个人简介

NAME: Zhu, Yanxia POSITION TITLE: Assistant Professor of Stem Cell Biology, Shenzhen University School of Medicine EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE (if applicable)   Completion Date MM/YYYY   FIELD OF STUDY   Jianghan University, Wuhan, China B. Med 07/2004 Clinical Medicine Wuhan University, Wuhan, China M.Sc. 05/2006 Cardiovascular Biology Dalian University of Technology, Dalian, China Ph.D. 01/2010 Biomedical Engineering University of Oxford, Oxford, UK Ph.D. 10/2009 Biomedical Engineering University of Pennsylvania, Philadelphia, USA   Postdoctoral   02/2012   Regenerative Medicine   A.Personal Statement My research fields include stem-cell characteristics and tissue engineering. I have been acknowledged for elucidating the characteristics of induced pluripotent stem cells, adipose-derived stem cells, adipose tissue engineering, skin tissue engineering, cartilage tissue engineering, bone tissue engineering and intervertebral disc tissue engineering. I have published > 20 SCI papers, which together have been cited >800 times. One of my studies that determined the characteristics of adipose-derived stem cells has been cited >500 times to date. B.Positions and Honors Positions and Employment 09/2013 – presentAssistant Professor, Department of Cell Biology and Genetics, Shenzhen University School of Medicine, Shenzhen, China

研究领域

stem-cell characteristics and tissue engineering

Ongoing Research Support Innovation and entrepreneurship project for overseas high-level talents of Shenzhen (KQJSCX20180328095512554) 03/20/2019 to 03/20/2021 Yanxia Zhu, PI ￥800,000 Electro spun membrane with sandwich-like adipose-derived stem cell sheets promote the secretion of exosomes and repair of epidermis Shenzhen Science and Technology Innovation Commission grant (JCYJ20170818100526471)03/01/2018 to 03/30/2020 Yanxia Zhu, PI ￥500,000 Nucleus pulposus-like environment promote the construction of nucleus pulposus tissue by ADSCs Medical Scientific Research Foundation of Guangdong Province (A2018555) 07/01/2018 to 06/30/2020 Yanxia Zhu, PI ￥5,000 Adipose-derived stem cells combined with microenvironment mimic for the construction of nucleus pulposus tissue Completed Research Support NSFC (China) (81301597)01/01/2014 to 12/31/2016 Yanxia Zhu, PI ￥230,000 iPSC as intervertebral disc disease model for the study of DDD mechanism  Shenzhen Science and Technology Innovation Commission grant (JCYJ20160422090807181)07/01/2016 to 12/30/2018 Yanxia Zhu, PI ￥300,000 The development of skin tissue using ADSCs and cell sheet engineering Scientific Research Foundation for Returned Scholars, Finance Commission of Shenzhen Municipality                        05/01/2015 to 12/31/2017 Yanxia Zhu, PI ￥2,700,000 The application of RNA activation and temperature responsive techniques in the construction of engineered intervertebral disc Shenzhen Science and Technology Innovation Commission grant (JCYJ20150525092940984)07/01/2015 to 12/30/2017 Yanxia Zhu, PI ￥100,000 The construction of engineered intervertebral disc Shenzhen Science and Technology Innovation Commission grant (JCYJ20130326110154156)01/01/2013 to 12/30/2014 Yanxia Zhu, PI ￥100,000 The study of DDD mechanism using iPSC as model

近期论文

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1.Liu KX, Zhu YX (co-first author), Yan YM, Zeng Y, Jiao YB, Qin FY, Liu JW, Zhang YY, Cheng YX. Discovery of Populusone, a Skeletal Stimulator of Umbilical Cord Mesenchymal Stem Cells from Populus euphratica Exudates. Org Lett. 2019, 21(6):1837-1840. 2.Jia-Wang Liu, Ming-Yu Zhang, Yong-Ming Yan, Xiao-Yi Wei, Lu Dong, Yan-Xia Zhu* and Yong-Xian Cheng*. Characterization of sesquiterpene dimmers from resina commiphora that promote adipose-derived stem cell proliferation and differentiation. The Journal of Organic Chemistry. 2018, 83, 2725−2733 3.Zhu Y*, Liang Y, Zhu H, Lian C, Gu H, Zou X, Zhou G. Generation and Functional Characterization of Induced Pluripotent Stem Cells (iPSCs) from Human Intervertebral Disc Nucleus Pulposus Cells. Oncotarget, 2017, 8（26）： 42700-42711 4.Zhu Y*, Tan J, Zhu H, Lin G, Yin F, Wang L, Song K, Wang Y, Zhou G. Development of Kartogenin-conjugated chitosan- hyaluronic acid hydrogel for nucleus pulposus regeneration. Biomaterials Science, 2017, 5：784-791。 5.Zhangsong Wu, Zhiqiang Luo, Cuihong Lian, Mingyu Zhang, Guangqian Zhou, Yanxia Zhu*. Generation and Functional Characterization of Induced Pluripotent Stem Cells From Human Intervertebral Disc Nucleus Pulposus Cells. Progress in Biochemistry and Biophysics. 2017，44: 1-10. 6.Yanxia Zhu*, Xiaomin Wu, Yuhong Liang et al. Repair of cartilage defects in osteoarthritis rats with induced pluripotent stem cell derived chondrocytes. BMC Biotechnology, 2016, 16(1): 78-88. 7.Yanxia Zhu, Kedong Song, Siyu Jiang et al. Numerical simulation of mass transfer and three-dimensional fabrication of tissue engineered cartilages based on chitosan/gelatin hybrid hydrogel scaffold in a rotating bioreactor. Appl Biochem Biotechnol. 2016, 179（459）：1-17. 8.Kedong Song, Liying Li, Yanxia Zhu (co-first author) et al. Three-dimensional dynamic fabrication of engineered cartilage based on chitosan/gelatin hybrid hydrogel scaffold in a spinner fask with a special designed steel frame. Materials Science and Engineering. 2015, 55: 384-392. 9.Kedong Song, Wenfeng Li, Yanxia Zhu (co-first author) et al. Dynamic fabrication of tissue engineering bone substitutes based on derived cancelious bone scaffold in a spinner flask bioreactor system. Appl Biochem Biotechnol. 2014, 174(4): 1331-1343. 10.Yanxia Zhu, Zhuxin Dong, Uchechukwu C. Wejinya, et al. Determination of Mechanical Properties of Soft Tissue Scaffolds by Atomic Force Microscopy Nanoindentation. Journal of Biomechanics. 2011, 44(13): 2356-2361. 11.Yanxia Zhu, Tianqing Liu, Xuehu Ma, et al. Enhancement of ADSC Differentiation in Scaffolds with IGF-1 Gene Impregnation under Dynamic Microenvironment. Stem Cells and Development. 2010, 19(10): 1-10. 12.Yanxia Zhu, Tianqing Liu, Kedong Song, et al. Adipose Tissue-derived Stem Cells Differentiated into Cardiomyocytes in Cardiac Microenvironment. Progress in Biochemistry and Biophysics. 2009, 36(4): 1-9. 13.Yanxia Zhu, Tianqing Liu, Kedong Song, et al. ADSCs differentiated into cardiomyocytes in cardiac microenvironment. Mol Cell Biochem, 2009, 324(1-2): 117-129. 14.Yanxia Zhu, Tianqing Liu, Kedong Song, et al. Ex vivo expansion of adipose tissue-derived stem cell in spinner flask. Biotechnology Journal. 2009, 4(8): 1198-1209. 15.Yanxia Zhu, Tianqing Liu, Kedong Song, et al.Collagen-chitosan polymeric scaffolds for the in vitro expansion of human adipose tissue-derived stem cells. J Mater Sci: Mater Med, 2009, 20(3): 799-808. 16.Yanxia Zhu, Tianqing Liu, Kedong Song, et al. Adipose-derived stem cell: a better stem cell than BMSC. Cell Biochemistry and Function, 2008, 26(6): 664-675.