白凤 - 深圳大学 - 医学部基础医学院

个人简介

白凤 (FENG BAI), 1988年获兰州大学临床医学专业学士学位, 1994年获兰州大学医学部病理学硕士学位， 2000年获日本九州大学博士学位. 1988-1995年兰州大学医学部病理教研室，助教.讲师. 1995-2000日本九州大学医学部访问研究员，博士研究生, 2000-2010美国北卡罗来纳大学 (University of North Carolina at Chapel Hill) 博士后，副研究员，2011-2018美国迈阿密大学 (University of Miami) 研究科学家. 2018年被深圳大学聘为教授。白凤教授拥有独特的肿瘤病理研究背景, 长期从事人类疾病及基因工程小鼠分子病理研究。建立了三十余种基因敲除小鼠的两万余组织脏器标本库，建立了多种基因敲除小鼠肿瘤模型, 乳腺癌，前列腺癌，淋巴瘤，肺癌，甲状腺癌，垂体瘤，胰岛细胞瘤，先天性耳聋和多囊肾等。首次证明p18Ink4c受到GATA3调控,抑制乳腺癌。BRCA1功能缺失使雌激素受体阳性乳腺癌变为三阴乳腺癌。p18Ink4c完全依赖Cdk4抑制内分泌细胞分裂，增殖，和癌变。p18Ink4c和 Pten 或 Men1协同抑制内分泌肿瘤,淋巴瘤,前列腺癌,及非小细胞肺癌的发生和发展。敲除p19Ink4d除了引发多种肿瘤外, 也造成先天性耳聋. 而抑制CDK4功能可完全治愈p19基因缺失所引起的先天性耳聋。曾主持和承担美国多项联邦，州和大学基金基金项目。发表SCI国际期刊杂志论文36篇。包括Cancer Cell, Molecular Cell, Oncogene等。。第一作者发表论文最高影响因子25.3分。论文被引用2000多次，H 指数22.

研究领域

研究方向：以分子病理为技术途径，以病人标本和基因敲除小鼠为对象，研究细胞周期的体内调控，肿瘤干细胞的更新，肿瘤的分子和病理分型及靶向治疗

近期论文

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论文 (#表示通讯作者；*共享第一作者) 1. Wang C, Bai F#, Zhang LH, Scott A, Li E, Pei XH. (2018) Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression. Breast Cancer Research. 20(1);74:1-17. 2. Benitez A, Liu W, Palovcak A, Wang G, Moon J, An K, Kim A, Zheng K, Zhang Y, Bai F, Mazin AV, Pei XH, Yuan F, Zhang Y. (2018) FANCA promotes DNA double strand break repair by catalyzing single-strand annealing and strand exchange. Molecular Cell. 16;71(4):621-628. 3. Scott A, Bai F#, Chan HL, Liu S, Slingerland JM, Robbins DJ, Capobianco AJ, Pei XH. (2017) p16 loss rescues functional decline of Brcac1-deficient mammary stem cells. Cell Cycle. 6(8):759-764. 4. Ma Q*, Grati M*, Bai F*, Pei J, Pei XH, Liu X. (2016) Rescue from early onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d. Cell Death and Disease. 10;7:e2131. *equal contribution. 5. Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou, CM, Livingstone AS, Robbins DJ, Capobianco AJ, Pei XH. (2014) BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development. Cancer Research. 74(21):6161-6172. 6. Bai F, Chan HL, Smith MD, Kiyokawa H, Pei XH. (2014) p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. Molecular and Cellular Biology. 34(12): 2121-2134. (Cover article). 7. Bai F, Smith MD, Chan HL, Pei XH. (2013) Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation. Oncogene. 30;32(22): 2715-2725. Featured Article. Commentary in Oncogene: BRCA1 mutations and luminal-basal transformation. Ng T, Irshad S, Stebbing J. 2013 May 30;32(22):2712-2714. 8. Pei XH, Bai F, Li Z, Smith MD, Whitewolf G, Jin R, and Xiong Y. (2011) Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Research. 71, 2969-2977. 9. Pei XH*, Bai F*, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y. (2009) CDK inhibitor p18INK4c is a downstream target of GATA3 and controls mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell, 15, 389-401. *equal contribution. 10. Pei XH*, Bai F*, Smith MD, Xiong Y. (2007) p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Research. 67, 3162-3170. *equal contribution.