个人简介
李文哲
职务: 教授
专业: 生物化学与分子生物学
Education/Working Experience
2013- Present Prof. College of Basic Medical Sciences, Dalian medical University.
2007- 2012Prof. College of Bioengineering, Dalian University, China
2003 - 2007Postdoctoral fellowship, Department of Glycotherapeutics, Graduate School of Medicine, OsakaUniversity, Japan. Field:Glycobiology
1999 - 2003Ph.D.Student, in Laboratory of Immunology, Osaka Prefecture University, Japan. Field: Mucosal Immunization.
1997- 1999 Student, in Laboratory of Immunology, Osaka Prefecture University, Japan.
1996 - 1997 Research Associate. Department of Immunology & Microbiology, Yanbian University, China.
1993 - 1996Master course Student, inLaboratory of Immunology,Department of Veterinary Science, Yanbian University, China.
1989 - 1993Bachelor course student, in Department of Veterinary Science, Yanbian University, China. Field: Veterinary Medicine
Research Projects/Grants
1. Regualtion of core fucosyltransferase on the CD4+ T cell activation and proliferation. National Natural Science Foundation of China (NSFC)-31570797,2016.1-2019.12, 780,000RMB.
2. The mechanism of core fucosylation in mature B cell recognition of Ag, activation and Ab production. National Natural Science Foundation of China (NSFC)-31270864,2013.1-2016.12, 800,000RMB.
3.Roles of Fut8 in pre-B cell proliferation and differentiation. National Natural Science Foundation of China (NSFC)-30972675.2010.1-2012.12, 320,000RMB.
AdmissionPlan/Requirements
One graduated student / year
The student should have a good English writing ability and some research experience.
近期论文
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1. Xue K, Song J, Yang Y, Li Z, Wu C, Jin J,W. Li*.PAX5 promotes pre-B cell proliferation by regulating the expression of pre-B cell receptor and its downstream signaling. Mol Immunol.2016 Mar 23;73:1-9.
2. W. Li *, R. Yu, B. Ma, Y. Yang, X. Jiao, Y. Liu,H. Cao, W. Dong, L. Liu, K. Ma,T. Fukuda, Q. Liu, T. Ma, Z. Wang,J. Gu, J. Zhang and N. Taniguchi.Core fucosylation of IgG-BCR is required forantigen recognition andantibody production.Journal of Immunology. 2015,Mar 15;194(6):2596-606.
3. W. Li, D. Wang, Y. Chi, R. Wang, F. Zhang, G. Ma, Z. Chen, J. Li, Z. Liu,E. Matsuura and Q. Liu. 7-ketocholesteryl-9-carboxynonanoate enhances the expression ofATP binding cassette transporter A1 via CD36. Atherosclerosis, 2013, 226(1), 102-109.
4. Y. Pang, Y. Zhang, H. Wang, J. Jin, J. Piao, J. Piao, Q. Liu,W. Li *.Reduction ofSalmonella enteritidisnumber after infections by immunization of liposomes-associated recombinant SefA.Avian Disease2013;57(3):627-33.
5. W. Li *, Q. Liu, Y. Pang, J. Jin, H. Wang, H. Cao, Z. Li, X. Wang, B. Ma, Y. Chi, R. Wang, A. Kondo, J. Gu, andN. Taniguchi.Core fucosylation ofmu heavy chains regulates the assembly ofprecursorB cell receptors and itsintracellular signaling. Journal of Biological Chemistry 2012, 287(4): 2500-2508.
6. Y. Zhang*,W. Li * et al. Recombinant domain V of β2-glycoprotein I inhibits the formation of a 7-ketocholesteryl-9-carboxynonanoate and β2-glycoprotein I complex.Journal of Biochemisty 2011 Jan;149(1):35-42.
7. Y. Pang, H. Wang,Z. Li, J. Piao, J. Piao, Y. Chi, J. Jin, Q. Liu,W. Li *. Immune response to liposomes associated recombinant SEF21 following oral immunization in chickens.Avian Disease2012 Jun; 56(2): 347-353.
8. Z. Huang *,W. Li * et al. 7-ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages.Life Science 2010, 87(19-22): 651-657.
9. W. Li et al. Reduced {alpha}4{beta}1 integrin /VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice.Glycobiology. 2008, 18(1): 114-124.
10.W. Li et al. Down regulation of trypsinogen expression is associated with growth retardation in alpha 1,6-fucosyltransferase-deficient mice: attenuation of proteinase-activated receptor 2 activity.Glycobiology. 2006, 16(10): 1007-1019.
学术兼职
2012-2016 Member of the Chinese Society for Immunology
2006-2016 Member of theJapanese Society for Immunology
2006-2016 Member of theJapanese Society forGlycobiology
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