个人简介

Ph.D., Massachusetts Institue of Technology (1973); B.S., The University of Rochester (1969)

研究领域

Biochemistry & Chemical Biology

Protein Synthesis of Mammalian Mitochondria

近期论文

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Lin, Q., Yu, N-J., and Spremulli, L. (1996) "Expression and Functional Analysis of Euglena gracilis chloroplast Initiation Factor 3" Plant Mol. Biol. 32, 937-945. Farwell, M., Schirawski, J., Hager, P., and Spremulli, L (1996) "Analysis of the Interaction between Bovine Mitochondrial 28 S Ribosomal Subunits and mRNA", Biochim. Biophys. Acta, 1309, 122-130. Woriax, V., Bullard, J., Ma, L., Yokogawa, T., and Spremulli, L. (1997) "Mechanistic Studies of the Translational Elongation Cycle in Mammalian Mitochondria" Biochim. Biophys. Acta, 1352, 91-101 Xin, H., Leanza, K., and Spremulli,L. (1997) "Expression of Bovine Mitochondrial Elongation Factor Ts in Escherichia coli and Characterization of the Heterologous Complex Formed with Prokaryotic Elongation Factor Tu" Biochim. Biophys. Acta, 1352, 102-112 Zhang, Y., Sun, V., and Spremulli, L. (1997) "Role of Domains in Escherichia coli and Mammalian Mitochondrial Elongation Factor Ts in the Interaction with Elongation Factor Tu", J. Biol. Chem. 272, 21956-21963 Yu, N-J., and Spremulli, L. (1997) "Structural and Mechanistic Studies on Chloroplast Translational Initiation Factor 3 from Euglena gracilis", Biochemistry, 36, 14827-14835 Yu, N-J., and Spremulli, L. (1998) "Regulation of the Activity of Chloroplast Translational Initiation Factor 3 by NH2- and COOH-terminal Extensions" J. Biol. Chem., 273, 3871-3877 Zhang, Y., and Spremulli, L. (1998) "Mutational Analysis of the Roles of Residues in Escherichia coli elongation factor Ts in the interaction with elongation Factor Tu" J. Biol. Chem., 273, 4556-4562 Takeuchi, N., Kawakami, M., Omori, A., Ueda, T., Spremulli, L. and Watanabe, K. (1998) "Mammalian Mitochondrial Methionyl-tRNA Transformylase from Bovine Liver: Purification, Characterization and Gene Structure" J. Biol. Chem., 273, 15085-15090 Zhang, Y. and Spremulli, L. (1998) "Roles of residues in Mammalian Mitochondrial Elongation Factor Ts in the Interaction with Mitochondrial and Bacterial Elongation Factor Tu" J. Biol. Chem., 273, 28142-28148 Zhang, Y. and Spremulli, L. (1998) "Identification and cloning of human mitochondrial translational release factor 1 and the ribosomal recycling factor" Biochim. Biophys. Acta, 1443, 245-250 Bullard, J., Cai, Y.-C., and Spremulli, L. (1999) Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. J. Mol. Biol. 288, 567-577. Bullard, J., Cai, Y.-C., Zhang, Y., & Spremulli, L. (1999) Effects of domain exchanges between Escherichia coli and mammalian mitochondrial EF-Tu on interactions with guanine nucleotides, aminoacyl-tRNA and ribosomes. Biochim Biophys Acta 1446, 102-114. Koc, E., Blackburn, K., Burkhart, W., and Spremulli, L. (1999) Identification of a mammalian mitochondrial homolog of ribosomal protein S7. Biochem. Biophys. Res. Comm., 266, 141-146 Bullard, J., Cai, Y-C.,and Spremulli, L. (2000) Expression and characterization of the human mitochondrial leucyl-tRNA synthetase. Biochim. Biophys. Acta, 1490, 245-258 Andersen, G., Thirup, S., Spremulli, L., and Nyborg, J. (2000). High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP. J. Mol. Biol. 297, 421-436 Cai, Y-C., Bullard, J. M., Thompson, N. L. and Spremulli, L. L. (2000) Interaction of mitochondrial Elongation Factor Tu with aminoacyl-tRNA and Elongation Factor Ts. J. Biol. Chem. 275, 20308-20314 Cai Y-C., Bullard, J. M., Thompson, N.L. and Spremulli, L. L. (2000) Interaction of mammalian mitochondrial Elongation Factor EF-Tu with guanine nucleotides. Prot Sci. 9, 1791-1800 Koc, E. C., Burkhart, W., Blackburn, K., Moseley, A., Koc, H., and Spremulli, L. L. (2000) "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins", J. Biol. Chem. 275, 32585-32591 Liu, M. and Spremulli, L.L. (2000) "Interaction of mammalian mitochondrial ribosomes with the inner membrane" J. Biol. Chem. 275, 29400-29406 Spremulli, L. L. (2000) Protein Synthesis, Assembly and Degradation Chapter 9 in Biochemistry and Molecular Biology of Plants (Buchanan, B. B., Gruissem, W., and Jones, R. L., eds.) American Society of Plant Physiologists, Rockville, MD. Yokogawa, T., Shimada, N., Takeuchi, N., Benkowski, L., Suzuki, T., Omori, A., Ueda, T., Nishikawa, K., Spremulli, L. L., and Watanabe, K. (2000) "Characterization and tRNA Recognition of Mammalian Mitochondrial Seryl-tRNA Synthetase" J. Biol. Chem. 275, 19913-19920. Koc E. C., Burkhart, W., Blackburn, K. Koc, H., Moseley, A., and Spremulli, L.L. (2001) "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach" Protein Science, 10, 471-481. Koc E. C., Ranasinghe, A., Burkhart, W., Blackburn, K. Koc, H., Moseley, A., and Spremulli, L.L. "A new face on apoptosis: Death associated protein 3 and PDCD9 are mitochondrial ribosomal proteins" FEBS Lett. 492, 166-170. Koc, E.C., Burkhart, W., Blackburn K., Moseley A., and Spremulli, L. L. (2001) "The small subunit of the mammalian mitochondrial ribosome: Identification of the full complement of ribosomal proteins present" J. Biol. Chem. 276, 19363-19374. He, H., Chen, M., Scheffler, N. K., Gibson, B. W., Spremulli, L. L., and Gottlieb, R. A. (2001) "Phosphorylation of Mitochondrial Elongation Factor Tu in Ischemic Myocardium: Basis for Chloramphenicol-mediated Cardioprotection" Cir. Res. 89 461-467. Koc, E.C., Burkhart, W., Blackburn K., Moyer, M. B., Schlatzer, D. M., Moseley, A., and Spremulli, L.L. (2001) "The large subunit of the mammalian mitochondrial ribosome: Analysis of the complement of ribosomal proteins present" J. Biol. Chem. 276, 43958-43969. Koc, E.C. and Spremulli, L.L. (2002) "Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs" J. Biol. Chem. 277, 35541-35549. Karring, H., Andersen, G. R., Thirup, S. S., Nyborg, J., Spremulli, L. L., Clark, B. F. C., (2002) "Isolation, crystallization, and preliminary X-ray analysis of the bovine mitochondrial EFTu: GDP and EF-Tu:EF-Ts complexes", Biochimica et Biophysica Acta - Proteins & Proteomics, 1601, 172-177. Koc, E.C. and Spremulli, L.L. (2003) "RNA-binding proteins of mammalian mitochondria" Mitochondrion 2, 277-291.