个人简介
2023/1-今,大连理工大学,生物工程学院,教授
2019/12-今,大连理工大学,生物工程学院,博士生导师
2017/12-2022/12,大连理工大学,生物工程学院,副教授
2014/08-2017/11,大连理工大学,生命科学与技术学院,讲师
2012/08-2014/07,大连理工大学,生命科学与技术学院,师资博士后
2011/09-2011/12,西班牙CICbiomaGUNE生物材料研究中心,访问学者
2006/09-2012/03,浙江大学,材料科学与工程专业,博士学位(保研)
2002/09-2006/07,湖南大学,材料科学与工程专业,学士学位
研究领域
1)构筑与肿瘤细胞结构、生化特征精确匹配的材料表界面,提高血液中循环肿瘤细胞捕获效率和广谱性,用于癌症的早期检测;2) 研制与循环肿瘤细胞生长自适应的水凝胶材料,提高循环肿瘤细胞类器官培养效率,用于癌症的个体化药物筛选;3)结合材料学与合成生物学,开发微生物复合的可编程活体材料,应用于生物传感、疾病治疗等领域。
近期论文
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Chong Zhang, Fen Zeng, Zhengyang Fan, Zhen He, Liang Tai, Qiang Peng, Yixin Zhang, Zhenhua Chao, Wenning Jiang, Lingyun Jia*, Lulu Han*. An Oral Polyphenol Host-Guest Nanoparticle for Targeted Therapy of Inflammatory Bowel Disease. Acta Biomaterialia, 2023. https://doi.org/10.1016/j.actbio.2023.08.020
Chong Zhang, Xiaorong Gao, Xinxiu Ren, Ting Xu, Qiang Peng, Yixin Zhang, Zhenhua Chao, Wenning Jiang, Lingyun Jia*, Lulu Han*. Bacteria-Induced Colloidal Encapsulation for Probiotic Oral Delivery. ACS Nano, 2023, 17 (7), 6886–6898. (纳米领域TOP期刊,中科院一区,影响因子18.027)
Wenning Jiang, Lulu Han*, Guorui Li, Ying Yang, Qidong Shen, Bo Fan, Yuchao Wang, Xiaomin Yu, Yan Sun, Shengxiu He, Huakun Du, Jian Miao, Yuefeng Wang, and Lingyun Jia*. Bait-trap chip for accurate and ultrasensitive capture of living circulating tumor cells. Acta Biomaterialia, 2023, 162, 226-239.
Lulu Han, Jiaxin Ji, Chong Zhang, Bingjian Sun, Zhenhua Chao, Hua Zhu, Xiaorong Gao Jun Ren, Fangling Ji, Liming Ma, Lingyun Jia*. One-Step Assembly of Versatile Multifunctional Coatings Based on Host-Guest and Polyphenol Chemistry. Small, 2023, e2206943, DOI: 10.1002/smll.202206943. (中科院一区,影响因子15.153, 入选Inside back cover)
Ting Xu, Lulu Han*, Lingyun Jia*. Facile calcium ion-regulated grafting of dense and highly stretched hyaluronan for selective mediation of cancer cells rolling under high-speed flow. Acta Biomaterialia, 2022, 146, 177-186.
Wenning Jiang, Lulu Han*, Liwei Yang, Ting Xu, Jiabei He, Ruilian Peng, Ziyu Liu, Chong Zhang, Xiaomin Yu, Lingyun Jia*. Natural fish trap-like nanocage for label-free capture of circulating tumor cells. Advanced Science, 2020, 7, 2002259.
Lingyu Li, Lulu Han*, Jian Xie, Shuxin Liu, Lingyun Jia*. Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis. Carbohydrate Polymers, 2020, 247, 116665.
Lulu Han, Ruilian Peng, Wenning Jiang, Ting Xu, Chong Zhang, Kaidi Chen, Yixin Zhang, Haiyuan Song, Lingyun Jia*. Coordination-driven reversible surfaces with site-specifically immobilized nanobody for dynamic cancer cell capture and release. Journal of Materials Chemistry B, 2020, 8 (33), 7511-7520.
Liwei Yang, He Sun, Wenning Jiang, Ting Xu, Bing Song, Ruilian Peng, Lulu Han*, Lingyun Jia. A chemical method for specific capture of circulating tumor cells using label-free polyphenol-functionalized films. Chemistry of Materials, 2018, 30, 4372-4382.
Liwei Yang, Lulu Han*, QiLiu, Yige Xu, Lingyun Jia*. Galloyl groups-regulated fibrinogen conformation: Understanding antiplatelet adhesion on tannic acid coating. Acta Biomaterialia, 2017, 64, 187-199.
Liwei Yang, Lulu Han*, Lingyun Jia*. A Novel Platelet-Repellent Polyphenolic Surface and Its Micropattern for Platelet Adhesion Detection. ACS Applied Materials & Interfaces. 2016, 8 (40): 26570-26577.
Lulu Han, Zhengwei Mao*, Jindan Wu, Yang Guo, Tanchen Ren, Changyou Gao*. Directional Cell Migration through Cell-Cell Interaction on Polyelectrolyte Multilayers with Swelling Gradients. Biomaterials. 2013, 34 (4): 975-984.