个人简介
赵杰，男，教授，博士研究生导师。大连医科大学副校长，神经退行性疾病药物研发国家地方联合工程中心主任、辽宁省防治老年神经退行性病天然产物工程技术研究中心主任、辽宁省抗老年神经退行性疾病天然产物工程实验室主任。国务院特殊津贴获得者，辽宁省特聘教授，大连市优秀专家。长期从事癫痫、神经退行性疾病的发病机制和防治策略研究，多次获国家自然科学基金资助并获得国家科技部新药创制重大专项课题。研究成果获中华医学科技三等奖1项，辽宁省政府科技进步二等奖6项、三等奖2项，国内外发表论文百余篇。
近期论文
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1.Chen JJ, Zhao B, Zhao J*, Li S*. Potential roles of exosomal microRNAs as diagnostic biomarkers and therapeutic application in Alzheimer’s disease. Neural Plasticity. 2017; 2017:7027380. doi: 10.1155/2017/7027380. Epub 2017 Jul 9.
2.Lan YL#, Zhao J#, Ma TH*, Li S*. The potential roles of aquaporin 4 in Alzheimer's disease. Mol Neurobiol. 2016 Oct; 53(8): 5300-9. doi: 10.1007/ s12035-015-9446-1.
3.Zhang XG#, Wang X #, Zhou TT, Wu XF, PengY, Zhang WQ, Zhao J*, Li S*, Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans from β-Amyloid Toxicity. Front Pharmacol. 2016 Jul 26; 7: 227. doi: 10.3389/ fphar.2016.00227. eCollection 2016.
4.Chen JJ, Wang T, An CD, Jiang CY, Zhao J*, Li S*. Brain-derived neurotrophic factor: a mediator of inflammation-associated. Rev Neurosci. 2016 Dec 1;27(8):793-811. doi: 10.1515/revneuro-2016-0017.
5.Lan YL#, Zou S#, Chen JJ, Zhao J*, Li S*. The neuroprotective effect of the association of aquaporin-4/glutamate transporter 1 (AQP4/GLT-1) against Alzheimer’s disease. Neural Plasticity. 2016, Article ID 4626593, 8 pages http://dx.doi.org/ 10.1155 /2016/ 4626593.
6.Lan YL#, Zhao J#, Ma TH*, Li S*. The research update on the potential roles of aquaporin 4 in neuroinflammation. Acta Neurol Belg, 2016 Jun;116(2): 127-34
7.Zhou TT#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease. Int Immunopharmacol. 2015 Nov 5. pii: S1567-5769(15) 30165 -X. doi: 10.1016/j.intimp.2015.10.032.
8.Zhou T#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease. Neuropharmacology. 2015 Oct 23; 101: 480-489. doi: 10.1016/j.neuropharm. 2015.10.024.
9.Lan YL#, Zhao J#, Ma TH*, Li S*. The great significance of research into the physiological relevance between AQP4 and vasopressin for studying Alzheimer's disease. J Alzheimers Dis Parkinsonism 5: 192. doi:10.4172/2161- 0460.1000192
10.Cao Z, Wu XF, Peng Y, Zhang R, Li N, Yang JY, Zhang SQ, Zhang WQ, Zhao J*,Li S*. Scorpion Venom Heat-Resistant Peptide Attenuates Glial Fibrillary Acidic Protein Expression via c-Jun/AP-1. Cell Mol Neurobiol. 2015 Nov; 35(8): 1073-9. doi: 10.1007/s10571-015-0215-5. Epub 2015 Jul 2.
11.Yang JY*, Yang G, Ren J, Zhao J*, Li S*. Caffeine suppresses GABA receptor-mediated current of rat primary sensory neurons via inhibiting intracellular phosphodiesterase. Neurophysiology，April 2015, Volume 47, Issue 2, pp 108-114
12.Lan YL, Zhao J*, Li S*. Update on the Neuroprotective Effect of Estrogen Receptor Alpha against Alzheimer ’s disease. J Alzheimer’s Dis. 2015; 43(4): 1137-48.
13.Lan YL, Zhao J*, Li S. Update on the neuroprotective effect of estrogen receptor alpha against Alzheimer's disease. J Alzheimers Dis. 2015; 43 (4): 1137-48.
14.Wang T, Wang SW, Zhang Y, Wu XF, Peng Y, Cao Z, Ge BY, Wang X, Wu Q, Lin JT, Zhang WQ, Li S, Zhao J*. Scorpion venom heat-resistant peptide (SVHRP) enhances neurogenesis and neurite outgrowth of immature neurons in adult mice by up-regulating brain-derived neurotrophic factor (BDNF). PLoS One. 2014; 9(10): e109977.
15.Wang T, Xia YL, Zhang SL, Gao LJ, Xie ZZ, Yang YZ, Zhao J*. The impact of hypertension on the electromechanical properties and outcome of catheter ablation in atrial fibrillation patients. J Thorac Dis. 2014; 6(7): 913-20.
16.Yin SM, Zhao D, Yu DQ, Li SL, An D, Peng Y, Xu H, Sun YP, Wang DM, Zhao J*, Zhang WQ. Neuroprotection by scorpion venom heat resistant peptide in 6-hydroxydopamine rat model of early-stage Parkinson's disease. Sheng Li Xue Bao. 2014;66(6):658-66.
17.Lan YL, Zhao J*, Li S. Estrogen receptors' neuroprotective effect against glutamate-induced neurotoxicity. Neurol Sci. 2014;35(11):1657-62.
18.Li li Guan, Haiyan Feng, Dezheng Gong, Xu Zhao, Li Cai, Qiong Wu, Bo Yuan, Mei Yang, Jie Zhao*, Yuan Zou. Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. Experimental Gerontology. 2013; 48(12): 1387-94.
19.Wang ZC, Zhao J*, Li S. Dysregulation of Synaptic and Extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β. Neurosci Bull. 2013; 29(6): 752-760.
20.Y. Sun, X. Cui, Sh. Yin, D. Yu, Sh. Li, W. Zhang, and J. Zhao*. Effects of Scorpion Venom Heat-Resistant Protein on Seizure Behavior and Expression of Proenkephalin in Rats with Kainate-Induced Epilepsy. Neurophysiology. 2013; 45(4): 319-322.
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