石磊 - 大连医科大学

个人简介

石磊，博士，研究员，硕士生导师。现任大连医科大学基础医学院, “长江学者实验室”教师。2014年入选“辽宁省百千万人才工程万层次人才”；2015年入选大连市“科技之星”计划；担任国家自然基金委初审专家。 2014年至今，主持国自然面上项目一项，主持国自然青年项目一项，教育部留学回国人员启动项目一项，辽宁省博士启动项目一项，中科院药物研究所国家重点实验室开放课题一项。以第一作者和参与作者发表SCI论文12篇，其中通讯或第一作者论文9篇, 包括在心血管领域具有较高影响力的专业杂志，Circulation Research, Hypertension， Cardiovascular research等。

研究领域

1）miR-223维持内皮稳态对动脉粥样硬化形成的影响及机制研究 2）新型骨架蛋白对血管新生及血管稳态调节及机制研究 3）肝脏代谢疾病

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、Ruan W, Zhao F, Zhao S, Zhang L, Shi L*, Pang T* Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells. Gene 2018 Apr 05 ;649（通讯作者，IF 2.41） 2、Zhang N, Liu L, Fan N, Zhang Q, Wang W, Zheng M, Ma L, Li Y, Shi L, The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11402. (Lei Shi, 通讯作者IF 5.008) 3、 Lei Shi, Baktybek Kojonazarov, Amro Elgheznawy, Rüdiger Popp, Bhola Kumar Dahal, Mario Böhm, Soni Savai Pullamsetti, Hossein-Ardeschir Ghofrani, Axel Gödecke, Andreas Jungmann, Hugo A. Katus, Oliver J. Müller, Ralph T. Schermuly, Beate Fisslthaler, Werner Seeger, Ingrid Fleming, miR-223–IGF-IR signaling in hypoxia- and load-induced right ventricular failure: a novel 2 therapeutic approach，Cardiovasc Res. 2016 Aug 1;111(3):184-93. doi: 10.1093/cvr/cvw065 (IF:5.94) 4、Ning Tang+, Lei Shi+, Zhenlong Yu+, Peipei Dong, Chao Wang, Xiaokui Huo, Baojing Zhang, Shanshan Huang, Sa Deng, Kexin Liu, Tonghui Ma , Xiaobo Wang, Lijun Wu, Xiaochi Ma. Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway, Oncotarget. 2016 Jan 19;7(3):3533-47. doi: 10.18632/oncotarget.6514 (IF 5.008, +并列一作) 5、Elgheznawy A, Shi Lei, Randriamboavonjy V and Fleming I. Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes, Circ Res; 2015.05.05 ( IF 11.86) 6、 Khader Awwad, Jiong Hu, Lei Shi, Nicole Lill, Randa Abdel Malik, Nina Zippel, Beate Fisslthaler, Johannes A. Eble, Josef Pfeilschifter, Rüdiger Popp, Ingrid Fleming. Role of secreted modular calcium binding protein 1 (SMOC1) in transforming growth factor β signaling and angiogenesis, Cardiovascular research. 2015 May 1;106(2):284-94. doi: 10.1093/cvr/cvv098. Epub 2015 Mar 5. (IF:5.808) 7、 Shi L, Fisslthaler B, Zippel N, Frömel T, Hu J, Elgheznawy A, Heide H, Popp R, Fleming I. MicroRNA-223 Antagonizes Angiogenesis by Targeting β1 Integrin and Preventing Growth Factor Signaling in Endothelial Cells. Circ Res; 113(12):1320-30. 2013 Dec 6 （IF: 11.861） 8、 Kohlstedt K, Trouvain C, Boettger T, Shi L, Fisslthaler B, Fleming I. AMP-activated protein kinase regulates endothelial cell angiotensin-converting enzyme expression via p53 and the post-transcriptional regulation of microRNA-143/145. Circ Res; 112(8):1150-8. 2013 Apr 12 （IF: 11.861） 9、 Shi L, Fleming I. One miR level of control: microRNA-155 directly regulates endothelial nitric oxide synthase mRNA and protein levels. Hypertension; 60(6):1381-2. 2012 Dec （IF: 6.873）