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Zhang Ying, Wang Tao, Zhang Xiaojun, Deuther-Conrad Winnie, Fu Hualong, Cui Mengchao, Zhang Jinming*, Brust Peter, Huang Yiyun*, Jia Hongmei*. Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors. Acta Pharmaceutica Sinica B, 2022, 12(3): 1406-1415.
Wang Tao, Zhang Ying, Zhang Xiaojun, Chen Leyuan, Zheng Ming-Qiang, Zhang Jinming*, Brust Peter, Deuther-Conrad Winnie, Huang Yiyun*, Jia Hongmei*. Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP. Chinese Chemical Letters, 2022, 33(7): 3543-3548.
Jia Hongmei*, Cai Zhengxin, Holden Daniel, He Yingfang, Lin Shu-fei, Li Songye, Baum Evan, Shirali Anupama, Kapinos Michael, Gao Hong, Ropchan Jim, Huang Yiyun*. Positron emission tomography imaging evaluation of a novel 18F-labeled sigma-1 receptor radioligand in cynomolgus monkeys. ACS Chemical Neuroscience, 2020, 11: 1673?1681.
Tian Jiale, He Yingfang, Deuther-Conrad Winnie, Fu Hualong, Xie Fang, Zhang Ying, Wang Tao, Zhang Xiaojun, Zhang Jinming*, Brust Peter, HuangYiyun, Jia Hongmei*. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry, 2020, 28: 115560.
He Yingfang, Xie Fang, Ye Jiajun, Deuther-Conrad Winnie, Cui Bixiao, Wang Liang, Lu Jie, Steinbach J?rg, Brust Peter, Huang Yiyun, Lu Jie*, Jia Hongmei*. 1-(4-[18F]Fluorobenzyl)-4-((tetrahydrofuran-2-yl) methyl)piperazine: A novel suitable radioligand with low lipophilicity for imaging σ1 receptors in the brain. Journal of Medicinal Chemistry, 2017, 60: 4161-4172.
Wang Liang, Ye Jiajun, He Yingfang, Deuther-Conrad Winnie, Zhang Jinming, Zhang Xiaojun, Cui Mengchao*, Steinbach J?rg, Huang Yiyun, Brust Peter, Jia Hongmei*. 18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain. Bioorganic & Medicinal Chemistry, 2017, 25: 3792–3802.
Li Dan, Chen Yuanyuan, Wang Xia, Deuther-Conrad Winnie, Chen Xin, Jia Bing, Dong Chengyan, Steinbach J?rg, Brust Peter, Liu Boli, Jia Hongmei*. 99mTc-cyclopentadienyl tricarbonyl chelate-labeled compounds as selective sigma-2 receptor ligands for tumor imaging. Journal of Medicinal Chemistry, 2016, 59: 934-946.
Xie Fang, Bergmann Ralf, Kniess Torsten, Deuther-Conrad Winnie, Mamat Constantin, Neuber Christin, Liu Boli, Steinbach J?rg, Brust Peter, Pietzsch Jens, Jia Hongmei*.18F-labeled 1,4-dioxa-8-azaspiro[4.5]decane derivative: synthesis and biological evaluation of a ?1 receptor radioligand with low lipophilicity as potent tumor imaging agent. Journal of Medicinal Chemistry, 2015, 58, 5395-5407.
Xie Fang, Kniess Torsten, Neuber Christin, Deuther-Conrad Winnie, Mamat Constantin, Lieberman Brian P., Liu Boli, Mach Robert H., Brust Peter, Steinbach J?rg, Pietzsch Jens, Jia Hongmei*. Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity. MedChemComm, 2015, 6, 1093-1103.
Wang Xia, Li Dan, Deuther-Conrad Winnie, Lu Jie, Xie Ying, Jia Bing, Cui Mengchao, Steinbach J?rg, Brust Peter, Liu Boli, Jia Hongmei*. Novel cyclopentadienyl tricarbonyl 99mTc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. Journal of Medicinal Chemistry, 2014, 57, 7113-7125.
Chen Yuan-Yuan, Wang Xia, Zhang Jin-Ming, Deuther-Conrad Winnie, Zhang Xiao-Jun, Huang Yiyun, Li Yan, Ye Jia-Jun, Cui Meng-Chao, Steinbach Joerg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising ?1 receptor imaging agent. Bioorganic & Medicinal Chemistry, 2014, 22: 5270–5278.
Li Yan, Wang Xia, Zhang Jinming, Deuther-Conrad Winniw, Xie Fang, Zhang Xiaojun, Liu Jian, Qiao Jinping, Cui Mengchao, Steinbach Joerg, Brust Peter, Liu Boli, Jia Hongmei*. Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging. Journal of Medicinal Chemistry, 2013, 56, 3478-3491.
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