秘晓林 - 大连医科大学

个人简介

秘晓林，博士，教授，博士生导师。大连医科大学基础医学院副院长，生物科学系主任。入选中国科学院“引进国外杰出人才--百人计划”，辽宁省“攀登学者”。国家科技奖会评专家，国家重大科学研究计划、国家自然科学基金、博士后科学基金、美国国家科学基金研究生项目等评议人，SCI杂志International Journal of Nanomedicine顾问编委，Journal of Biochemistry and Molecular Biology Research编委，中国生化药物杂志编委，中国环境诱变剂学会理事，Biomaterials、Genetics、International Journal of Nanomedicine、PLoS One等杂志审稿人。主持国家重点基础研究计划“973”课题、国家自然科学基金面上项目、中国科学院创新项目等。 1990年毕业于兰州大学，获生物化学学士学位。1996年毕业于卫生部兰州生物制品研究所，获免疫学和微生物学硕士学位。1999年毕业于中国预防医学科学院病毒学研究所，获病原生物学博士学位。同年赴美国，在国立卫生研究院（National Institutes of Health）癌症研究所（National Cancer Institute）从事博士后研究，随后任职美国国立卫生研究院癌症研究所研究员。作为通讯作者，研究成果发表在Proceedings of National Academy of Sciences USA, Oncogene, Human Molecular Genetics, Biomaterials, Journal of Cell Science, Nanotoxicology等国际知名学术期刊。

研究领域

1. 非编码RNA（miRNA和lncRNA）应答DNA损伤，调节染色质重构、细胞周期、凋亡的功能和机制； 2. 肠道干细胞再生与分化的表观遗传调控。

近期论文

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1. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. * miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. 114(12): E2365-E2374. IF 9.7 2. Cong W., Wang P., Qu Y., Tang J., Bai R., Zhao Y., Chen C. , Bi X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6 3. Chen H., Wang B., Feng W., Du W., Ouyang H., Chai Z., Bi X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9 4. Fang G., Zhang D., Yin H., Zheng L., Bi X.*, Yuan L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127:1631-1639. IF 5.4 5. Wang Y., Wang Z., Joshi BH., Puri R., Stultz B., Yuan Q., Bai Y., Zhou P., Yuan Z., Hursh DA., Bi X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-3866. IF 8.6 6. Liu W., Jiang F., Bi X.*, Zhang Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-4668. IF 7.7 7. Kong L., Yuan Y., Zhu H., Li Y., Guo Q., Zhao Y., Wang Q., Bi X.*, Gao X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6 8. Gao G., Bi X., Chen J., Srikanta D., Rong YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proc. Nat. Acad. Sci. USA. 2009. 106(26): 10728–10733.(Equal contribution). IF 9.4 9. Bi X., Jones T., Abbasi F., Lee H., Stultz B., Hursh D., Mortin M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8 10. Bi X., Srikanta D., Fanti L., Pimpinelli S., Badugu R., Kellum R., Rong Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc. Nat. Acad. Sci. USA. 2005. 102(42):15167-15172. IF 10.2 11. Bi X., Wei S.D., Rong Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9 12. Bi X., Kajava A., Demidenko Z., Jones T., Mortin M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9