李芳 - 大连医科大学

个人简介

李芳 ,博士，教授，博士生、硕士生导师。现任大连医科大学基础医学院免疫教研室教授。荣获大连医科大学先进工作者、教学名师、良师益友等。

研究领域

1、人趋化因子CXCL8的定点突变、高亲和力的受体拮抗剂（CXCR1/2受体拮抗剂）的构建、表达及体内外活性的研究（国家自然科学基金）。 2、CXCR1/2受体拮抗剂对炎症和自身免疫性疾病（细菌性肺炎、银屑病、关节炎）的治疗作用及其机制的研究（国家自然科学基金）。 3、人CXCR1/2受体拮抗剂的对肿瘤生长、转移和血管形成的抑制作用及其机制的研究（前列腺癌、肝癌和黑色素瘤）。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Cheng HT, Yu HY, Gordon JR, Li F*, Cheng JW*. Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8(3-72)K11R/G31P. Molecules. 2017 Jul 21;22(7). pii: E1229. 通讯作者 2. Cui, Siyuan; Zhu, Yujie; Du, Jianling; Khan, Muhammad Noman; Wang, Bing; Wei, Jing; Cheng, Jya-Wei; Gordon , John R.; Mu, Yutian; Li, Fang.CXCL8 Antagonist Improves Diabetic Nephropathy in Male Mice With Diabetes and Attenuates High Glucose-Induced Mesangial Injury. ENDOCRINOLOGY , 2017, JUN ; 158 ( 6 ): 1671 - 1684. 通讯作者 3.Wang B, Ma Z, Wang M, Sun X, Tang Y, Li M, Zhang Y, Li F*, Li X*. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators Inflamm. 2017; 2017:1567120. doi: 10.1155/2017/1567120. Epub 2017 Jun 4. IF 3.232. 通讯作者 4. Zhichao Ai, Wei Jing, Li Fang.Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation. PLoS One. 2016 Jan 22;11(1):e0147424. 通讯作者 5. Muhammad Noman Khan, Bing Wang, Jing Wei, Yingqiu Zhang, Qiang Li, Xuelin Luan, Jya-wei Cheng, John R. Gordon, Fang Li, Han Liu. CXCR1/2 antagonism with CXCL8/interleukin-8 analogue CXCL8(3-72 ) KIIR/G31P restrict lung cancer growth by inhibiting tumor cell proliferation angiogenesis. Oncotarget. 2015 Aug 28;6(25):21315-27. 通讯作者 6. Lingyun Li, Muhammad Noman Khan, Qiang Li, Xiangyu Chen, Jing Wei,Bing Wang, Jya -wei Cheng, John R. Gordon and Fang Li .G31P, CXCR1/2 inhibitor, with cisplatin inhibits the growth of mice hepatocellular carcinoma and mitigates high‑dose cisplatin-induced nephrotoxicity 2015 Oncology reports 33: 751-757. 通讯作者 7. Jing Wei,, Xiangyu Chen, Qiang Li, Jifei Chen, Noman Khan, Bing Wang, Jya-Wei Cheng, John R. Gordon and Fang. Li. ELR-CXC chemokine antagonism and cisplatin co-treatment additively reduce H22 hepatoma tumor progression , andameliorate cisplatin-induced nephrotoxicity 2014 Oncology reports 31: 1599-1604通讯作者 8. YuanHua Qin，FuShun Fan，Ying Zhao，Ying Cui，XiaoQing Wei，Kazuhiro Kohama，John R. Gordon，Fang Li，Ying Gao. Recombinant Human CXCL8(3-72)K11R/G31P Regulates Smooth Muscle Cell Proliferation and Migration Through Blockage of Interleukin-8 Receptor. 2013 Research Communication 65（1） 67~75通讯作者 9. Jing Wei, Jing Peng, Bing Wang, Hong Qu, ShiyiWang, Aziz Faisal,Jia-Wei Cheng, John R. Gordon, and Fang Li. CXCR1/CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection. 2013.BioMed Research International Volume, 1-6通讯作者 10. Xin Lliu, Jing Peng, Wenchang Sun, Shufen Yang, Guoying Deng, Fang Li, Jya-wei Chen and John R. Gordon. G31P, an antagonist against CXC chemokine receptors 1 and 2, inhibits growth of human prostate cancer cells in nude mice. Tohoku J Exp. Med 2012, 228, 147~156 通讯作者