高颖 - 大连医科大学

个人简介

高颖博士，教授，博士生导师。现任职于大连医科大学生物化学与分子生物学教研室。兼任辽宁省医学细胞分子生物学重点实验室主任。1984年业于大连医科大学临床医疗专业，获医学学士学位。1993年获生物化学与分子生物学硕士学位。1999年获生物化学与分子生物学专业博士学位。2000年3月至2003年在日本群马大学医学部药理学教研室进行博士后研究工作。先后主持国家自然科学基金项目3项，辽宁省教育厅、科技厅项目2项，教育部科研项目1项。获辽宁省科技进步奖5项，大连市科技进步奖一项。发表学术论文50余篇。学术兼职为辽宁省生物化学与分子生物学专业委员会理事；中华医学会辽宁省遗传学会委员、大连市医学会生化分会委员；中华医学科技奖第二届评审委员会委员；科技部国际科技合作评审专家。

研究领域

血管性疾病相关分子机制研究

近期论文

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(1) Guangxin Lv, Hongmei Zhu, Cai Li, Jingyu Wang, Dandan Zhao, Shuyao Li, Le Ma, Guohua Sun, Fang Li, Ying Zhao*, Ying Gao*. Inhibition of IL-8-mediated endothelial adhesion, VSMCs proliferation and migration by siRNA-TMEM98 suggests TMEM98’s emerging role in Atherosclerosis. Oncotarget. 2017, 8 (50): 88043-88058. (2) Ying Zhao, ChenXu Zhang, XuGe Wei, Pei Li, Ying Cui, YuanHua Qin, MinLi Jin, XiaoQing Wei, Kazuhiro Kohama , Ying Gao*. Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation. Scientific Reports. Srep15352, 2015. (3) Ying Cui, YinWei Sun, HaiShuang Lin, WeiMin Su, Yan Fang, Ying Zhao, XiaoQing Wei, YuanHua Qin, Kazuhiro Kohama, Ying Gao*. Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways. Mol Cell Biochem, 393(1-2):255-263, 2014. (4) Ying Zhao, Miao Lv, HaiShuang Lin, Yan Hong, Ying Cui, XiaoQing Wei, YuanHua Qin, Kazuhiro Kohama, Ying Gao*. Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA. Biochem Biophys Res Commun. 432:488-493, 2013. (5) YuanHua Qin, FuShun Fan, Ying Zhao, Ying Cui, XiaoQing Wei, Kazuhiro Kohama, John Gordon, Fang Li* and Ying Gao*. Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of IL-8 receptor. IUBMB Life. 65(1):67-75, 2013. (6) Ying Zhao, Miao Lv, HaiShuang Lin, Yan Hong, FuChun Yang, YunLiang Sun, Yan Guo, Ying Cui, Sheng Li, Ying Gao*. ROCK1 Induces ERK Nuclear Translocation in PDGF-BB Stimulated Migration of Rat Vascular Smooth Muscle Cells. IUBMB Life. 64(2):194-202, 2012. (7) Shuqing Liu, Fan Yang, Qiaoqiao Zhang, Ming-zhong Sun, Ying Gao*, Shujuan Shao*. “Anatomiacal” view of the protein composition and protein characteristics for Gloydius shedaoensis snake venom via proteomics approach. Anat Rec. 294(2), 273-282, 2011.