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个人简介

教育经历 2007.4 2010.12 九州工业大学 功能生物分子 博士 1999.4 2001.3 九州工业大学 功能生物分子 硕士 1982.9 1986.7 吉林农业大学 药用植物 学士 1980.9 1982.7 长春市十一高中 无 工作经历 2003.5 至今 大连理工大学 副教授

研究领域

多肽药物 功能性药用材料 天然活性物质

近期论文

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Yan, Chunli.Comparative molecular dynamics simulations of histone deacetylase-like protein: Binding modes a...[J],PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2021,73(1):134-149 白月洁,方燕秋,李晓晖,孙玉明,韩春晖.帕洛诺司琼贴片的体外透过性能及在大鼠体内的药动学[J],中国医药工业杂志,2020,51(1):75-80 田甜,李晓晖,汪晴.细胞促渗肽促进药物细胞摄取的研究进展[J],中国药学杂志,2019,16:1285-1291 Huang, Meiling,Zhang, Jian,Yan, Changjiao,Li, Xiaohui,Zhang, Juliang,Ling, Rui.Small molecule HDAC inhibitors: Promising agents for breast cancer treatment[J],BIOORGANIC CHEMISTRY,2019,91:103184 Li, Xiaohui,Liu, Lifen,Yang, Fenglin.CFC/PVDF/GO-Fe3+ membrane electrode and flow-through system improved E-Fenton performance with ...[J],SEPARATION AND PURIFICATION TECHNOLOGY,2018,193:220-231 Pu, Tingting,Li, Xiaohui,Sun, Yuming,Ding, Xue,Pan, Yaqing,Wang, Qing.Development of a Prolonged-Release Pramipexole Transdermal Patch: In Vitro and In Vivo Evaluati...[J],AAPS PHARMSCITECH,2017,18(3):738-748 周栋栋,李晓晖.海带提取物、枸杞子和山药混合物对糖尿病模型大鼠的降血糖作用[J],中国生化药物杂志,2017,37(1):23-26 Ding, Xue,Sun, Yuming,Wang, Qing,Pu, Tingting,Li, Xiaohui,Pan, Yaqing,Yang, Yang.Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after transderma...[J],PHYTOMEDICINE,2016,23(8):864-871 李晓晖,王燕云,田甜,汪晴.促渗肽协同抗癌药物作用于肿瘤细胞的生物活性评价[J],中国生化药物杂志,2016,5:12-15 李晓晖,孙玉明,汪晴.Development of a Prolonged-Release Pramipexole Transdermal Patch: In Vitro and In Vivo Evaluation[J],Aaps Pharmscitech,2016,1:1-11 李晓晖,王燕云,田甜,汪晴.促渗肽协同抗癌药物对肿瘤细胞作用的生物活性评价[J],中国生化药物杂志,2016,36(5):12-15 Sun, Yuming,Yang, Yang,Li, Xiaohui,Chang, Mingming,Li, Dong,Pu, Tingting,Ding, Xue,Wang, Qing,Wang, Yulin.Effect of glycyrrhizic acid on the oral absorption of paeoniflorin in rats in vivo[J],RSC ADVANCES,2016,6(52):46925-46928 李晓晖,汪晴,修志龙.Autophagy inhibitor sensitized MCF-7 breast cancer cells 1 to novel cyclic tetrapeptide CTS203-in...[J],Neoplasma,2015,62(2) Wang, S.,Li, X.,Wang, Q.,Xiu, Z..Autophagy inhibitor sensitizes MCF-7 breast cancer cells to novel cyclic tetrapeptide CTS203-in...[J],NEOPLASMA,2015,62(2):220-229 李晓晖,黄美玲,刘丽娜,王燕云.环肽类组蛋白去乙酰化酶抑制剂[J],化学进展,2014,26(09):1527-1536 Wang, Shi-Miao,Li, Xiao-Hui,Xiu, Zhi-Long.Over-Expression of Beclin-1 Facilitates Acquired Resistance to Histone Deacetylase Inhibitor-In...[J],ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(18):7913-7917 Wang, Shimiao,Li, Xiaohui,Wei, Yingdong,Xiu, Zhilong,Nishino, Norikazu.Discovery of Potent HDAC Inhibitors Based on Chlamydocin with Inhibitory Effects on Cell Migrat...[J],CHEMMEDCHEM,2014,9(3,SI):627-637 Tong, Xiao,Wang, Qing,Wang, Hai-xia,Li, Xiao-Hui,Wu, Wei,Che, Xin-yi.Fabrication of pH sensitive amphiphilic hot-melt pressure sensitive adhesives for transdermal d...[J],INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES,2014,48:217-223 李晓晖,常明明,汪晴,孙玉明,刘洋.阳离子环肽对Caco-2细胞膜超微结构与渗透性的影响[J],药学学报,2014,49(7):1062-1068 李晓晖,修志龙.Discovery of Potent HDAC inhibitors Based on Chlamydocin with Inhibitory Effect on Cell Migration[J],ChemMedChem,2014,9(3):627-637 李晓晖,黄美玲,刘丽娜,王燕云.环肽类组蛋白去乙酰化酶抑制剂的研究进展[J],化学进展,2014,26(9):1527-1536 何俊,李晓晖,常明明,汪晴.促进药物经皮吸收的促渗肽研究进展[J],中国药学杂志,2014,49(8):627-631 曹文静,修志龙,李晓晖,牟英,沈俊涛,惠欢庆.混合溶剂提取南极磷虾油的工艺研究[J],中国油脂,2013,38(12):6-9 常明明,李晓晖,孙玉明,汪晴.具有经皮促渗功能的阳离子环肽构效关系研究[A],2013,544-546 Chang, Mingming,Li, Yueqing,Zhao, Weijie,Wang, Qing,Li, Xiaohui,Sun, Yuming,Cheng, Fang.A Potential Mechanism of a Cationic Cyclopeptide for Enhancing Insulin Delivery across Caco-2 C...[J],BIOLOGICAL & PHARMACEUTICAL BULLETIN,2013,36(10):1602-1607 Hu, Y.N.,Wang, Q.,Sun, Y.M.,Li, X.H.,Che, X.Y.,Zhang, H.H..Studies on in vitro release performance of hydrophilic drugs and lipophilic drugs in amphiphilic ...[J],Applied Mechanics and Materials,2013,395-396:389-398 Li, Xiao-Hui,Huang, Mei-Ling,Wang, Shi-Miao,Wang, Qing.Selective Inhibition of Bicyclic Tetrapeptide Histone Deacetylase Inhibitor on HDAC4 and K562 L...[J],ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2013,14(12):7095-7100 Chang, Mingming,Li, Xiaohui,Sun, Yuming,Cheng, Fang,Wang, Qing,Xie, Xiaohuan,Zhao, Weijie,Tian, Xin.Effect of Cationic Cyclopeptides on Transdermal and Transmembrane Delivery of Insulin[J],MOLECULAR PHARMACEUTICS,2013,10(3):951-957 李晓晖,汪晴.Selective Inhibition of Bicyclic Tetrapeptide Histone Deacetylase[J],Asian Pacific Journal of Cancer Prevention,2013,14(14):7095-7100 Zhao, Zhong-fu,Fang, Bing,Li, Xiaohui,Wang, Qing.Development of hot-melt pressuresensitive adhesives for transdermal drug delivery[J],JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY,2013,27(2):143-153 Li Xiao-hui,Wei Ying-dong,Wang Shi-miao,Wang Meng-nan,Huang Da-wei,Xiu Zhi-long.Synthesis, Biological Evaluation and Molecular Modeling of Cyclic Tetrapeptide Based Inhibitors...[J],CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2012,28(6):1011-1016 Huang, Dawei,Li, Xiaohui,Xiu, Zhilong.MOLECULAR MODELING OF THE INTERACTIONS BETWEEN HISTONE DEACETYLASE 8 AND INHIBITORS[J],JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY,2012,11(4):907-924 Huang, Dawei,Li, Xiaohui,Wei, Yingdong,Xiu, Zhilong.A novel series of L-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivative...[J],EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2012,52:111-122 Huang, Dawei,Li, Xiaohui,Sun, Lei,Xiu, Zhilong,Nishino, Norikazu.Synthesis, evaluation and molecular modeling of cyclic tetrapeptide histone deacetylase inhibit...[J],JOURNAL OF PEPTIDE SCIENCE,2012,18(4):242-251 Sun Yang,Huang Da-wei,Li Xiao-hui,Hu Jian-en,Xiu Zhi-long.Microwave-assisted Solid-phase Synthesis, Biological Evaluation and Molecular Docking of Angiot...[J],CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2012,28(1):108-113 李晓晖,黄大卫,孙蕾,修志龙,西野宪和.基于Chlamydocin骨架设计合成环肽类HDACi及其抗肿瘤活性[J],有机化学,2011,31(3):312-316 李晓晖,王帅,惠欢庆,胡建恩,修志龙.血红蛋白β-链片段合成及生物活性[J],药学学报,2010,45(10):1270-1274 王旭东,李晓晖,苏志国,修志龙.蛋白药物的聚乙二醇定点修饰策略与最佳位点[J],中国生物工程杂志,2010,30(4):101-109 李晓晖,赵俊伟,滕虎,西野宪和,修志龙.Apicidin选择性抑制ClassⅠ HDACs分子动力学研究[J],高等学校化学学报,2010,31(2):374-378 李晓晖,王帅,惠欢庆,胡建恩,修志龙.血红蛋白beta-链片段合成及生物活性[J],药学学报,2010,45(10):1270-1274

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