当前位置: X-MOL首页全球导师 国内导师 › 张志超

个人简介

教育经历 1999.32002.7 大连理工大学生物化工博士 1989.91996.7 白求恩医科大学临床医学硕士 工作经历 2015.1至今 大连理工大学教授 2005.12014.12 大连理工大学副教授 2002.82005.1 大连理工大学讲师 1996.81999.3 大连铁路医院医师

研究领域

利用化学小分子,尤其是蛋白蛋白相互作用抑制剂分子,研究肿瘤靶标蛋白的功能,意义,和动态修饰对肿瘤靶标性质的改变。具体包括凋亡、自噬等过程中的关键靶标的确认,靶向分子的鉴定,利用小分子描绘肿瘤靶标蛋白的信号转导通路和分子机制。 利用抑制剂分子,在蛋白质组水平确认肿瘤靶标和研究肿瘤信号转导通路。 基于结构和片段的肿瘤蛋白质相互作用抑制剂的分子设计、合成、和生物学活性研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

张志超.DNA Double Helix Unwinding Triggers Transcription Block-Dependent Apoptosis: A Semiquantitative...[J],CHEMICAL RESEARCH IN TOXICOLOGY,2021,22(3):483-491 王紫千.Targeting the allosteric pathway that interconnect the core-functional scaffold and the distal ph...[J],Journal of medicinal chemistry,2021,63(1111):13733-13744 张志超.A “three-in-one” multi-functional probe for Bcl-2/Mcl-1 profiling and visualizing in situ.[J],ChemBioChem,2021,22:326-329 Zhu Junjie,Wang Ziqian,Guo Zongwei,Zhang Xiaodong,Song Ting,Guo Yafei,Ji Tong,Zhang Zhichao.Structure-based design, synthesis, and evaluation of Bcl-2/Mcl-1 dual inhibitors[J],Archiv der Pharmazie,2020,353(5):e2000005 张志超.Affinity-based probe reveal Bim negatively regulates the chaperone functions of Hsp70, a non-Bcl-...[A],2019,(13 Supplement): 79:2754- 郭宗伟,宋婷,薛祖光,刘朋,张民行,张肖冬,张志超.Using CETSA assay and a mathematical mode lto reveal dual Bcl-2/Mcl-1 inhibition and on-target me...[J],European Journal of Pharmaceutical Sciences,2019,142(15) Zhang, Han,Qiu, Jieshan,Tian, Dongxu,Zhao, Zongbin,Liu, Xuguang,Hou, Ya-Nan,Tang, Yujiao,Liang, Jingjing,Zhang, Zhichao,Wang, Xuzhen.Cobalt nitride nanoparticles embedded in porous carbon nanosheet arrays propelling polysulfides...[J],ENERGY STORAGE MATERIALS,2019,21:210-218 Wang, Ziqian,Zhang, Zhichao,Song, Ting,Guo, Zongwei.Affinity-based probe reveal Bim negatively regulates the chaperone functions of Hsp70, a non-Bc...[J],CANCER RESEARCH,2019,79(13) Ma, He,We, Yang,Jian, Kaili,Pan, Lujun,Liu, Kai,Zhang, Xinping,Zhang, Zhichao,Wang, Yu,Wang, Guang,Liu, Feifei,Cui, Ruixue,Huang, Cuiying,Wang, Meng.Infrared micro-detectors with high sensitivity and high response speed using VO2-coated helical...[J],JOURNAL OF MATERIALS CHEMISTRY C,2019,7(39):12095-12103 宋婷,刘宇博,张志超.磷酸化Bcl-2蛋白的BH3模拟分子——基于细胞模型的定向筛选和构效关系研究[A],2013,1 Zhang, Han,Zhao, Zongbin,Hou, Ya-Nan,Tang, Yongchao,Liang, Jingjing,Liu, Xuguang,Zhang, Zhichao,Wang, Xuzhen,Qiu, Jieshan.Highly stable lithium-sulfur batteries based on p-n heterojunctions embedded on hollow sheath c...[J],JOURNAL OF MATERIALS CHEMISTRY A,2019,7(15):9230-9240 Wang Peiran,Zhang Zhichao.Identification of the Apoptosis and Autophagy Bi-functional Proteins[J],Molecular informatics,2019 宋婷,王沛然,于晓燕,王安辉,柴高波,范玉丹,张志超.Systems analysis of phosphorylationregulated Bcl-2 interactions establishes a model to reconcile ...[J],British Journal of Pharmacology,2018,176:491-504 刘璐,张志超.线性短模体:介导蛋白质相互作用的新模块[J],生物化学与生物物理进展,2017,44(02):129-138 Wang, Ziqian,Xu, Wenjie,Song, Ting,Guo, Zongwei,Liu, Lu,Fan, Yudan,Wang, Anhui,Zhang, Zhichao.Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxyli...[J],ARCHIV DER PHARMAZIE,2017,350(1) Song, Ting,Wang, Ziqian,Ji, Fangling,Feng, Yingang,Fan, Yudan,Chai, Gaobo,Li, Xiangqian,Li, Zhiqiang,Zhang, Zhichao.Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3...[J],ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(46):14248-14254 Song, Ting,Wang, Ziqian,Zhang, Zhichao.Substituted indole Mcl-1 inhibitors: a patent evaluation (WO2015148854A1)[J],EXPERT OPINION ON THERAPEUTIC PATENTS,2016,26(11):1227-1238 Wang, Anhui,Song, Ting,Wang, Ziqian,Liu, Yubo,Fan, Yudan,Zhang, Yahui,Zhang, Zhichao.Mechanism of Mcl-1 Conformational Regulation Upon Small Molecule Binding Revealed by Molecular ...[J],CHEMICAL BIOLOGY & DRUG DESIGN,2016,87(4):551-561 Song, Ting,Chai, Gaobo,Liu, Yubo,Yu, Xiaoyan,Wang, Ziqian,Zhang, Zhichao.Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mime...[J],BRITISH JOURNAL OF PHARMACOLOGY,2016,173(3):471-483 宋婷,张志超.Bcl-2/MDM2 Dual Inhibitors Based On Universal Pyramid-Like alpha-Helical Mimetics[A],2016,59(7):3152-3162 Song, Ting,Xie, Mingzhou,Chen, Qingbin,Yu, Xiaoyan,Sheng, Hongkun,Zhang, Zhichao,Chai, Gaobo,Liu, Yubo.Mechanism of synergy of BH3 mimetics and paclitaxel in chronic myeloid leukemia cells: Mcl-1 in...[J],EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2015,70:64-71 Song, Ting,Yu, Xiaoyan,Liu, Yubo,Li, Xiangqian,Chai, Gaobo,Zhang, Zhichao.Discovery of a Small-Molecule pBcl-2 Inhibitor that Overcomes pBcl-2-Mediated Resistance to Apo...[J],CHEMBIOCHEM,2015,16(5):757-765 Liu, Yubo,Sheng, Hongkun,Yu, Xiaoyan,Zhang, Zhichao,Xie, Mingzhou,Song, Ting.A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to a...[J],PIGMENT CELL & MELANOMA RESEARCH,2015,28(2):161-170 Li, Xiangqian,Liang, Xiaomeng,Song, Ting,Su, Pengchen,Zhang, Zhichao.Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene deriva...[J],BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(21):5738-5746 Huang, Xing,Wang, Chuang,Li, Song,Liu, Yubo,Zhang, Zhichao.Highly Sensitive Visualization of Inorganic Mercury in Mouse Neurons Using a Fluorescent Probe[J],JOURNAL OF FLUORESCENCE,2014,24(4):1313-1317 Li, Xiangqian,Wang, Ziqian,Feng, Yingang,Song, Ting,Su, Pengchen,Chen, Chengbin,Chai, Gaobo,Yang, Ying,Zhang, Zhichao.Two-Face, Two-Turn alpha-Helix Mimetics Based on a Cross-Acridine Scaffold: Analogues of the Bi...[J],CHEMBIOCHEM,2014,15(9):1280-1285 Song, Ting,Li, Xiangqian,Yang, Ying,Wu, Guiye,Xie, Shenghui,Su, Pengchen,Feng, Yingang,Zhang, Zhichao.3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-...[J],BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(1):663-664 张志超,宋婷.Corrigendum to ‘‘3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b]pyrrole-9-carbonitrile (S1) derivat...[J],Bioorg. Med. Chem,2014,22(1):663-664 Song, Ting,Chen, Qingbin,Li, Xiangqian,Chai, Gaobo,Zhang, Zhichao.3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) Based Molecules as Potent...[J],JOURNAL OF MEDICINAL CHEMISTRY,2013,56(22):9366-9367 Liu, Yubo,Zhang, Zhichao.RESISTANCE TO BH3 MIMETIC S1 IN NON-SMALL CELL LUNG CANCER CELLS THAT PHOSPHORYLATE BIM THROUGH...[J],JOURNAL OF THORACIC ONCOLOGY,2013,8:S1061-S1061 Liu, Yubo,Zhang, Zhichao,Song, Ting,Liang, Furong,Xie, Mingzhou,Sheng, Hongkun.RESISTANCE TO BH3 MIMETIC S1 IN SCLC CELLS THAT UP-REGULATE AND PHOSPHORYLATE BCL-2 THROUGH ERK...[J],JOURNAL OF THORACIC ONCOLOGY,2013,8(7):S767-S767 李祥乾,宋婷,陈清斌,张志超.蒽醌类双面α-螺旋模拟物的设计、合成和活性分析[A],2013,239-239 Song, Ting,Liang, Furong,Sheng, Hongkun,Xie, Mingzhou,Zhang, Zhichao,Liu, Yubo.S1 kills MCF-7/ADR cells more than MCF-7 cells: A protective mechanism of endoplasmic reticulum...[J],BIOMEDICINE & PHARMACOTHERAPY,2013,67(8):731-736 Zhang, Zhichao,Su, Pengchen,Xie, Shenghui,Zhao, Yan,Song, Ting,Liu, Yubo,Li, Xiangqian.Study of Binding Thermodynamics in the Optimization of BH3 Mimetics[J],CHEMICAL BIOLOGY & DRUG DESIGN,2013,82(4):394-400 Song, Ting,Xue, Zuguang,Zhang, Zhichao,Shen, Xiaoyun,Li, Xiangqian.Pan-BH3 Mimetic S1 Exhibits Broad-Spectrum Antitumour Effects by Cooperation between Bax and Ba...[J],BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2013,113(3):145-151 Liu, Yubo,Li, Zhiqiang,Song, Ting,Xue, Zuguang,Zhang, Zhichao.Mechanisms of anti-leukemic activity of the Bcl-2 homology domain-3 mimetic S1[J],BIOMEDICINE & PHARMACOTHERAPY,2013,67(7):583-591 Zhang, Z.,Liu, Y.,Song, T.,Xue, Z.,Shen, X.,Liang, F.,Zhao, Y.,Li, Z.,Sheng, H..An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan...[J],BRITISH JOURNAL OF CANCER,2013,108(9):1870-1878 Zhang, Zhichao,Chen, Hongbo,Shen, Xiaoyun,Zhao, Yan,Liang, Xiaomeng,Wu, Zhiyong,Song, Ting,Li, Xiangqian,Liu, Chengwu.Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthio...[J],EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,60:410-420 Song, Ting,Feng, Yingang,Zhang, Zhichao,Li, Xiangqian,Chang, Xilong,Liang, Xiaomeng,Zhao, Yan,Wu, Guiye,Xie, Shenghui,Su, Pengchen,Wu, Zhiyong.3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-...[J],BIOORGANIC & MEDICINAL CHEMISTRY,2013,21(1):11-20 张志超,宋婷.Design and application of a rigid quinazolone scaffold based on two-face Bim a-helix mimicking.[J],European Journal of Medicinal Chemistry, 2013, 711-718,2013,69(65):711-718

推荐链接
down
wechat
bug