个人简介

Visiting Professor, SGC, Nuffield Department of Medicine; and Visiting Fellow, Magdalen College; Oxford University, 2013-2014. University of Washington, Seattle; Postdoctoral Fellow, 1995-1999. University of California, Los Angeles; Ph.D., 1995. University of California, Davis; B.S., 1990

研究领域

Biochemistry & Chemical Biology

Understanding Human Disease using Structural and Chemical Biology

近期论文

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Orans, J., Johnson, M.D.L., Coggan, K.A., Sperlazza, J.R., Heiniger, R.W., Wolfgang, M.C., and Redinbo, M.R. (2009). Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences USA, 107, 1065-1070. Ortlund, E.A., Bridgham, J.T., Redinbo, M.R., and Thornton, J.W. (2007). Crystal structure of an ancient protein: evolution by conformational epistasis. Science, 317, 1544-1548. Lujan, S.A., Guogas, L.M., Ragonese, H., Matson, S.W., and Redinbo, M.R. (2007). Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proceedings of the National Academy of Sciences USA, 104, 12282-12287. Ortlund, E.A., Lee, Y., Solomon, I.H., Hager, J.M., Safi, R., Choi, Y., Guan, Z., Tripathy, A., Raetz, C.R.H., McDonnell, D.P., Moore, D.D., and Redinbo, M.R. (2005). Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural and Molecular Biology, 12, 357-363. Bencharit, S., Morton, C.L., Xue, Y., Potter, P.M. and Redinbo, M.R. (2003). Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nature Structural Biology, 10, 349-356. Lesher, D.-T.T., Pommier, Y., Stewart, L., and Redinbo, M.R. (2002). 8-oxoguanine rearranges the active site of human topoisomerase I. Proceedings of the National Academy of Sciences USA, 99, 12102-12107. Bencharit, S., Morton, C.L., Howard-Williams, E.L., Danks, M.K., Potter, P.M., and Redinbo, M.R. (2002). Structural insights into CPT-11 activation by mammalian carboxylesterases. Nature Structural Biology, 9, 337-342. Watkins, R.E., Wisely, G.B., Moore, L.B., Collins, J.L., Lambert, M.H., Williams, S.P., Willson, T.M., Kliewer, S.A., and Redinbo, M.R. (2001). The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science, 292, 2329-2333. Stewart, L., Redinbo, M.R., Qiu, X., Hol, W.G.J., and Champoux, J.J. (1998). A model for the mechanism of human topoisomerase I. Science, 279, 1534-1541. Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., and Hol, W.G.J. (1998). Crystal structures of human topoisomerase I in covalent and non-covalent complexes with DNA. Science, 279, 1504-1513.