胡命豪 - 深圳大学 - 医学部药学院

个人简介

2008.09–2012.06，中山大学药学院，药学专业，获学士学位 2012.09–2017.06，中山大学药学院，药物化学专业，获博士学位 2017.07–2021.01，深圳大学医学部药学院，助理教授 2021.01–至今，深圳大学医学部药学院，长聘副教授

研究领域

（1）开发具有新型化学骨架、具有较大成药潜力的先导化合物（2）开发靶向G-四链体结构的功能性小分子化合物（3）探究G-四链体小分子配体在难治性肿瘤、耐药性肿瘤上的应用。

近期论文

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Wang, X.#; Yu, B.-Y.#; Lin, J.-H.; Yan, Y.; Hu, M.-H.*Development of a near-infrared fluorescent ligand that visualizes and stabilizes G-quadruplexes by decorating the triphenylamine scaffold. Sens. Actuators B Chem., 2021, 330, 129391. Hu, M.-H.* Pyrazine-based G-quadruplex fluorescent probes: transformation between aggregation-induced emission and disaggregation-induced emission via slight variations in structures. Sens. Actuators B Chem., 2021, 328,128990. Hu, M.-H.*; Yu, B.-Y.; Wang, X.; Jin, G.Drug-like biimidazole derivatives dually target c-MYC/BCL-2 G-quadruplexes and inhibit acute myeloid leukemia. Bioorg. Chem., 2020, 104, 104264. Hu, M.-H.*; Chen, X. New fluorescent light-up quinoxalines differentiate between parallel and nonparallel G-quadruplex topologies using different excitation/emission channels. Chem. Commun., 2020, 56, 4168–4171. Wu, T.-Y.; Huang, Q.; Huang, Z.-S.; Hu, M.-H.*; Tan, J.-H.*A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg. Chem.,2020, 99, 103866. Hu, M.-H.*; Lin, X.-T.; Liu, B; Tan, J.-H. Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere. Eur. J. Med. Chem., 2020, 186, 111891. Hu, M.-H.*; Wu, T.-Y.; Huang, Q.; Jin, G.*New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription. Nucleic Acids Res., 2019, 47, 10529–10542. Hu, M.-H.*; Chen, X; Tan, J.-H. Development of a multitasking fluorescent probe for differentiating G-quadruplex structures. Dyes Pigm., 2019, 170, 107560. Hu, M.-H.#; Zhou, J.#; Luo, W.-H.; Chen, S.-B.; Huang, Z.-S.; Wu, R.*; Tan, J.-H.* Development of a smart fluorescent sensor that specifically recognizes the c-MYC G-quadruplex. Anal. Chem., 2019, 91, 2480–2487. Hu, M.-H.#; Wang, Y.-Q.#; Yu, Z-Y; Hu, L-N; Ou, T.-M.; Chen, S.-B.*; Tan, J.-H.* Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex. J. Med. Chem., 2018, 61, 2447–2459. Wang, Y.-Q.#; Hu, M.-H.#; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.* Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA. Sens. Actuators B Chem., 2018, 266, 187–194. Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.*Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Res., 2017, 45, 1606–1618. Hu, M.-H.#; Guo, R.-J.#; Chen, S.-B.; Huang, Z.-S.;Tan, J.-H.* Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes. Dyes Pigm., 2017, 137, 191–199 Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole. Biosens. Bioelectron., 2016, 83, 77–84. Hu, M.-H.; Chen, S.-B.; Guo, R.-J.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.*Development of a highly sensitive fluorescent light-up probe for G-quadruplexes. Analyst, 2015, 140, 4616–4625. Hu, M.-H.; Chen, X.; Chen, S.-B.; Ou, T.-M.; Yao, M.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.* A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology. Sci. Rep., 2015, 5, 17202.