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个人简介

教育经历 1984.9 1987.7 石家庄市第一中学 无 2003.9 2006.7 中国协和医科大学 生药学 博士 1999.9 2001.7 河北医科大学 药物化学 硕士 1987.9 1991.7 大连理工大学 化学工程 学士 工作经历 2006.11 至今 大连理工大学 副教授 1997.5 1999.5 日本东京北里研究所 留学研究员 1991.7 2006.11 华北制药集团新药中心 室主任

研究领域

1. 降糖复方药物及功能食品及作用机制研究 2. 现代生物技术发现先导药物及其机制 3. 药物分离新技术、新方法研究

近期论文

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董悦生.Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through...[J],MOLECULES,2021,25(3) Zhang, Zhi-Rong.Separation and purification of Klebsiella phage by two-step salting-out extraction[J],SEPARATION AND PURIFICATION TECHNOLOGY,2021,242 董悦生.Dietary 5,6,7-Trihydroxy-flavonoid Aglycones and 1-Deoxynojirimycin Synergistically Inhibit the...[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021,68(33):8774-8787 Qin, Yuanhua,Zhang, Zhongpei,Zheng, Lili,Wu, Haiyan,Dai, Xiaodong,Dong, Yuesheng,Cui, Yu,Ren, Yixin.Impact of Wortmannilactone F and G31P on Clonorchis Sinensis-infected mice[J],INTERNATIONAL IMMUNOPHARMACOLOGY,2020,85 Qin, Yuanhua,Ren, Yixin,Yi, Cen,Chileshe, Nawila,Chen, Yufeng,Zheng, Lili,Dai, Xiaodong,Dong, Yuesheng,Cui, Yu.Effect of Wortmannilactone F on Trichinella spiralis Enteral in Mice[J],VECTOR-BORNE AND ZOONOTIC DISEASES,2020,20(3):205-211 王路路,董悦生.Cytosolic 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase MtaNfrom Mycobacterium. sme...[J],Biodesign,2019,7:61-66 Dai, Jian-Ying,Yang, Yu,Dong, Yue-Sheng,Xiu, Zhi-Long.Solid-state Co-cultivation of Bacillus subtilis, Bacillus mucilaginosus, and Paecilomyces lilac...[J],APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2020,190(3):1092-1105 张博崴,董悦生,于娜,孙玉明.Intestinal metabolism of baicalein after oral administration in mice:[J],Journal of Functional Foods,2019,54:53-63 Wang, Lulu,Dong, Yuesheng,Nam, Ki Hyun,Ha, Nam-Chul,Gao, Peng,Lan, Jing,Liu, Wei,Shang, Fei,Chen, Yuanyuan,Xu, Yongbin,Quan, Chunshan.Structural insight into the carboxylesterase BioH from Klebsiella pneumoniae[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,520(3):538-543 Dai Jian-Ying,Yang Yu,Dong Yue-Sheng,Xiu Zhi-Long.Solid-state Co-cultivation of Bacillus subtilis, Bacillus mucilaginosus, and Paecilomyces lilacin...[J],Applied biochemistry and biotechnology,2019 Qin Yuanhua,Ren Yixin,Yi Cen,Chileshe Nawila,Chen Yufeng,Zheng Lili,Dai Xiaodong,Dong Yuesheng,Cui Yu.Effect of Wortmannilactone F on Trichinella spiralis Enteral in Mice[J],Vector borne and zoonotic diseases (Larchmont, N.Y.),2019 Ding, Qianzhi,Ma, Baiping,Yan, Renyi,Zhang, Tao,Yu, Liyan,Dong, Yuesheng,Zhang, Bowei,Zheng, Wei,Chen, Xiaojuan,Zhang, Jie.Liupao tea extract alleviates diabetes mellitus and modulates gut microbiota in rats induced by...[J],BIOMEDICINE PHARMACOTHERAPY,2019,118:109262 Wang Lulu,Quan Chunshan,Xu Yongbin,Chen Yuanyuan,Shang Fei,Liu Wei,Lan Jing,Gao Peng,Ha Nam-Chul,Nam Ki Hyun,Dong Yuesheng.Structural insight into the carboxylesterase BioH from Klebsiella pneumoniae[J],Biochemical and biophysical research communications,2019 Ding, Qianzhi,Zheng, Wei,Zhang, Bowei,Chen, Xiaojuan,Zhang, Jie,Pang, Xu,Zhang, Yong,Jia, Dexian,Pei, Surui,Dong, Yuesheng,Ma, Baiping.Comparison of hypoglycemic effects of ripened pu-erh tea and raw pu-erh tea in streptozotocin-i...[J],RSC ADVANCES,2019,9(6):2967-2977 Dong, Yue-Sheng,Yang, Fan,Liu, Wen-Cai,Wang, Xu-Dong,Xing, Yan,Xiu, Zhi-Long.Separation and purification of wortmannilactone analogues by three-liquid-phase salting-out ext...[J],SEPARATION AND PURIFICATION TECHNOLOGY,2019,224:397-404 Ren, Yixin,Qin, Yuanhua,Zhang, Xueqiang,Zheng, Lili,Dai, Xiaodong,Wu, Haiyan,Dong, Yuesheng,Cui, Yu.Killing the muscular larvae of Trichinella spiralis and the anti-fibrotic effect of the combina...[J],BIOMEDICINE PHARMACOTHERAPY,2018,108:934-940 Chen, Jinli,Nam, Ki Hyun,Xu, Yongbin,Shang, Fei,Wang, Lulu,Zou, Linhai,Bu, Tingting,Jin, Liming,Dong, Yuesheng,Ha, Nam-Chul,Quan, Chunshan.Structural and Biochemical Analysis of the Citrate-Responsive Mechanism of the Regulatory Domai...[J],BIOCHEMISTRY,2018,57(42):6054-6060 Shang, Fei,Quan, Chunshan,Xu, Yongbin,Chen, Jinli,Wang, Lulu,Zou, Linhai,Bu, Tingting,Dong, Yuesheng,Ha, Nam-Chul,Nam, Ki Hyun,Jin, Liming.Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):2906-2911 Zhang, Bowei,Xiu, Zhilong,Ma, Baiping,Yu, Liyan,Dong, Yuesheng,Sun, Wenlong,Yu, Na,Sun, Jin,Yu, Xiaoxia,Li, Xia,Xing, Yan,Yan, Dong,Ding, Qianzhi.Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in strept...[J],JOURNAL OF FUNCTIONAL FOODS,2018,46:256-267 胡春燕,王旭东,秦超,董悦生,修志龙.克拉维酸钾一步结晶工艺优化[J],高校化学工程学报,2018,32(4):910-917 Chen, Jinli,Wang, Lulu,Shang, Fei,Dong, Yuesheng,Ha, Nam-Chul,Nam, Ki Hyun,Quan, Chunshan,Xu, Yongbin.Crystal structure of E. coli ZinT with one zinc-binding mode and complexed with citrate[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,500(2):139-144 Xing, Yan,Chen, Chaonan,Sun, Wenlong,Zhang, Bowei,Sang, Yuanbin,Xiu, Zhilong,Dong, Yuesheng.An environment-friendly approach to isolate and purify glucan from spent cells of recombinant P...[J],ENGINEERING IN LIFE SCIENCES,2018,18(4):227-235 Sun Wenlong,Zhang Bowei,Yu Xiaoxia,Zhuang Chunlin,Li Xia,Sun Jin,Xing Yan,Xiu Zhilong,Dong Yuesheng.Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozo...[J],Phytomedicine : international journal of phytotherapy and phytopharmacology,2018,38:24-34 Liu, Wen-Cai,Dong, Yue-Sheng,Ren, Yi-Xin,Hao, Ai-Yu,Yu, Sun,Shi, Xuan,Zhang, Xue-Qiang,Xing, Yan,Xiu, Zhi-Long,Cui, Yu.The activities of wortmannilactones against helminth electron transport chain enzymes, structure-...[J],The Journal of antibiotics,2018,71(8):731-740 Zhang, Bo-wei,Xing, Yan,Wen, Chen,Yu, Xiao-xia,Sun, Wen-long,Xiu, Zhi-long,Dong, Yue-sheng.Pentacyclic triterpenes as alpha-glucosidase and alpha-amylase inhibitors: Structure-activity r...[J],BIOORGANIC MEDICINAL CHEMISTRY LETTERS,2017,27(22):5065-5070 王路路,权春善,许永斌,陈金利,吴懿,王冠天,董悦生.金黄色葡萄球菌arl双组分信号转导系统受体蛋白ArlSCA的表达、纯化及活性研究[J],中国生物工程杂志,2017,37(11):52-58 Xu, Yongbin,Jo, Inseong,Wang, Lulu,Chen, Jinli,Fan, Shengdi,Dong, Yuesheng,Quan, Chunshan,Ha, Nam-Chul.Hexameric assembly of membrane fusion protein YknX of the sporulation delaying efflux pump from...[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,493(1):152-157 Xu, Yongbin,Wang, Lulu,Chen, Jinli,Zhao, Jing,Fan, Shengdi,Dong, Yuesheng,Ha, Nam-Chul,Quan, Chunshan.Structural and Functional Analyses of Periplasmic 5 '-Methylthioadenosine/S-Adenosylhomocystein...[J],BIOCHEMISTRY,2017,56(40):5347-5355 Sun, Wenlong,Sun, Jin,Zhang, Bowei,Xing, Yan,Yu, Xiaoxia,Li, Xia,Xiu, Zhilong,Dong, Yuesheng.Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose ...[J],JOURNAL OF FUNCTIONAL FOODS,2017,37:339-353 Zhang, Bo-wei,Li, Xia,Xiu, Zhi-long,Zhuang, Chun-lin,Dong, Yue-sheng,Sun, Wen-long,Xing, Yan.Dietary Flavonoids and Acarbose Synergistically Inhibit alpha-Glucosidase and Lower Postprandia...[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(38):8319-8330 Duan, Liying,Ye, Junwei,Sun, Wenlong,Gong, Wei-tao,Dong, Yuesheng,Ning, Guiling,Wang, Shaoning.A novel PTP1b inhibitor vanadium-flavone complex: synthesis and pharmacodynamic evaluation in s...[J],MEDICINAL CHEMISTRY RESEARCH,2017,26(9):1863-1870 Sun, Wenlong,Zhuang, Chunlin,Li, Xia,Zhang, Bowei,Lu, Xinhua,Zheng, Zhihui,Dong, Yuesheng.Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activ...[J],BIOORGANIC MEDICINAL CHEMISTRY LETTERS,2017,27(15):3382-3385 Zhang, Bo-wei,Sang, Yuan-bin,Sun, Wen-long,Yu, He-shui,Ma, Bai-ping,Xiu, Zhi-long,Dong, Yue-sheng.Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibit...[J],BIOMEDICINE PHARMACOTHERAPY,2017,91:890-898 胡春燕,秦超,王旭东,董悦生,李树有,冯涛,王启斌,修志龙.克拉维酸在乙酸乙酯中的稳定性[J],高校化学工程学报,2017,31(2):270-275 Sun, Wenlong,Sang, Yuanbin,Zhang, Bowei,Yu, Xiaoxia,Xu, Qinmin,Xiu, Zhilong,Dong, Yuesheng.Synergistic effects of acarbose and an Oroxylum indicum seed extract in streptozotocin and high...[J],BIOMEDICINE PHARMACOTHERAPY,2017,87:160-170 Zheng, Weilong,Wang, Xudong,Cao, Wenjing,Yang, Bowen,Mu, Ying,Dong, Yuesheng,Xiu, Zhilong.E-configuration structures of EPA and DHA derived from Euphausia superba and their significant ...[J],PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS,2017,117:47-53 Sun, Wenlong,Xiu, Zhilong,Zhang, Bowei,Zheng, Haizhou,Zhuang, Chunlin,Li, Xia,Lu, Xinhua,Quan, Chunshan,Dong, Yuesheng,Zheng, Zhihui.Trivaric acid, a new inhibitor of PTP1b with potent beneficial effect on diabetes[J],LIFE SCIENCES,2017,169:52-64 董悦生,修志龙.E-configuration structures of EPA and DHA derived from Euphausia superba andtheirsignificant inhi...[J],Prostaglandins, Leukotrienes and Essential Fatty Acids,2017,117(1):47-53 Liu, Wen-Cai,Yang, Fan,Zhang, Ran,Shi, Xuan,Lu, Xin-Hua,Luan, Yu-Shi,Xiu, Zhi-Long,Dong, Yue-Sheng.Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using...[J],PHYTOCHEMISTRY LETTERS,2016,18:157-161 Liu, Wen-Cai,Wang, Yi-Yu,Liu, Jun-Hui,Ke, Ai-Bing,Zheng, Zhi-Hui,Lu, Xin-Hua,Luan, Yu-Shi,Xiu, Zhi-Long,Dong, Yue-Sheng.Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilid...[J],BIOORGANIC MEDICINAL CHEMISTRY LETTERS,2016,26(21):5328-5333

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