个人简介

Beijing University, B.S. , 2004; The University of Illinois at Urbana-Champaign, Ph.D., 2009; Jane Coffin Child Memorial Fund Postdoctoral Fellow, Harvard Medical School, 2009-2013

研究领域

Biochemistry & Chemical Biology

Chemical Biology, Natural Product Biosynthesis and Discovery, Antibiotic Mechanism of Action, Metabolomics, Synthetic Biology

近期论文

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Dunn, Z. D., Weaver, W. J., Economou, N. J., Bowers, A. A., Li, B. "Enzymatic Basis of 'hybridity' in Thiomarinol Biosynthesis," Angew. Chem. Int. Ed. in press. Li, B., Weaver, W. J., Walsh, C. T., Bowers, A. A. "Dithiolopyrrolones: Biosynthesis, Synthesis, and Activity of a Unique Class of Disulfide-Containing Antibiotics," Nat. Prod. Rep. 31, 905-23 (2014) (Invited review) Li, B.*, Forseth R.R.*, Bowers A.A., Schroeder F.C., Walsh, C.T. "A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus." ChemBioChem, 13, 2521-6 (2012). Highlighted in Chem. Eur. J., 18, 15904 (2012). Li, B., Walsh, C.T. "Streptomyces clavuligerus HlmI is an intramolecular disulfide-forming dithiol oxidase in holomycin biosynthesis." Biochemistry, 50, 4615-22 (2011). Li, B., Walsh, C.T. "Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus," Proc. Natl. Acad. Sci. U.S.A., 107, 19731-5 (2010). Li, B.*, Sher, D.*, Kelly, L., Shi, Y., Huang, K., Knerr, P.J., Joewono, I., Rusch, D. Chisholm, S.W., van der Donk, W.A. "Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria," Proc. Natl. Acad. Sci. U.S.A., 107, 10430-5 (2010). Highlighted in "A Most Versatile Enzyme," Chemical and Engineering News, 88, 56 (2010). Also listed as the 5th most-read paper online at Proc. Natl. Acad. Sci. U.S.A. in June, 2010 Goto, Y., Li, B., Claesen, J., Shi, Y., Bibb, M.J., van der Donk, W.A. "Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights," PLoS Biol., 8, e1000339 (2010). Cooper, L.E., Li, B., van der Donk, W.A. "Biosynthesis and mode of action of lantibiotics," In Comprehensive Natural Products Chemistry II, Eds. Mander, L., Liu, H-w., (May 2010). (Book Chapter) Li, B., Cooper, L.E., van der Donk, W.A. "Chapter 21. In vitro studies of lantibiotic biosynthesis," Methods Enzymol., 458, 533-58 (2009). (Invited Review) Li, B., van der Donk, W.A. "Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin," J. Biol. Chem., 282, 21169-75 (2007). Li, B.*, Yu, J.P.*, Brunzelle, J.S., Moll, G.N., van der Donk, W.A., Nair, S.K. "Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis," Science, 311, 1464-7 (2006). Highlighted in perspective "Five golden rings," Science, 311, 1382-3 (2006); "Antimicrobials: A ringing success," Nature Reviews Microbiol., 4, 322-3 (2006); "Resisting the resistance," ACS Chem. Biol., 1, 119 (2006); "Nisin engineered in test tube," Chemical and Engineering News, 84, 9 (2006).