个人简介
郑楷博士,深圳大学助理教授,深圳市后备人才,广东省生物医学工程学会健康工程分会委员。2014年获暨南大学理学博士学位,随后加入深圳大学从事博士后研究工作,2017年12月被深圳大学聘为助理教授,2018年被评为硕士生导师。近年来主持有国家青年科学基金,博士后基金,省医学基金等。工作主要聚焦于抗肿瘤与抗感染创新药物的研发,探讨细胞自噬-溶酶体途径在细胞死亡中的作用,在Autophagy、Theranostics等杂志发表SCI论文近40篇,并担任多个SCI杂志特邀审稿人。
研究领域
1. 细胞自噬-溶酶体与细胞死亡
2. 抗肿瘤与抗病毒创新药物
3. 病毒感染的分子机制
1.广东省医学科研基金,A2019044,选择性细胞自噬调控细胞周期阻滞在食管癌耐药中的作用,2019.07-2021.06,在研,主持;
2.国家自然科学基金青年基金,81603341,皂苷类单体抑制自噬体-溶酶体融合过程在食管癌治疗中的作用与分子机制,2017/01-2019/12,在研,主持;
近期论文
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1) Ma J, Hu X, Liao C, Xiao H, Zhu Q, Li Y, Liu Z, Tao A, He Z, Xu C*, Zheng K*. Gypenoside L inhibits proliferation of liver and esophageal cancer cells by inducing senescence. Molecules, 2019, 24:1054.
2) Zheng K*, He Z, Kitazato K, Wang Y. Selective Autophagy Regulates Cell Cycle in Cancer Therapy. Theranostics, 2019, 9(1):104-125.
3) Zheng K#,*, Jiang Y#, Liao C, Hu X, Li Y, Zeng Y, Zhang J, Wu X, Wu H, Liu L, Wang Y*, He Z*. NOX2-mediated TFEB activation and vacuolization regulate lysosome-associated cell death induced by Gypenoside L, a saponin isolated from Gynostemma pentaphyllum. Journal of Agricultural and Food Chemistry, 2017, 2017, 65:6625-6637.
4) Zheng K, Li Y, Wang S, Wang X, Liao C, Hu X, Fan L, Kang Q, Zeng Y, Wu X, Wu H, Zhang J*, Wang Y*, He Z*. Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint. Autophagy. 2016, 12: 1593-1613
5) Zheng K#, Liao C#, Li Y#, Fan X, Fan L, Xu H, Kang Q, Zeng Y, Wu X, Wu H, Liu L, Xiao X, Zhang J*, Wang Y*, He Z*. Gypenoside L, isolated from Gynostemma pentaphyllum, induces cytoplasmic vacuolation death in Hepatocellular Carcinoma Cell through ROS-mediated unfolded protein response. Journal of Agricultural and Food Chemistry, 2016, 64:1702-1711