蔡毅 - 深圳大学 - 医学部基础医学院

个人简介

蔡毅，中山大学博士，麻省大学医学院博士后。2017年11月入职深圳大学,新锐研究生导师。研究相关成果发表在Journal of Clinical Investigation，Journal of Experimental Medicine，PLOS Pathgens，mBio等杂志，发明专利11项，转化1项，首个靶向宿主治疗结核病药物SASP进入临床III期试验。主持国家自然科学3项、深圳市学科布局项目1项、重点项目1项、孔雀启动项目1项、深圳市自由探索项目1项。深圳市孔雀C类人才，后备级人才，南山区领航人才C类。

研究领域

1）结核发生发展与细胞异质性 2）细菌与宿主相互作用的机制 3）抗结核药物筛选及其作用机制 4）结核感染宿主免疫保护机制。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Cai Y, Fan J, Sun S, Wang F, Yang K, Li G, Pang Y. Interspecific interaction between Spodoptera exigua multiple nucleopolyhedrovirus and Microplitis bicoloratus (Hymenoptera: Braconidae: Microgastrina) in Spodoptera exigua (Lepidoptera: Noctuidae) larvae. J Econ Entomol. 2012 Oct;105(5):1503-8. doi: 10.1603/ec12077. PubMed PMID: 23156143. Cai Y, Long Z, Qiu J, Yuan M, Li G, Yang K. An ac34 deletion mutant of Autographa californica nucleopolyhedrovirus exhibits delayed late gene expression and a lack of virulence in vivo. J Virol. 2012 Oct;86(19):10432-43. doi: 10.1128/JVI.00779-12. Epub 2012 Jul 11. PubMed PMID: 22787232; PubMed Central PMCID: PMC3457258. Cai Y, Yang Q, Tang Y, Zhang M, Liu H, Zhang G, Deng Q, Huang J, Gao Z, Zhou B, Feng CG, Chen X. Increased complement C1q level marks active disease in human tuberculosis. PLoS One. 2014;9(3):e92340. doi: 10.1371/journal.pone.0092340. eCollection 2014. PubMed PMID: 24647646; PubMed Central PMCID: PMC3960215. Yang Q, Cai Y, Zhao W, Wu F, Zhang M, Luo K, Zhang Y, Liu H, Zhou B, Kornfeld H, Chen X. IP-10 and MIG are compartmentalized at the site of disease during pleural and meningeal tuberculosis and are decreased after antituberculosis treatment. Clin Vaccine Immunol. 2014 Dec;21(12):1635-44. doi: 10.1128/CVI.00499-14. Epub 2014 Oct 1. PubMed PMID: 25274803; PubMed Central PMCID: PMC4248780. Yang Q, Xu Q, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X. Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells. Sci Rep. 2015 Dec 8;5:17918. doi: 10.1038/srep17918. PubMed PMID: 26643453; PubMed Central PMCID: PMC4672319. Cai Y, Yang Q, Liao M, Wang H, Zhang C, Nambi S, Wang W, Zhang M, Wu J, Deng G, Deng Q, Liu H, Zhou B, Jin Q, Feng CG, Sassetti CM, Wang F, Chen X. xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation. Oncotarget. 2016 May 24;7(21):31001-13. doi: 10.18632/oncotarget.9052. PubMed PMID: 27129162; PubMed Central PMCID: PMC5058734. Wu C, Deng Z, Long Z, Cai Y, Ying Z, Yin H, Yuan M, Clem RJ, Yang K, Pang Y. Generating a host range-expanded recombinant baculovirus. Sci Rep. 2016 Jun 20;6:28072. doi: 10.1038/srep28072. PubMed PMID: 27321273; PubMed Central PMCID: PMC4913269. Zhang G, Liu X, Wang W, Cai Y, Li S, Chen Q, Liao M, Zhang M, Zeng G, Zhou B, Feng CG, Chen X. Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages. Cell Cycle. 2016 Sep 16;15(18):2527-38. doi: 10.1080/15384101.2016.1215386. Epub 2016 Aug 5. PubMed PMID: 27494776; PubMed Central PMCID: PMC5026815. Dai Y, Wen Z, Ye T, Deng G, Zhang M, Deng Q, Yang Q, Shan W, Kornfeld H, Cai Y, Chen X. Empirical treatment with non-anti-tuberculosis antibiotics decreased microbiological detection in cervical tuberculous lymphadenitis. Diagn Microbiol Infect Dis. 2018 Nov;92(3):245-249. doi: 10.1016/j.diagmicrobio.2018.06.008. Epub 2018 Jun 20. PubMed PMID: 30076042. Tang J, Cai Y, Liang J, Tan Z, Tang X, Zhang C, Cheng L, Zhou J, Wang H, Yam WC, Chen X, Wang H, Chen Z. In vivo electroporation of a codon-optimized BER(opt) DNA vaccine protects mice from pathogenic Mycobacterium tuberculosis aerosol challenge. Tuberculosis (Edinb). 2018 Dec;113:65-75. doi: 10.1016/j.tube.2018.07.003. Epub 2018 Jul 10. PubMed PMID: 30514515. Qiu J, Tang Z, Cai Y, Wu W, Yuan M, Yang K. The Autographa californica Multiple Nucleopolyhedrovirus ac51 Gene Is Required for Efficient Nuclear Egress of Nucleocapsids and Is Essential for In Vivo Virulence. J Virol. 2019 Feb 1;93(3). doi: 10.1128/JVI.01923-18. Print 2019 Feb 1. PubMed PMID: 30429334; PubMed Central PMCID: PMC6340016. Zhu CZ, Hu BY, Liu JW, Cai Y, Chen XC, Qin DP, Cheng YX, Zhang ZD. Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora. Molecules. 2019 Apr 15;24(8). doi: 10.3390/molecules24081475. PubMed PMID: 30991677; PubMed Central PMCID: PMC6515556. Liu X, Cai Y, Wang Y, Xu S, Ji K, Choi K. Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish. Ecotoxicol Environ Saf. 2019 Apr 15;170:25-32. doi: 10.1016/j.ecoenv.2018.11.058. Epub 2018 Dec 1. PubMed PMID: 30508752. Yang Q, Liao M, Wang W, Zhang M, Chen Q, Guo J, Peng B, Huang J, Liu H, Yahagi A, Xu X, Ishihara K, Cooper A, Chen X, Cai Y. CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. mBio. 2019 Aug 27;10(4). doi: 10.1128/mBio.01949-19. PubMed PMID: 31455656; PubMed Central PMCID: PMC6712401. Zhu C, Cai Y, Zhu J, Zhang L, Xing A, Pan L, Jia H, Mo S, Feng CG, Shen H, Chen X, Zhang Z. Histone deacetylase inhibitors impair the host immune response against Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2019 Sep;118:101861. doi: 10.1016/j.tube.2019.101861. Epub 2019 Aug 27. PubMed PMID: 31526947. Dai Y, Shan W, Yang Q, Guo J, Zhai R, Tang X, Tang L, Tan Y, Cai Y, Chen X. Biomarkers of iron metabolism facilitate clinical diagnosis in Mycobacterium tuberculosis infection. Thorax. 2019 Dec;74(12):1161-1167. doi: 10.1136/thoraxjnl-2018-212557. Epub 2019 Oct 14. PubMed PMID: 31611342; PubMed Central PMCID: PMC6902069. Dai Y, Cai Y, Wang X, Zhu J, Liu X, Liu H, Li L, Zhang Y, Liu S, Wen Z, Feng CG, Chen X, Tang X. Autoantibody-Mediated Erythrophagocytosis Increases Tuberculosis Susceptibility in HIV Patients. mBio. 2020 Feb 25;11(1). doi: 10.1128/mBio.03246-19. PubMed PMID: 32098821; PubMed Central PMCID: PMC7042700. Cai Y, Dai Y, Wang Y, Yang Q, Guo J, Wei C, Chen W, Huang H, Zhu J, Zhang C, Zheng W, Wen Z, Liu H, Zhang M, Xing S, Jin Q, Feng CG, Chen X. Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis. EBioMedicine. 2020 Mar;53:102686. doi: 10.1016/j.ebiom.2020.102686. Epub 2020 Feb 27. PubMed PMID: 32114394; PubMed Central PMCID: PMC7047188. Wang W, Deng G, Zhang G, Yu Z, Yang F, Chen J, Cai Y, Werz O, Chen X. Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population. Cytokine. 2020 Mar;127:154956. doi: 10.1016/j.cyto.2019.154956. Epub 2019 Dec 18. PubMed PMID: 31864094. Dai Y, Cai Y, Wang X, Zhu J, Liu X, Liu H, Li L, Zhang Y, Liu S, Wen Z, Feng CG, Chen X, Tang X. Erratum for Dai et al., "Autoantibody-Mediated Erythrophagocytosis Increases Tuberculosis Susceptibility in HIV Patients". mBio. 2020 Mar 31;11(2). doi: 10.1128/mBio.00510-20. PubMed PMID: 32234816; PubMed Central PMCID: PMC7157773. Lin D, Liu L, Zhang M, Hu Y, Yang Q, Guo J, Guo Y, Dai Y, Xu Y, Cai Y, Chen X, Zhang Z, Huang K. Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients. Sci China Life Sci. 2020 Apr;63(4):606-609. doi: 10.1007/s11427-020-1668-5. Epub 2020 Mar 5. PubMed PMID: 32170625; PubMed Central PMCID: PMC7089461. Ouyang Q, Zhang K, Lin D, Feng CG, Cai Y, Chen X. Bazedoxifene Suppresses Intracellular Mycobacterium tuberculosis Growth by Enhancing Autophagy. mSphere. 2020 Apr 8;5(2). doi: 10.1128/mSphere.00124-20. PubMed PMID: 32269154; PubMed Central PMCID: PMC7142296. Wang W, Cai Y, Deng G, Yang Q, Tang P, Wu M, Yu Z, Yang F, Chen J, Werz O, Chen X. Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions. mSphere. 2020 Apr 22;5(2). doi: 10.1128/mSphere.00263-20. PubMed PMID: 32321821; PubMed Central PMCID: PMC7178550. Yang Q, Zhang M, Chen Q, Chen W, Wei C, Qiao K, Ye T, Deng G, Li J, Zhu J, Cai Y, Chen X, Ma L. Cutting Edge: Characterization of Human Tissue-Resident Memory T Cells at Different Infection Sites in Patients with Tuberculosis. J Immunol. 2020 May 1;204(9):2331-2336. doi: 10.4049/jimmunol.1901326. Epub 2020 Mar 30. PubMed PMID: 32229539; PubMed Central PMCID: PMC7167459. Hu Y, Wen Z, Liu S, Cai Y, Guo J, Xu Y, Lin D, Zhu J, Li D, Chen X. Ibrutinib suppresses intracellular mycobacterium tuberculosis growth by inducing macrophage autophagy. J Infect. 2020 Jun;80(6):e19-e26. doi: 10.1016/j.jinf.2020.03.003. Epub 2020 Mar 11. PubMed PMID: 32171871. Yang Q, Chen Q, Zhang M, Cai Y, Yang F, Zhang J, Deng G, Ye T, Deng Q, Li G, Zhang H, Yi Y, Huang RP, Chen X. Identification of eight-protein biosignature for diagnosis of tuberculosis. Thorax. 2020 Jul;75(7):576-583. doi: 10.1136/thoraxjnl-2018-213021. Epub 2020 Mar 22. PubMed PMID: 32201389; PubMed Central PMCID: PMC7361018. Liu X, Cai Y, Wang Y, Xu S, Ji K, Choi K. Corrigendum to "Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex dependent alterations of thyroid hormones in adult zebrafish" [Ecotoxicol. Environ. Saf. 170 (2019) 25-32]. Ecotoxicol Environ Saf. 2020 Sep 15;201:110867. doi: 10.1016/j.ecoenv.2020.110867. Epub 2020 Jun 12. PubMed PMID: 32540616. Lin D, Liu L, Zhang M, Hu Y, Yang Q, Guo J, Dai Y, Xu Y, Cai Y, Chen X, Huang K, Zhang Z. Evaluations of the serological test in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak. Eur J Clin Microbiol Infect Dis. 2020 Dec;39(12):2271-2277. doi: 10.1007/s10096-020-03978-6. Epub 2020 Jul 17. PubMed PMID: 32681308; PubMed Central PMCID: PMC7367508. Zhu C, Cai Y, Mo S, Zhu J, Wang W, Peng B, Guo J, Zhang Z, Chen X. NF-κB-mediated TET2-dependent TNF promoter demethylation drives Mtb-upregulation TNF expression in macrophages. Tuberculosis (Edinb). 2021 Jul;129:102108. doi: 10.1016/j.tube.2021.102108. Epub 2021 Jul 14. PubMed PMID: 34274886. Cai Y, Jaecklein E, Mackenzie JS, Papavinasasundaram K, Olive AJ, Chen X, Steyn AJC, Sassetti CM. Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase. PLoS Pathog. 2021 Jul;17(7):e1008911. doi: 10.1371/journal.ppat.1008911. eCollection 2021 Jul. PubMed PMID: 34320028; PubMed Central PMCID: PMC8351954. Fu L, Weng T, Sun F, Zhang P, Li H, Li Y, Yang Q, Cai Y, Zhang X, Liang H, Chen X, Wang Z, Liu L, Zhang W, Deng G. Insignificant difference in culture conversion between bedaquiline-containing and bedaquiline-free all-oral short regimens for multidrug-resistant tuberculosis. Int J Infect Dis. 2021 Oct;111:138-147. doi: 10.1016/j.ijid.2021.08.055. Epub 2021 Aug 25. PubMed PMID: 34454119. Ning Y, Cai Y, Dai Y, Li F, Mo S, Werz O, Chen X. Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy. Infect Immun. 2021 Oct 15;89(11):e0030621. doi: 10.1128/IAI.00306-21. Epub 2021 Aug 9. PubMed PMID: 34370506; PubMed Central PMCID: PMC8519288. Cai Y, Dai Y, Wang Y, Yang Q, Guo J, Wei C, Chen W, Huang H, Zhu J, Zhang C, Zheng W, Wen Z, Liu H, Zhang M, Xing S, Jin Q, Feng CG, Chen X. Corrigendum to 'single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis' [EBioMedicine 53 (2020) 102686]. EBioMedicine. 2022 Mar;77:103905. doi: 10.1016/j.ebiom.2022.103905. Epub 2022 Feb 25. PubMed PMID: 35228015; PubMed Central PMCID: PMC8889125. Cai Y, Wang Y, Shi C, Dai Y, Li F, Xu Y, Zhang P, Kong F, Deng G, Wen Z, Zhou Q, Kang BC, Singhal A, Yang Q, Feng CG, Chen X. Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion. J Exp Med. 2022 Mar 7;219(3). doi: 10.1084/jem.20211777. Epub 2022 Jan 21. PubMed PMID: 35061012; PubMed Central PMCID: PMC8789099. Chen X, Cai X, Chen Z, Wu J, Hao G, Luo Q, Liu S, Zhang J, Hu Y, Zhu G, Koester W, White AP, Cai Y, Wang Y. Mosaic Evolution of Beta-Barrel-Porin-Encoding Genes in Escherichia coli. Appl Environ Microbiol. 2022 Apr 12;88(7):e0006022. doi: 10.1128/aem.00060-22. Epub 2022 Mar 14. PubMed PMID: 35285711; PubMed Central PMCID: PMC9004372. Guo J, Zhang X, Chen X, Cai Y. Proteomics in Biomarker Discovery for Tuberculosis: Current Status and Future Perspectives. Front Microbiol. 2022;13:845229. doi: 10.3389/fmicb.2022.845229. eCollection 2022. Review. PubMed PMID: 35558124; PubMed Central PMCID: PMC9087271. Mo S, Liu X, Zhang K, Wang W, Cai Y, Ouyang Q, Zhu C, Lin D, Wan H, Li D, Wen Z, Chen X. Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin-dependent phagosome maturation. J Leukoc Biol. 2022 May;111(5):1021-1029. doi: 10.1002/JLB.4A0221-119RR. Epub 2021 Sep 17. PubMed PMID: 34533236. Wang W, Ning Y, Wang Y, Deng G, Pace S, Barth SA, Menge C, Zhang K, Dai Y, Cai Y, Chen X, Werz O. Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine. Front Immunol. 2022;13:849583. doi: 10.3389/fimmu.2022.849583. eCollection 2022. PubMed PMID: 35663935; PubMed Central PMCID: PMC9160237. Luo YS, Li W, Cai Y, Zhang J, Gui H, Zhang K, Cheng ZS. Genome-wide screening of sex-biased genetic variants potentially associated with COVID-19 hospitalization. Front Genet. 2022;13:1014191. doi: 10.3389/fgene.2022.1014191. eCollection 2022. PubMed PMID: 36353114; PubMed Central PMCID: PMC9637711. Mo S, Guo J, Ye T, Zhang X, Zeng J, Xu Y, Peng B, Dai Y, Xiao W, Zhang P, Deng G, Xu D, Long X, Cai Y, Chen X. Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis. mBio. 2022 Oct 26;13(5):e0200422. doi: 10.1128/mbio.02004-22. Epub 2022 Aug 24. PubMed PMID: 36000734; PubMed Central PMCID: PMC9600773. Daniel L, Bhattacharyya ND, Counoupas C, Cai Y, Chen X, Triccas JA, Britton WJ, Feng CG. Stromal structure remodeling by B lymphocytes limits T cell activation in lymph nodes of Mycobacterium tuberculosis-infected mice. J Clin Invest. 2022 Nov 1;132(21). doi: 10.1172/JCI157873. PubMed PMID: 36317628; PubMed Central PMCID: PMC9621141. Cootes TA, Bhattacharyya ND, Huang SSY, Daniel L, Bell-Anderson KS, Stifter SA, Chew T, Solon-Biet SM, Saraiva LR, Cai Y, Chen X, Simpson SJ, Feng CG. The quality of energy- and macronutrient-balanced diets regulates host susceptibility to influenza in mice. Cell Rep. 2022 Nov 15;41(7):111638. doi: 10.1016/j.celrep.2022.111638. PubMed PMID: 36384123. Wan H, Cai Y, Xiao L, Ling Y, Ge L, Mo S, Xie Q, Peng S, Zhou B, Zeng X, Chen X. JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation. Oxid Med Cell Longev. 2023;2023:6726654. doi: 10.1155/2023/6726654. eCollection 2023. PubMed PMID: 36819778; PubMed Central PMCID: PMC9937762. Dai Y, Zhu C, Xiao W, Huang K, Wang X, Shi C, Lin D, Zhang H, Liu X, Peng B, Gao Y, Liu CH, Ge B, Kaufmann SH, Feng CG, Chen X, Cai Y. Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth. J Clin Invest. 2023 Apr 17;133(8). doi: 10.1172/JCI159941. PubMed PMID: 37066876; PubMed Central PMCID: PMC10104892. Xu R, Xiao W, Ding G, Zeng J, Liu H, Cai Y, Chen X. The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity. WIREs Mech Dis. 2023 May-Jun;15(3):e1601. doi: 10.1002/wsbm.1601. Epub 2023 Feb 1. Review. PubMed PMID: 36722620. Ning Y, Wang W, Jordan PM, Barth SA, Hofstetter RK, Xu J, Zhang X, Cai Y, Menge C, Chen X, Werz O. Mycobacterium tuberculosis-Induced Prostaglandin J2 and 15-Deoxy-Prostaglandin J2 Inhibit Inflammatory Signals in Human M1 Macrophages via a Negative Feedback Loop. J Immunol. 2023 May 15;210(10):1564-1575. doi: 10.4049/jimmunol.2200820. PubMed PMID: 37042680. Dai Y, Zhu C, Xiao W, Chen X, Cai Y. Mycobacterium tuberculosis induces host autophagic ferritin degradation for enhanced iron bioavailability and bacterial growth. Autophagy. 2023 May 17;:1-3. doi: 10.1080/15548627.2023.2213983. [Epub ahead of print] PubMed PMID: 37198940.