柳林华 - 大连医科大学

个人简介

柳林华,博士，副教授，硕士生导师。从事研究工作以来一直致力于分子细胞生物学相关的研究工作。曾先后主持完成中国博士后基金一项，国家自然科学基金青年科学基金1项。至今共发表论文9篇，全部为SCI收录杂志。

研究领域

1. Wnt信号通路在肿瘤的发生发展中的作用机制研究。 2. Wnt信号通路与细胞周期间的交互（cross-talk）过程。 3. DNA复制起始因子Cdc6在细胞周期和细胞凋亡过程中作用机制研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Liu L*, Yim H, Choi JH, Kim ST, Jin Y, Lee SK*. ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α-induced apoptosis of HeLa cells. FEBS Lett. 2014, 3, 588(6):929-35. IF: 3.58. 2. Hua Chen1, Linhua Liu1, Benyu Ma1, Ting Martin Ma, Jun-Jie Hou, Guo-Ming Xie, Wei Wu, Fu-Quan Yang, and Ye-Guang Chen*, Protein Kinase A-mediated 14-3-3 association impedes human Dapper1 to promote Dishevelled degradation. The Journal of Biological Chemistry, 2011, 4, 286(17):14870-80, IF：4.78. 3. Linhua Liu, Jae Hyuk Choi, Hyungshin Yim, Joon Seok Choi, Byoung Duck Park,Seung Ju Cho, Seung Ki Lee*, ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells. The International Journal of Biochemistry & Cell Biology, 2009, 6, 41(6):1410-20. IF: 4.8. 4. Li W, Yu R, Ma B, Yang Y, Jiao X, Liu Y, Cao H, Dong W, Liu L, Ma K, Fukuda T, Liu Q, Ma T, Wang Z, Gu J, Zhang J, Taniguchi N. Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production. J Immunol. 2015, 194(6):2596-606. IF:5.52 5. Annani-Akollor ME, Wang S, Fan J, Liu L, Padhiar AA, Zhang J. Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling. Biomed Pharmacother. 2014, 68(6):785-90. IF:2.07 6. Yu, S., Fan, J., Liu, L., Zhang, L., Wang, S.*, and Zhang, J.* Caveolin-1 up-regulates integrin alpha2,6-sialylation to promote integrin alpha5beta1-dependent hepatocarcinoma cell adhesion. FEBS Lett. 2013, 587: 782-787. IF: 3.58 7. Yim H, Park JW, Woo SU, Kim ST, Liu L, Lee CH, Lee SK. Phosphorylation of Cdc6 at serine 74, but not at serine 106, drives translocation of Cdc6 to the cytoplasm. J Cell Physiol. 2013 Jun; 228(6):1221-8. IF:4.22 8. Nanyang Li, Lijun Zhang, Linhua Liu, Shujing Wang, Jianhui Fan, Jianing Zhang, Wnt/β-catenin up-regulates hFUT8 expression in hepatocarcinoma cell SMMC-7721. Glycoconjugate J. 2013, 30 (4) :438. IF: 1.88 9. Yu, S., Zhang, L., Li, N., Fan, J., Liu, L., Zhang, J.*, and Wang, S.* Caveolin-1 up-regulates ST6Gal-I to promote the adhesive capability of mouse hepatocarcinoma cells to fibronectin via FAK-mediated adhesion signaling. Biochem. Biophys. Res. Commun. 2012, 427: 506-512. IF:2.4