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个人简介

2003年本科毕业于上海交通大学生物医学工程系后,直接攻读博士并于2009年获得工学博士学位。2009年12月进入深圳大学生物医学工程系。现为硕士生导师,深圳市高层次专业人才后备级人才。近年来主持国家自然科学基金1项,广东省项目2项,中国博士后科学基金1项,深圳市项目2项。以第一作者或通讯作者发表论文10余篇。目前主要从事医学超声微泡治疗领域的研究,包括靶向输送药物、肿瘤治疗等。

研究领域

医学超声药物递送和神经元调控

1.主持项目 1. 广东省医学科学技术研究基金项目,A2017289,超声联合微泡输送声敏剂入脑胶质瘤的参数研究,2017.07-2019.06,主持。 2. 深圳市战略新兴产业发展专项资金基础研究项目, JCYJ20160520175319943,超声联合微泡输送声敏剂入脑胶质瘤的声动力治疗研究,2017.02-2019.02,主持。 3. 广东省普通高校特色创新(自然科学)项目,2016KTSCX123,超声激励载紫杉醇脂质体微泡开放血脑屏障治疗脑胶质瘤的研究,2017.01-2018.12,主持。 4. 深圳市战略新兴产业发展专项资金基础研究项目,JCYJ20140828163634004,低频聚焦超声联合微泡递送AD多肽药物安全入脑的基础研究,2014.12-2016.12,主持。 5. 国家自然科学基金青年基金,81101171,低频超声微泡介导NGF脂质体修复受损胆碱能神经元的研究,2012.01-2012.12,主持。 6. 中国博士后科学基金面上项目,20100470903,超声微泡开放血脑屏障介导神经生长因子入脑的研究,2010.06-2011.12,主持。 2. 参与项目  (1)国家自然科学基金-重大科研仪器研制项目“基于声辐射力-洛伦兹力的超声-磁电双模成像方法与仪器研制”(编号61427806),2015年1月-2019年12月。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zhaoke Pi, Yongpeng Huang, Yuanyuan Shen*, Xiaojun Zeng, Yaxin Hu, Tie Chen, Chenyang Li, Hao Yu, Siping Chen, Xin Chen*, Sonodynamic therapy on intracranial glioblastoma xenografts using sinoporphyrin sodium delivered by ultrasound with microbubbles, Annals of Biomedical Engineering, 47(2): 549-562, 2019 . 2. Yuanyuan Shen, Zhaoke Pi, Fei Yan*, Chih-Kuang Yeh, Xiaojun Zeng, Xianfen Diao, Yaxin Hu, Siping Chen, Xin Chen*, Hairong Zheng, Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma xenografts, International Journal of Nanomedicine, 12: 5613-5629, 2017. 3. Haoming Lin, Xinyu Zhang, Yuanyuan Shen*, Yi Zheng, Yanrong Guo, Ying Zhu, Xianfen Diao, Tianfu Wang, Siping Chen, Xin Chen*, Model-dependent and model-independent approaches for evaluating hepatic fibrosis in rat liver using shearwave dispersion ultrasound vibrometry, Medical Engineering and Physics, 39: 66-72, 2016. 4. Haoming Lin#, Yuanyuan Shen#, Xin Chen*, Ying Zhu, Yi Zheng, Xinyu Zhang, Yanrong Guo, Tianfu Wang, Siping Chen*, Viscoelastic properties of normal rat liver measured by ultrasound elastography: comparison with oscillatory rheometry. Biorheology, 53, 5-6: 193-207, 2016. 5. Yuanyuan Shen, Jinxuan Guo, Gaoshu Chen, Chien Ting Chin, Xin Chen, Jian Chen, Feng Wang, Shiguo Chen, Guo Dan*, Delivery of liposomes with different sizes to mice brain after sonication by focused ultrasound in the presence of microbubbles, Ultrasound in Medicine and Biology, 42(7): 1499-1511, 2016. 6. Ying Zhu, Xin Chen, Xinyu Zhang, Siping Chen, Yuanyuan Shen*, Liang Song, Modeling the mechanical properties of liver fibrosis in rats. Journal of Biomechanics, 49:1461-1467, 2016. 7. Hao Yu, Zhongshi Lin, Liang Xu, Dalong Liu, Yuanyuan Shen*, Theoretical study of microbubble dynamics in sonoporation, Ultrasonics, 61: 136-144, 2015. 8. Yuanyuan Shen, Aili Zhang, Jinxuan Guo, Guo Dan, Siping Chen and Hao Yu,Fluorescence imaging of Evans blue extravasation into mouse brain induced by low frequency ultrasound with microbubble, Bio-Medical Materials and Engineering, 2014, 24(6): 2831-2838. 9. Yuanyuan Shen, Tianfu Wang, Chien Ting Chin, Xianfen Diao and Siping Chen, Interaction Between Microbubble and Elastic Microvessel in Low Frequency Ultrasound Field Using Finite Element Method, Chinese Science Bulletin, 58(3): 291-298, 2013. 专著 Yi Zheng. Xin Chen, Aiping Yao, Haoming Lin, Yuanyuan Shen, Yin Zhu, Minhua Lu, Tianfu Wang and Shiping Chen,Wave Propogation/ Book 2 (Chapter 1 Shear Wave Propagation in Soft Tissue and Ultrasound Vibrometry),Intech Publisher,2013  《小儿超声诊断学(第2版)》,人民卫生出版社,2013年7月,编者(第一章第3、5节)

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