侯洁 - 大连医科大学

个人简介

侯洁, 博士，副教授，硕士生导师（生物技术专业）。现任大连医科大学基础医学院生物技术系教师，大连医科大学七年制第一阶段导师，八年制创新培养导师。近年来围绕肿瘤相关靶蛋白，开展了多种关键蛋白的生物示踪及功能研究，在肿瘤相关靶点的生物示踪及抗肿瘤药物作用机制研究方面开展了一系列创新性工作，相关工作先后发表在Chem Commun、Biosensors & Bioelectronics、Biomacromolecules、Sensors and Actuators B: Chemical、Journal of Biomedical Material Research, Part A、Biomacromolecles等化学生物学及生物医药研究领域的著名国际学术刊物上。目前已主持完成国家自然科学基金（青年基金）1项、国家重点实验开放课题1项，并已主持完成辽宁省自然基金1项（编号: 2013023049）、辽宁省教育厅基金1项（编号: L2013345）。作为主要参与人，先后参与了国家863计划、973计划“糖蛋白在肿瘤免疫识别中的作用”（2007CB914803)、天津市应用基础及前沿技术研究计划项目等多个科研项目。在相关研究领域发表论文50余篇，其中SCI收录42篇；担任《Journal of Biomedical Material Research: Part A》及《Journal of Chromatography B》等国际刊物审稿人，参与编写专著两部（《中药药物代谢动力学研究思路与实践》，刘昌孝主编）及（《系统药代动力学》，杨凌主编），申请国家发明专利14件，已授权3件。获辽宁省自然科学学术论文成果奖三等奖两项，入选辽宁省百千万人才计划，大连市科技之星项目及大连医科大学英才计划-后备人才计划。

研究领域

肿瘤靶向治疗

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Weng ZM, Ge GB, Dou TY, Wang P, Liu PK, Tian XH, Qiao N, Yu Y, Zou LW, Zhou Q, Zhang WD, Hou J*(侯洁). Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2. Bioorg Chem. (IF = 3.231) 2018; 77: 320-329. 2. Weng ZM, Wang P, Ge GB, Dai ZR, Wu DC, Zou LW, Dou TY, Zhang TY, Yang L, Hou J*(侯洁). Structure-activity relationships of flavonoids as natural inhibitors against E. coli β-glucuronidase. Food Chem Toxicol. (IF = 3.778) 2017; 109:975-983. 3. Feng L1, Liu ZM1, Hou J1, Lv X, Ning J, Ge GB, Cui JN, Yang L. A highly selective fluorescent ESIPT probe for the detection of human carboxylesterase 2 and its biological applications. Biosensors & Bioelectronics (IF = 7.476), 2015.03, 65: 9-15. 2. Ning J1, Hou J1, Wang P, Wu JJ, Dai ZR, Zou,LW, Li W, Ge GB, Ma XC, Yang L. Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human. Xenobiotica (IF = 1.723)，2015，45(11)：954-960。 (3) Li YG1, Hou J1, Li SY, Lv X, Ning J, Wang P, Liu ZM, Ge GB, Ren JY, Yang L(*)，Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase2，Fitoterapia (IF = 2.345), 2015, 101: 99-106. (4) Liu ZM1, Feng L1, Hou J1, Lv X, Ning J, Ge GB, Wang KW, Cui JN, Yang L. A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells, Sensors and Actuators B: Chemical (IF = 4.097), 2014, 205: 151-157. (5) Yang XB1, Hou J1, Liu D, Deng S, Wang ZB, Kuang HX, Wang CY, Yao JH, Liu KX, Ma XC. Biotransformation of isoimperatorin by Cunninghamella blakesleana AS 3.970，Journal of Molecular Catalysis B: Enzymatic (IF = 2.823), 2013, 88: 1-6. (6) Lv X, Wang DD, Feng L, Wang P, Zou LW, Hao DC, Hou J*, Cui JN, Ge GB, Yang L. A highly selective marker reaction for measuring the activity of human carboxylesterase1 in complex biological samples, RSC advances (IF = 3.289), 2015, 6: 4302-4309. (7) Hou J*, Shi Q, Cao MR, Pan PW, Ge GB, Fan XR, Bai G, Xin Y. A novel approach for fluorescent visualization of glycyrrhetic acid on a cell with a quantum dot. Biochemistry (Mosc) (IF = 1.303), 2014, 79(1): 25-30. (8) Wang DD, Zou LW, Jin Q, Hou J*, Ge GB*, Yang L, Recent progress in the discovery of natural inhibitors against human carboxylesterases, Fitoterapia, (IF=2.345) 2017, 117: 84-95. (9) 杨刚, 朱亮亮, 吕侠, 吴大畅, 夏杨柳, 马骁驰, 辛毅, 侯洁*, 双酚A葡萄糖醛酸苷的高效制备，高等学校化学学报, (IF = 0.929) 2014, 35(2): 314-318.