖二等奖其他奖励 2017大连理工大学优秀硕士学位论文指导奖 2015第六届大连市青年科技奖 2015校教学质量优良奖 2014大连理工大学优秀硕士学位论文指导奖 2013辽宁省“百千万人才工程”千人层次 2011大连理工大学化工与环境生命学部优秀教师

研究领域

研究方向通过蛋白质组学、基因组学结合药理学手段从我国特有海洋动物及药源性动物尤其富含活性蛋白或多肽类生物活性分子的动物类中药中识别功能分子，采用现代分子生物学技术探明其结构、功能、作用靶标及作用机制，着重筛选具有靶标心血管系统(强心, 降压, 抑制或促进血小板聚集，舒缓平滑肌等), 免疫调节系统（免疫抑制与增强），以及靶标病原性微生物、肿瘤细胞的新型活性肽；建立天然药物活性蛋白/多肽分子资源库，挖掘具有重要药用前景的活性蛋白多肽，为生物制药现代化和创新药物研制及其临床应用奠定理论基础。

近期论文

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[1]Chen, Chen,Wang, Yipeng,Wang, Aili,Zhang, Fen,Zhang, Minghui,Yang, Huaixin,Li, Jianan,Su, Pengchao,Chen, Yan,Yu, Haining.The protective effect of fish-derived cathelicidins on bacterial infections in zebrafish, Danio rerio[J],FISH & SHELLFISH IMMUNOLOGY,2019,92:519-527 [2]Qi Ruo-Han,Chen Yan,Guo Zhi-Lai,Zhang Fen,Fang Zheng,Huang Kai,Yu Hai-Ning,Wang Yi-Peng.Identification and characterization of two novel cathelicidins from the frog Odorrana livida[J],Zoological research,2019,40(2):94-101 [3]Shi Nannan,Cai Shasha,Gao Jiuxiang,Qiao Xue,Yang Huaixin,Wang Yipeng,Yu Haining.Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis[J],Developmental and comparative immunology,2019,92:179-192 [4]Wang, Aili,Zhang, Fen,Guo, Zhilai,Chen, Yan,Zhang, Minghui,Yu, Haining,Wang, Yipeng.Characterization of a Cathelicidin from the Colubrinae Snake, Sinonatrix annularis[J],ZOOLOGICAL SCIENCE,2019,36(1):68-76 [5]于海宁.Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis. [J],Zool Res.,2019,40(2):1-7 [6]Zhang Fen,Guo Zhi-Lai,Chen Yan,Li Li,Yu Hai-Ning,Wang Yi-Peng.Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis[J],Zoological research,2019,40(3):198-204 [7]Feng, Lan,Wang, Yipeng,Yu, Haining,Shi, Nannan,Cai, Shasha,Qiao, Xue,Chu, Peng,Wang, Hui,Long, Feida,Yang, Huaixin,Yang, Yongliang.De Novo Molecular Design of a Novel Octapeptide That Inhibits In Vivo Melanogenesis and Has Great Transdermal Ability[J],JOURNAL OF MEDICINAL CHEMISTRY,2018,61(15):6846-6857 [8]Cai, Shasha,Wang, Yipeng,Yu, Haining,Qiao, Xue,Feng, Lan,Shi, Nannan,Wang, Hui,Yang, Huaixin,Guo, Zhilai,Wang, Mengke,Chen, Yan.Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality.[J],Journal of medicinal chemistry,2018,61(5):2075-2086 [9]于海宁,徐品三,包永明.Transcriptome analysis of tomato leaf spot pathogen Fusarium proliferatum: De novo assembly, expression pro？ling and identi？cation of candidate effectors[J],International Journal of Molecular Sciences,2018,19(1) [10]于海宁. Identification and characterization of two novel cathelicidins from the frog Odorrana livida.[J],Zool Res.,2018,40(2):94-101 [11]Gao Meiling,Yao Siyu,Liu Yang,Yu Haining,Xu Pinsan,Sun Wenhui,Pu Zhongji,Hou Hongman,Bao Yongming.Transcriptome Analysis of Tomato Leaf Spot Pathogen Fusarium proliferatum: De novo Assembly, Expression Profiling, and Identification of Candidate Effectors.[J],International journal of molecular sciences,2017,19(1) [12]高美玲,刘阳,于海宁,侯红漫,包永明.层出镰孢菌原生质体制备条件的研究[J],安徽农业科学,2017,45(35):149-151,163 [13]Guo, Zhilai,Wang, Yipeng,Qiao, Xue,Cheng, Ruomei,Shi, Nannan,Wang, Aili,Feng, Tingting,Chen, Yan,Zhang, Fen,Yu, Haining.As-CATH4 and 5, two vertebrate-derived natural host defense peptides, enhance the immuno-resistance efficiency against bacterial infections in Chinese mitten crab, Eriocheir sinensis[J],FISH & SHELLFISH IMMUNOLOGY,2017,71:202-209 [14]Chen, Yan,Cai, Shasha,Qiao, Xue,Wu, Mali,Guo, Zhilai,Wang, Renping,Kuang, Yi-Qun,Yu, Haining,Wang, Yipeng.As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses[J],BIOCHEMICAL JOURNAL,2017,474(16):2861-2885 [15]Yu, Haining,Wang, Chen,Feng, Lan,Cai, Shasha,Liu, Xuelian,Qiao, Xue,Shi, Nannan,Wang, Hui,Wang, Yipeng.Cathelicidin-trypsin inhibitor loop conjugate represents a promising antibiotic candidate with protease stability[J],SCIENTIFIC REPORTS,2017,7(1):2600 [16]Yu, Haining,Wang, Hui,Liu, Xuelian,Feng, Lan,Qiao, Xue,Cai, Shasha,Shi, Nannan,Wang, Yipeng.Identification, eukaryotic expression and structure & function characterizations of beta-defensin like homologues from Pelodiscus sinensis[J],DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,68:108-117 [17]王晨,冯兰,于海宁,王义鹏.Cathelicidins结构与功能的关系及其分子设计研究进展[J],生物工程学报,2017,33(1):27-35 [18]于海宁,包永明.层出廉孢菌原生质体制备条件的研究[J],安徽农业科学,2017 [19]Yu, Haining,Cai, Shasha,Gao, Jiuxiang,Wang, Chen,Qiao, Xue,Wang, Hui,Feng, Lan,Wang, Yipeng.Express sequence tag analysis - Identification of anseriformes trypsin genes from full-length cDNA library of the duck (Anas platyrhynchos) and characterization of their structure and function[J],BIOCHEMISTRY-MOSCOW,2016,81(2):152-162 [20]Yu, Haining,Liu, Xuelian,Wang, Chen,Qiao, Xue,Wu, Sijin,Wang, Hui,Feng, Lan,Wang, Yipeng.Assessing the potential of four cathelicidins for the management of mouse candidiasis and Candida albicans biofilms[J],BIOCHIMIE,2016,121:268-277 [21]于海宁.Assessing the Potential of Four Cathelicidins for the Management of Mouse Candidiasis and C. albicans Biofilms.[J],Biochimie.,2016,121(1):268-277 [22]于海宁.Identification, eukaryotic expression and structure & function characterizations of β-defensin like homologues from Pelodiscus sinensis.[J],Dev Comp Immunol.,2016,68(1):108-117 [23]Gao, Mei-Ling,Luan, Yu-Shi,Yu, Hai-Ning,Bao, Yong-Ming.First report of tomato leaf spot caused by Fusarium proliferatum in China[J],CANADIAN JOURNAL OF PLANT PATHOLOGY,2016,38(3):400-404 [24]Yu, Haining,Wang, Yipeng,Lu, Yiling,Qiao, Xue,Wei, Lin,Fu, Tingting,Cai, Shasha,Wang, Chen,Liu, Xuelian,Zhong, Shijun.Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity[J],SCIENTIFIC REPORTS,2015,5:11082 [25]Wei, Lin,Wang, Yipeng,Gao, Jiuxiang,Zhang, Shumin,Wu, Sijin,Xie, Zeping,Ling, Guiying,Kuang, Yi-Qun,Yang, Yongliang,Yu, Haining.Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(27):16633-16652 [26]Yu, Haining,Qiao, Xue,Gao, Jiuxiang,Wang, Chen,Cai, Shasha,Feng, Lan,Wang, Hui,Wang, Yipeng.Identification and Characterization of Novel Antioxidant Peptides Involved in Redox Homeostasis of Frog: Limnonectes fragilis[J],PROTEIN AND PEPTIDE LETTERS,2015,22(9):776-784 [27]鲁一灵,高久香,乔雪,王义鹏,于海宁.一种新型改良硫氧还蛋白融合表达体系的建立及cathelicidin家族Lf-CATH2的表达[J],生物工程学报,2015,31(3):403-410 [28]Liu, Han,Yu, Haining,Lai, Ren,Mu, Lixian,Tang, Jing,Shen, Chuanbin,Gao, Chen,Rong, Mingqiang,Zhang, Zhiye,Liu, Jie,Wu, Xiaoyang.A potential wound healing-promoting peptide from frog skin[J],INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2014,49(1):32-41 [29]Ling, Guiying,Gao, Jiuxiang,Zhang, Shumin,Xie, Zeping,Wei, Lin,Yu, Haining,Wang, Yipeng.Cathelicidins from the Bullfrog Rana catesbeiana Provides Novel Template for Peptide Antibiotic Design[J],PLOS ONE,2014,9(3):e93216 [30]于海宁.Geographically Distinct Expression Profile of Host Defense Peptides in the Skin of the Chinese Odorous Frog, Odorrana margaretae.[J],Asian Herpetological Research,2014,4(4):288-297 [31]Ling, Guiying,Li, Li,Gao, Jiuxiang,Yu, Haining,Wang, Yipeng,Zhou, Jiang.Geographically Distinct Expression Profile of Host Defense Peptides in the Skin of the Chinese Odorous Frog, Odorrana margaretae[J],ASIAN HERPETOLOGICAL RESEARCH,2013,4(4):288-297 [32]Yu, Haining,Cai, Shasha,Gao, Jiuxiang,Zhang, Songyan,Lu, Yiling,Qiao, Xue,Yang, Hailong,Wang, Yipeng.Identification and polymorphism discovery of the cathelicidins, Lf-CATHs in ranid amphibian (Limnonectes fragilis)[J],FEBS JOURNAL,2013,280(23):6022-6032 [33]Yu, Haining,Gao, Jiuxiang,Lu, Yiling,Guang, Huijuan,Cai, Shasha,Zhang, Songyan,Wang, Yipeng.Molecular Cloning, Sequence Analysis and Phylogeny of First Caudata G-type Lysozyme in Axolotl (Ambystoma mexicanum)[J],ZOOLOGICAL SCIENCE,2013,30(11):938-943 [34]Zhang, Songyan,Gao, Jiuxiang,Lu, Yiling,Cai, Shasha,Qiao, Xue,Wang, Yipeng,Yu, Haining.Molecular Cloning, Sequence Analysis and Homology Modeling of the First Caudata Amphibian Antifreeze-like Proteinin Axolotl (Ambystoma mexicanum)[J],ZOOLOGICAL SCIENCE,2013,30(8):658-662 [35]Li, Zheng,Zhang, Songyan,Gao, Jiuxiang,Guang, Huijuan,Tian, Yuanyong,Zhao, Zongmao,Wang, Yipeng,Yu, Haining.Structural and functional characterization of CATH_BRALE, the defense molecule in the ancient salmonoid, Brachymystax lenok[J],FISH & SHELLFISH IMMUNOLOGY,2013,34(1):1-7 [36]于海宁.A potential wound healing-promoting peptide from frog skin[J],Int J Biochem Cell Biol.,2013,49(C):32-41 [37]于海宁.Molecular cloning, sequence analysis and homology modeling of the first caudata amphibian antifreeze-like protein in axolotl (Ambystoma mexicanum).[J],Zoolog Sci.,2013,30(8):658-662 [38]广慧娟,厉政,王义鹏,赖仞,于海宁.Cathelicidins家族抗菌肽研究进展[J],动物学研究,2012,33(5):523-526 [39]Hao, Xue,Yang, Hailong,Wei, Ling,Yang, Shilong,Zhu, Wenjuan,Ma, Dongying,Yu, Haining,Lai, Ren.Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate[J],AMINO ACIDS,2012,43(2):677-685 [40]He, Weiyu,Feng, Feifei,Huang, Yong,Guo, Huanhuan,Zhang, Songyan,Li, Zheng,Liu, Jingze,Wang, Yipeng,Yu, Haining.Host defense peptides in skin secretions of Odorrana tiannanensis: Proof for other survival strategy of the frog than merely anti-microbial[J],BIOCHIMIE,2012,94(3):649-655 [41]Zhang, Songyan,Guo, Huanhuan,Shi, Fei,Wang, Hui,Li, Lili,Jiao, Xudong,Wang, Yipeng,Yu, Haining.Hainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis[J],PEPTIDES,2012,33(2):251-257 [42]于海宁.Cathelicidin家族抗菌肽研究进展[J],Zoological Research,2012,33(5):1-4 [43]于海宁.Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae)[J],Peptides,2012,33(1):27-34 [44]于海宁.Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii[J],Biochimie,2012,94(6):1317-1326 [45]于海宁.Chemical punch packed in venoms makes centipedes excellent predators[J],Mol Cell Proteomics,2012,11(9):640-650 [46]Wu, Jing,Liu, Han,Yang, Hailong,Yu, Haining,You, Dewen,Ma, Yufang,Ye, Huahu,Lai, Ren.Proteomic Analysis of Skin Defensive Factors of Tree Frog Hyla simplex[J],JOURNAL OF PROTEOME RESEARCH,2011,10(9):4230-4240 [47]Wang, Yipeng,Lai, Ren,Zhang, Zhiye,Chen, Lingling,Guang, Huijuan,Li, Zheng,Yang, Hailong,Li, Jianxu,You, Dewen,Yu, Haining.Cathelicidin-BF, a Snake Cathelicidin-Derived Antimicrobial Peptide, Could Be an Excellent Therapeutic Agent for Acne Vulgaris[J],PLOS ONE,2011,6(7) [48]Chen, Wenlin,Yang, Xuening,Chen, Lingling,Yang, Xiaolong,Feng, Feifei,He, Weiyu,Liu, Jingze,Yu, Haining.Gene cloning and characterization of novel antinociceptive peptide from the brain of the frog, Odorrana grahami[J],BIOCHIMIE,2011,93(7):1110-1114 [49]Feng, Feifei,Wang, Yipeng,Yu, Haining,Chen, Chen,Zhu, Wenjuan,He, Weiyu,Guang, Huijuan,Li, Zheng,Wang, Duo,Liu, Jingze,Chen, Ming.Gene cloning, expression and characterization of avian cathelicidin orthologs, Cc-CATHs, from Coturnix coturnix[J],FEBS JOURNAL,2011,278(9):1573-1584 [50]Yang, Hailong,Lai, Ren,Wang, Yipeng,Xiao, Yao,Wang, Ying,Wu, Jing,Liu, Cunbao,Ye, Huahu,Li, Fengliang,Yu, Haining.A Bi-Functional Anti-Thrombosis Protein Containing Both Direct-Acting Fibrin(ogen)olytic and Plasminogen-Activating Activities[J],PLOS ONE,2011,6(3) [51]Wang, Yipeng,Yu, Haining,Lu, Zekuan,Feng, Feifei,Zhu, Wei,Guang, Huijuan,Liu, Jingze,He, Weiyu,Chi, Lianli,Li, Zheng.Molecular cloning and characterization of novel cathelicidin-derived myeloid antimicrobial peptide from Phasianus colchicus[J],DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2011,35(3):314-322 [52]于海宁.Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate.[J],Amino Acids.,2011 [53]于海宁.A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana.[J],J Pept Sci.,2011,17(7):540-544 [54]Zheng, Ruiqiang,Yao, Bin,Yu, Haining,Wang, Hanjin,Bian, Jianmin,Feng, Feifei.Novel family of antimicrobial peptides from the skin of Rana shuchinae[J],PEPTIDES,2010,31(9):1674-1677 [55]Wu, Jing,Wang, Yipeng,Liu, Han,Yang, Hailong,Ma, Dongying,Li, Jianxu,Li, Dongsheng,Lai, Ren,Yu, Haining.Two Immunoregulatory Peptides with Antioxidant Activity from Tick Salivary Glands[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2010,285(22):16606-16613 [56]Lu, Zekuan,Zhai, Lei,Wang, Hui,Che, Qiaolin,Wang, Duo,Feng, Feifei,Zhao, Zongmao,Yu, Haining.Novel families of antimicrobial peptides with multiple functions from skin of Xizang plateau frog, Nanorana parkeri[J],BIOCHIMIE,2010,92(5):475-481 [57]Lu, Zekuan,Lai, Ren,Yu, Haining,Wang, Yipeng,Zhai, Lei,Che, Qiaolin,Wang, Hui,Du, Shuyuan,Wang, Duo,Feng, Feifei,Liu, Jingze.Novel cathelicidin-derived antimicrobial peptides from Equus asinus[J],FEBS JOURNAL,2010,277(10):2329-2339 [58]Lu, Xiangyun,Chen, Qiaolin,Lv, Yi,Wang, Meijuan,Lu, Zekuan,Feng, Feifei,Liu, Jingze,Yu, Haining.A novel defensin-like peptide from salivary glands of the hard tick, Haemaphysalis longicornis[J],PROTEIN SCIENCE,2010,19(3):392-397 [59]于海宁.Two novel antimicrobial peptides from centipede venoms.[J],Toxicon.,2010,55(2-3):274-279 [60]于海宁.Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.[J],Genomics,2010,95(1):66-71 [61]于海宁.Two tachykinin-like peptides from skin secretions of Danio rerio.[J],J. Pep. Sci.,2010,16(2):81-84 [62]于海宁.Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae). [J],Biochimie.,2009,91(4):540-547 [63]于海宁.The first gene-encoded amphibian neurotoxin. [J],J Biol Chem.,2009,284(33):22079-22086 [64]于海宁.The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae).[J],Peptides.,2009,30(2):273-282 [65]于海宁. Immunoregulatory peptides from salivary glands of the horsefly, Tabanus pleskei.[J],Comp Biochem Physiol B Biochem Mol Biol.,2009,154(1):1-5 [66]于海宁.A novel serine protease inhibitor from the venom of Vespa bicolor Fabricius. [J],Comp Biochem Physiol B Biochem Mol Biol.,2009,153(1):116-120 [67]于海宁.A novel serine protease inhibitor from Bungarus fasciatus venom. [J],Peptides.,2008,29(3):369-374 [68]于海宁.A serine proteinase inhibitor from frog eggs with bacteriostatic activity. [J],Comp Biochem Physiol B Biochem Mol Biol.,2008,149(1):58-62 [69]于海宁.An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides. [J],Dev Comp Immunol.,2008,32(10):1242-1247 [70]于海宁. Antimicrobial peptides from the venoms of Vespa bicolor Fabricius. [J],Peptides.,2008,29(11):1887-1892 [71]于海宁.A bactericidal homodimeric phospholipases A2 from Bungarus fasciatus venom. [J],Peptides.,2007,28(5):969-973 [72]于海宁.Anti-infection peptidomics of amphibian skin.[J],Mol Cell Proteomics.,2007,6(5):882-894 [73]于海宁.Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahami. [J],Genomics.,2007,89(3):413-418 [74]于海宁.Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides. [J],FASEB J.,2007,21(10):2466-2473 [75]于海宁.Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith).[J],Toxicon.,2007,50(3):377-382 [76]于海宁.A novel algesic peptide derived from skin secretions of the frog Amolops loloensis. [J],J Pept Sci.,2007,13(12):798-802 [77]于海宁.The mastoparanogen from wasp.[J],Peptides.,2006,27(12):3053-3057 [78]于海宁.A tick B-cell inhibitory protein from salivary glands of the hard tick, Hyalomma asiaticum asiaticum. [J],Biochem Biophys Res Commun.,2006,343(2):585-590 [79]于海宁.Direct antimicrobial activities of PR-bombesin. [J],Life Science.,2006,78(17):1953-1956 [80]于海宁.Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis. [J],Peptides.,2006,27(12):3085-3091 [81]于海宁.Kinetic studies on the interaction of heparin and complement proteins using surface plasmon resonance. [J],Bioch. Biophy. Acta.,2005,172(2):168-176 [82]于海宁.Poly(ethylene glycol)-based biosensor chip to study heparin protein interactions. [J],Analytical Biochmesitry.,2005,343(1):176-178 [83]于海宁.Studies of the interaction between proteoglycan and proteins of biological importance[A],226th National Meeting of the American Chemical Society,2003