个人简介
马郁芳,博士，教授，硕士生及博士生导师。现任大连医科大学基础医学院生物化学教研室。辽宁省新世纪百千万人才工程百层次人选，辽宁省优秀教师。
主要从事结核分枝杆菌细胞壁多糖生物合成代谢规律的研究以及抗结核新药筛选平台的建立，主要工作包括 1) 用基因敲除技术确定分枝杆菌细胞壁合成代谢途径中的各种关键酶作为研发抗结核新药的靶酶,用基因敲减技术研究靶基因对细胞壁结构以及细菌形态和结构的影响；2) 建立高表达靶酶的工程菌，表征靶酶并建立靶酶抑制剂的高通量筛选平台；3)筛选靶酶抑制剂并利用分子对接和基因定点突变技术研究抑制剂的的作用机制；4) 研究甘露糖基化蛋白在分枝杆菌感染宿主巨噬细胞时的识别及毒力作用；5)用宏基因组学和培养组学研究肺部微生物组与肺炎等的关联。
近期论文
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1. Qiulong Yan, Yifang Gu, Xiangchun Li, Wei Yang, Liqiu Jia, Changming Chen, Xiuyan Han, Peng Li, Zhiwei Fang, Junpeng Zhou, Xiuru Guan, Yanchun Ding, Shaopeng Wang, Yi Xin, Muhammad Khan, Shenghui Li, Yufang Ma. Alterations of the gut microbiome in hypertension. Frontiers in Cellular and Infection Microbiology(4.3) 2017, Volume 7, Article 381. doi: 10.3389/fcimb.2017.00381
2. Shanshan Sha, Xiaoxia Shi, Guoying Deng, Lida Chen, Yi Xin and Yufang Ma. Mycobacterium tuberculosis Rv1987 induces Th2 immune responses and enhances Mycobacterium smegmatis survival survival in mice. Microbiological Research (3.037) 2017, 197: 74-80.
3. Guoying Deng, Fei Zhang, Shufeng Yang, Jian Kang, Shanshan Sha, Yufang Ma. Mycobacterium tuberculosis Rv0431, a mannosylated protein, enhanced the mycobacterial survival and modulated cytokines production of RAW 264.7 macrophages. Microbial Pathogenesis (2.009) 2016, 100: 285-292.
4. Liming Xu, Lei Qian, Jian Kang, Shanshan Sha, Xin Yi, Shen Lu, Yufang Ma. Down-regulation of N-acetylglucosamine-1-phosphatetransferase(WecA) enhanced the sensitivity of Mycobacterium smegmatisagainstrifampin. Journal of Applied Microbiology (2.099) 2016, 121: 966-972.
5. Qiulong Yan, Song Cui, Changming Chen, Shenghui Li, Shanshan Sha, Xianyao Wan, Yi Xin, Yufang Ma.Metagenomic analysis of sputum microbiome as a tool towards culture-independent pathogen detection of patients with ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine (13.204)2016, 195(5): 636-639.
6. Xiaofeng Yao,Shanshan Sha, Yuexia Wang, Xiance Sun, Jun Cao, Jian Kang, Liping Jiang, Min Chen, Yufang Ma. Perfluorooctane sulfonate induces autophagy dependent apoptosis through Spinster 1-mediated lysosomal-mitochondrial axis and impaired mitophagy. Toxicological Sciences(4.081)2016, 153(1): 198-211.
7. Xiaofeng Yao and Yufang Ma. Chapter 9. Organic pollutant perfluorooctane sulfonate-induced lysosomal membrane permeabilization blocks autophagy flux in human hepatoma cells. In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Volume 9. Human Diseases and Autophagosome (1st edition) (Edited by Hayat MA).Academic Press(2016), ISBN 978-0128029367. pp176-184.
8. Shanshan Sha, Xiaoxia Shi, Liming Xu, Jiabin Wen, Yi Xin and Yufang Ma.Viability, morphology and proteome of M. smegmatis MSMEG_0319 knockout strain. Proteomics(4.041) 2016, 16: 1090-1099.
9. Xiaoxia Shi,Shanshan Sha, Likun Liu, Xin Li, Yufang Ma. A microtiter plate assay for high-throughput screening of Mycobacterium tuberculosisdTDP-D-glucose-4,6-dehydratase inhibitors. Analytical Biochemistry (2.334) 2016, 498: 53-58.
10. JianjunLiu, Qiulong Yan, Fuwen Luo, Dong Shang, Dachang Wu, Haiquan Zhang, Xueqi Shang, Xiaoli Kang, Meyiah Abdo, Beibei Liu, YufangMa and Yi Xin. Acute cholecystitis associated with infection ofEnterobacteriaceaefrom gut microbiota. Clinical Microbiology and Infection (4.575)2015, 21(9):851.e1-9.
11. Shufeng Yang, Fei Zhang, Jian Kang, Wenli Zhang, Guoying Deng, Yi Xin, Yufang Ma. Mycobacterium tuberculosis Rv1096 protein: gene cloning, protein expression,and peptidoglycan deacetylase activity. BMC Microbiology (2.729) 2014, 14:174.
12. Xiao-Feng Yao, Jun Cao, Li-Ming Xu, Xian-Ce Sun, Jian Kang, Guang Yang, Li-Ping Jiang, Cheng-Yan Geng, Chuan-Zhou Gao, Lai-Fu Zhong, Yu-Fang Ma. Perfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells. Food and Chemical Toxicology (2.895) 2014, 67:96-104.
13. Liming Xu, Dongting Wu, Liang Liu, Qi Zheng, Yu Song, Li Ye, Shanshan Sha, Jian Kang, Yi Xin, Yufang Ma. Characterization of mycobacterial UDP-N-acetylglucosamine enolpyruvyle transferase (MurA). Research in Microbiology(2.705)2014, 165:91-101.
14. Huajun Li, Jya-Wei Cheng,Hui-Yuan Yu, Yi Xin, Li Tang and Yufang Ma. Effect of the antimicrobial peptide D-Nal-Pac-525 on the growth of Streptococcus mutans and its biofilm formation. Journal of Microbiology and Biotechnology (1.32),2013, 23(8):1070-1075.
15. Jian Kang, Liming Xu, Shufeng Yang, Wendan Yu, Shuo Liu, Yi Xin and Yufang Ma. Effect of phosphoglucosamine mutase on biofilm formation and antimicrobial susceptibilities in M. smegmatis glmM gene knockdown strain. PLoS One (3.534), 2013, 8(4): e61589.
16. Sebabrata Mahapatra, Charles Piechota, Filipa Gil, Yufang Ma, Hairong Huang, MichaelS. Schermana, Victoria Jones, Martin S. Pavelka, Jr., Jose Moniz-Pereira, Madalena Pimentel,Michael R. McNeiland Dean C. Crick.Mycobacteriophage Ms6 LysA is a peptidoglycan amidase and a useful analytical tool.Applied and Environmental Microbiology (3.952) 2013, 79:768-773.
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